The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Link Between m6A Modification and Cancers
Open accessAbstract
N6-methyladenosine (m6A) epitranscriptional modification has recently gained much attention. Through the development of m6A sequencing, the molecular mechanism and importance of m6A have been revealed. m6A is the most abundant internal modification in higher eukaryotic mRNAs, which plays crucial roles in mRNA metabolism and multiple biological processes. In this review, we introduce the characteristics of m6A regulators, including "writers" that create m6A mark, "erasers" that show demethylation activity and "readers" that decode m6A modification to govern the fate of modified transcripts. Moreover, we highlight the roles of m6A modification in several common cancers, including solid and non-solid tumors. The regulators of m6A exert enormous functions in cancer development, such as proliferation, migration and invasion. Especially, with the underlying mechanisms being uncovered, m6A and its regulators are expected to be the targets for the diagnosis and treatment of cancers.
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Cites
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Cited by
Accurate detection of m6A RNA modifications in native RNA sequences
Liu, H., Begik, O., Lucas, M. C., Ramirez, J. M., Mason, C. E., Wiener, D., Schwartz, S., Mattick, J. S., Smith, M. A., & Novoa, E. M. (2019) · Nature Communications · doi:10.1038/s41467-019-11713-9 · Cited by 518
Chen, J., Zhang, H., Xiu, C., Gao, C., Wu, S., Bai, J., Shen, Q., & Yin, T. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216222 · Cited by 71
Liu, H., Qin, S., Liu, C., Jiang, L., Li, C., Yang, J., Zhang, S., Yan, Z., Liu, X., Yang, J., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00674-y · Cited by 58
Metadata
- Authors
- Liu, Z.-X., Li, L.-M., Sun, H.-L., & Liu, S.-M.
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2018-07-13
- Volume
- 6
- Pages
- 89-89
- ISSN
- 2296-4185 (ISSN-L)
- OpenAlex
- W2829377719
- Cited by
- 373
- References
- 74
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, Z.-X., Li, L.-M., Sun, H.-L., & Liu, S.-M. (2018). Link Between m6A Modification and Cancers. Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2018.00089
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
