The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Regenerative Medicine in Orthopaedic Surgery: Pioneering Advances and Their Applications
Open accessAbstract
Regenerative medicine has significantly impacted orthopaedic surgery by introducing biological therapies aimed at repairing, restoring, or replacing damaged musculoskeletal tissues. Recent advancements in stem cell therapies, platelet-rich plasma (PRP), and tissue engineering have paved the way for improved treatments for cartilage, bone, tendon, and ligament injuries. Mesenchymal stem cells (MSC) and induced pluripotent stem cells (iPSC) are gaining attention for their ability to regenerate tissues, while PRP shows promise in accelerating tendon and cartilage healing. Innovations in cartilage regeneration, including autologous chondrocyte implantation and biomimetic scaffolds, address the limitations of self-repair, and bone regeneration is being enhanced through growth factors like bone morphogenetic proteins (BMP) and synthetic grafts. In tendon and ligament repair, biological augmentation with scaffolds and growth factors is emerging as a novel approach. Moreover, regenerative approaches are making strides in spinal surgery and joint preservation, particularly in osteoarthritis treatment. However, challenges such as regulatory hurdles, cost, and the need for further clinical evidence remain. As the field progresses, the integration of cutting-edge techniques like 3D printing and gene therapy could further revolutionise orthopaedic regenerative medicine.
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As a result, regenerative therapies have gained considerable attention in recent years for their potential to accelerate healing, restore function, and, in some cases, provide alternative solutions to surgery [2].”
In the citing paper
“PRP and MSC therapies are among the most studied regenerative treatments for musculoskeletal injuries, while peptide-based interventions and biomimetic materials represent newer, promising strategies aimed at enhancing infection control, tissue integration, and functional recovery [2,6].”
In the citing paper
“Despite the increasing number of studies on regenerative medicine in orthopedics, the field remains fragmented, with inconsistent findings across trials and a lack of standardization in therapy preparation and clinical application [2].”
In the citing paper
“While previous reviews have explored individual regenerative therapies in orthopedics, few provide a comparative analysis across multiple regenerative strategies [2,6].”
In the citing paper
“PRP and MSC therapies are among the most studied regenerative treatments for musculoskeletal injuries, while peptide-based interventions and biomimetic materials represent newer, promising strategies aimed at enhancing infection control, tissue integration, and functional recovery [2,6].”
Citations
Cites
Mithoefer, K., McAdams, T., Williams, R. J., Kreuz, P. C., & Mandelbaum, B. R. (2009) · The American Journal of Sports Medicine · doi:10.1177/0363546508328414 · Cited by 1,013
Autologous Chondrocyte Implantation: A Systematic Review
Harris, J. D., Siston, R. A., Pan, X., & Flanigan, D. C. (2010) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/jbjs.j.00049 · Cited by 409
Platelet Rich Plasma: a short overview of certain bioactive components
Pavlovic, V., Ciric, M., Jovanovic, V., & Stojanovic, P. (2016) · Open Medicine · doi:10.1515/med-2016-0048 · Cited by 405
Articular cartilage: from formation to tissue engineering
Camarero-Espinosa, S., Rothen-Rutishauser, B., Foster, E. J., & Weder, C. (2016) · Biomaterials Science · doi:10.1039/c6bm00068a · Cited by 328
Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration
Albanese, A., Licata, M. E., Polizzi, B., & Campisi, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-23 · Cited by 316
Matsushita, Y., Nagata, M., Kozloff, K. M., Welch, J. D., Mizuhashi, K., Tokavanich, N., Hallett, S. A., Link, D. C., Nagasawa, T., Ono, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14029-w · Cited by 298
Platelet-Rich Plasma Releasate Promotes Differentiation of Tendon Stem Cells into Active Tenocytes
Zhang, J., & Wang, J. H.-C. (2010) · The American Journal of Sports Medicine · doi:10.1177/0363546510376750 · Cited by 256
HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons
Zhang, J., Middleton, K. K., Fu, F. H., Im, H., & Wang, J. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067303 · Cited by 218
Oudelaar, B. W., Peerbooms, J. C., Veld, R. H. I. ‘., & Vochteloo, A. J. H. (2018) · The American Journal of Sports Medicine · doi:10.1177/0363546517746112 · Cited by 212
Research works printed but not linked: 1
- Deng Y et al. 4D printed shape memory polyurethane-based composite for bionic cartilage scaffolds. ACS Appl Polym Mater. 2023;5(2):1283-92. · DOI
Cited by
Goulian, A. J., Goldstein, B., & Saad, M. A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062061 · Cited by 25
“Despite the increasing number of studies on regenerative medicine in orthopedics, the field remains fragmented, with inconsistent findings across trials and a lack of standardization in therapy preparation and clinical application [2].”
Metadata
- Authors
- Islam, M. T., Bulut, D., & Sharabidze, Z.
- Affiliations
- International Teaching University of Georgia (GE)
- National Cancer Center of Georgia (GE)
- Venue
- EMJ Innovation
- Publisher
- European Medical Group
- Published
- 2025-01-14
- ISSN
- 2513-8634 (ISSN-L)
- OpenAlex
- W4406473394
- Cited by
- 10
- References
- 93
- Citations by year
- 2026: 5 · 2025: 5
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- EMJ Innovation (publishedVersion, cc-by-nc)
- Topics
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- regenerative medicine, orthopedic surgery, stem cell therapy, platelet-rich plasma, tissue engineering, mesenchymal stem cells, induced pluripotent stem cells, cartilage regeneration, bone regeneration, tendon repair, ligament repair, autologous chondrocyte implantation, biomimetic scaffolds, bone morphogenetic proteins, osteoarthritis, spinal surgery, joint preservation, 3D printing, gene therapy
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
