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Primary Antiphospholipid Syndrome
Abstract
An antiphospholipid antibody (APLA) syndrome has been proposed for those patients with systemic lupus erythematosus (SLE) or with other connective tissue diseases who have APLA and manifestations that seem related to their effect (venous thrombosis, arterial occlusions, thrombocytopenia, hemolytic anemia, recurrent fetal loss, leg ulcers, and livedo reticularis). Occurrence of a primary antiphospholipid syndrome has also been mentioned but not defined. We present 9 young patients who had at least 2 of the clinical manifestations that have been related to high titers of APLA, but had neither SLE nor other recognizable connective tissue disease. We propose criteria for diagnosis of such a primary antiphospholipid syndrome and discuss the possible mechanisms whereby a single autoantibody can cause systemic disease.
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Cited by
Levine, J. S., Branch, D. W., & Rauch, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra002974 · Cited by 1,543
The management of thrombosis in the antiphospholipid-antibody syndrome
Khamashta, M. A., Cuadrado, M. J., Mujic, F., Taub, N. A., Hunt, B. J., & Hughes, G. R. V. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321504 · Cited by 1,450
Immunology and clinical importance of antiphospholipid antibodies
McNeil, H. P., Chesterman, C. N., & Krilis, S. A. (1991) · Advances in immunology · doi:10.1016/s0065-2776(08)60777-4 · Cited by 481
Blank, M., Cohen, J., Toder, V, & Shoenfeld, Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3069 · Cited by 455
Prevalence, Follow-Up and Clinical Significance of the Anticardiolipin Antibodies in Normal Subjects
Vila, P., Hernández, M. C., López-Fernández, M. F., & Batlle, J. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648840 · Cited by 280
Metadata
- Venue
- Frontiers Research Topics
- Publisher
- Frontiers Media SA
- Published
- 2020
- Volume
- 16
- Issue
- 4
- Pages
- 482-8
- ISSN
- 1664-8714 (ISSN-L)
- OpenAlex
- W2413103043
- Cited by
- 346
- References
- 0
- FWCI
- 3.84
- Type
- book
- Language
- en
- Open access
- closed
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