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Regenerative Medicine in Orthopaedic Surgery: Pioneering Advances and Their Applications
Open accessAbstract
Regenerative medicine has significantly impacted orthopaedic surgery by introducing biological therapies aimed at repairing, restoring, or replacing damaged musculoskeletal tissues. Recent advancements in stem cell therapies, platelet-rich plasma (PRP), and tissue engineering have paved the way for improved treatments for cartilage, bone, tendon, and ligament injuries. Mesenchymal stem cells (MSC) and induced pluripotent stem cells (iPSC) are gaining attention for their ability to regenerate tissues, while PRP shows promise in accelerating tendon and cartilage healing. Innovations in cartilage regeneration, including autologous chondrocyte implantation and biomimetic scaffolds, address the limitations of self-repair, and bone regeneration is being enhanced through growth factors like bone morphogenetic proteins (BMP) and synthetic grafts. In tendon and ligament repair, biological augmentation with scaffolds and growth factors is emerging as a novel approach. Moreover, regenerative approaches are making strides in spinal surgery and joint preservation, particularly in osteoarthritis treatment. However, challenges such as regulatory hurdles, cost, and the need for further clinical evidence remain. As the field progresses, the integration of cutting-edge techniques like 3D printing and gene therapy could further revolutionise orthopaedic regenerative medicine.
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In the citing paper
“As a result, regenerative therapies have gained considerable attention in recent years for their potential to accelerate healing, restore function, and, in some cases, provide alternative solutions to surgery [2].”
In the citing paper
“PRP and MSC therapies are among the most studied regenerative treatments for musculoskeletal injuries, while peptide-based interventions and biomimetic materials represent newer, promising strategies aimed at enhancing infection control, tissue integration, and functional recovery [2,6].”
In the citing paper
“Despite the increasing number of studies on regenerative medicine in orthopedics, the field remains fragmented, with inconsistent findings across trials and a lack of standardization in therapy preparation and clinical application [2].”
In the citing paper
“While previous reviews have explored individual regenerative therapies in orthopedics, few provide a comparative analysis across multiple regenerative strategies [2,6].”
In the citing paper
“PRP and MSC therapies are among the most studied regenerative treatments for musculoskeletal injuries, while peptide-based interventions and biomimetic materials represent newer, promising strategies aimed at enhancing infection control, tissue integration, and functional recovery [2,6].”
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Cited by
Goulian, A. J., Goldstein, B., & Saad, M. A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062061 · Cited by 25
“Despite the increasing number of studies on regenerative medicine in orthopedics, the field remains fragmented, with inconsistent findings across trials and a lack of standardization in therapy preparation and clinical application [2].”
Metadata
- Authors
- Islam, M. T., Bulut, D., & Sharabidze, Z.
- Affiliations
- International Teaching University of Georgia (GE)
- National Cancer Center of Georgia (GE)
- Venue
- EMJ Innovation
- Publisher
- European Medical Group
- Published
- 2025-01-14
- ISSN
- 2513-8634 (ISSN-L)
- OpenAlex
- W4406473394
- Cited by
- 10
- References
- 93
- Citations by year
- 2026: 5 · 2025: 5
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- EMJ Innovation (publishedVersion, cc-by-nc)
- Topics
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- regenerative medicine, orthopedic surgery, stem cell therapy, platelet-rich plasma, tissue engineering, mesenchymal stem cells, induced pluripotent stem cells, cartilage regeneration, bone regeneration, tendon repair, ligament repair, autologous chondrocyte implantation, biomimetic scaffolds, bone morphogenetic proteins, osteoarthritis, spinal surgery, joint preservation, 3D printing, gene therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
