The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Prevalence, Follow-Up and Clinical Significance of the Anticardiolipin Antibodies in Normal Subjects
Abstract
Summary: To date very few studies that analyze the prevalence of anticardiolipin antibodies (ACA) in healthy subjects have been reported. No data based on a systematic analysis of normal subjects with positive ACA is available. The aim of the present study was to evaluate the prevalance of ACA, its clinical significance and relationship to the lupus anticoagulant (LA) and other autoimmune parameters in an apparently healthy population. 552 normal blood donors from a blood bank were randomly selected. ACA positive donors who consented were monitored over a period of twelve months and tested every three months. ACA (IgG and IgM isotypes) were quantitated by enzyme linked immunoassay (ELISA). The prevalance for IgG ACA in our donor population was estimated to be 6.5%, and 9.4% for IgM ACA, which is similar to the one previously reported for IgG and slightly higher for IgM. It is worth noting that in our study ACA positive donors exhibited a progressive negativization. Eight donors with IgG ACA and seven with IgM ACA remained positive for nine months. Five donors with IgG ACA and four with IgM ACA had family history of thromboembolic disease. One donor with IgG ACA and two with IgM ACA had had unexplained miscarriages in the past. We did not find any relationship between ACA and LA, nor between ACA positivity and the clinical and laboratory data studied. Pseudopositivity for lues was not found. No thrombotic event occurred in donors that were positive for ACA during the 12-month follow-up.
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Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis
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Cited by
Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170
Sacco, R. L., Adams, R., Albers, G., Alberts, M. J., Benavente, O., Furie, K., Goldstein, L. B., Gorelick, P., Halperin, J., Harbaugh, R., et al. (2006) · Stroke · doi:10.1161/01.str.0000199147.30016.74 · Cited by 1,873
Diagnosis and management of the antiphospholipid syndrome
Garcia, D., & Erkan, D. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1705454 · Cited by 819
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
Management of Antiphospholipid Antibody Syndrome: A Systematic Review
Lim, W., Crowther, M. A., & Eikelboom, J. W. (2006) · JAMA · doi:10.1001/jama.295.9.1050 · Cited by 448
Metadata
- Authors
- Vila, P., Hernández, M. C., López-Fernández, M. F., & Batlle, J.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994
- Volume
- 72
- Issue
- 02
- Pages
- 209-213
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W61805567
- Cited by
- 280
- References
- 36
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vila, P., Hernández, M. C., López-Fernández, M. F., & Batlle, J. (1994). Prevalence, Follow-Up and Clinical Significance of the Anticardiolipin Antibodies in Normal Subjects. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0038-1648840
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