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Cited by 152Tissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applicationsCongenital heart defects research

The DOI matches its Crossref record; 160 of the 164 references it cites were found in a registry or an index.

Alginate Formulations: Current Developments in the Race for Hydrogel-Based Cardiac Regeneration

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Cattelan, Giada, Guerrero Gerbolés, Amparo, Foresti, Ruben, Pramstaller, Peter P., Rossini, Alessandra, Miragoli, Michele, Caffarra Malvezzi, Cristina·2020·Frontiers in Bioengineering and Biotechnology
DOI 10.3389/fbioe.2020.00414PMC PMC7226066
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Abstract

Cardiovascular diseases, including myocardial infarction, represent the main worldwide cause of mortality and morbidity. In this scenario, to contrast the irreversible damages following myocardial infarction, cardiac regeneration has emerged as a novel and promising solution for in situ cellular regeneration, preserving cell behavior and tissue cytoarchitecture. Among the huge variety of natural, synthetic, and hybrid compounds used for tissue regeneration, alginate emerged as a good candidate for cellular preservation and delivery, becoming one of the first biomaterial tested in pre-clinical research and clinical trials concerning cardiovascular diseases. Although promising results have been obtained, recellularization and revascularization of the infarcted area present still major limitations. Therefore, the demand is rising for alginate functionalization and its combination with molecules, factors, and drugs capable to boost the regenerative potential of the cardiac tissue. The focus of this review is to elucidate the promising properties of alginate and to highlight its benefits in clinical trials both in relation to cardiac regeneration. The definition of hydrogels, the alginate characteristics, and recent biomedical applications are herewith described. Afterwards, the review examines in depth the ongoing developments to refine the material relevance in cardiac recovery and regeneration after myocardial infarction (MI) and presents current clinical trials based on alginate.

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Metadata

Authors
Cattelan, G., Guerrero Gerbolés, A., Foresti, R., Pramstaller, P. P., Rossini, A., Miragoli, M., & Caffarra Malvezzi, C.
Affiliations
  • Eurac Research (IT)
  • University of Parma (IT)
Corresponding author
Cattelan, Giada
ORCID
Venue
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Published
2020-05-08
Volume
8
Pages
414-414
ISSN
2296-4185 (ISSN-L)
DOI
10.3389/fbioe.2020.00414
PMC
PMC7226066
OpenAlex
W3030898095
Cited by
152
References
164
Citations by year
2026: 12 · 2025: 22 · 2024: 37 · 2023: 35 · 2022: 16 · 2021: 26 · 2020: 4
FWCI
4.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Open Research (University of Surrey) (submittedVersion, other-oa)
Funders
  • Università degli Studi di Parma
  • Provincia autonoma di Bolzano - Alto Adige
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
alginate hydrogel, cardiac regeneration, myocardial infarction, cell delivery, cell preservation, recellularization, revascularization, biomaterials, clinical trials, tissue engineering

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