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Alginate Formulations: Current Developments in the Race for Hydrogel-Based Cardiac Regeneration
Open accessAbstract
Cardiovascular diseases, including myocardial infarction, represent the main worldwide cause of mortality and morbidity. In this scenario, to contrast the irreversible damages following myocardial infarction, cardiac regeneration has emerged as a novel and promising solution for in situ cellular regeneration, preserving cell behavior and tissue cytoarchitecture. Among the huge variety of natural, synthetic, and hybrid compounds used for tissue regeneration, alginate emerged as a good candidate for cellular preservation and delivery, becoming one of the first biomaterial tested in pre-clinical research and clinical trials concerning cardiovascular diseases. Although promising results have been obtained, recellularization and revascularization of the infarcted area present still major limitations. Therefore, the demand is rising for alginate functionalization and its combination with molecules, factors, and drugs capable to boost the regenerative potential of the cardiac tissue. The focus of this review is to elucidate the promising properties of alginate and to highlight its benefits in clinical trials both in relation to cardiac regeneration. The definition of hydrogels, the alginate characteristics, and recent biomedical applications are herewith described. Afterwards, the review examines in depth the ongoing developments to refine the material relevance in cardiac recovery and regeneration after myocardial infarction (MI) and presents current clinical trials based on alginate.
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“Alginate has a number of advantages that make it attractive as a material for further study; it is inexpensive, relatively easy to modify and functionalize, biocompatible, and has been used in a wide range of biological and materials applications106–108.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [108]
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Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409
Bojorges, H., López‐Rubio, A., Martínez‐Abad, A., & Fabra, M. J. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104142 · Cited by 247
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Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications
Elkhoury, K., Morsink, M. A. J., Sánchez‐González, L., Kahn, C. J. F., Tamayol, A., & Arab‐Tehrany, E. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.040 · Cited by 162
Metadata
- Authors
- Cattelan, G., Guerrero Gerbolés, A., Foresti, R., Pramstaller, P. P., Rossini, A., Miragoli, M., & Caffarra Malvezzi, C.
- Affiliations
- Eurac Research (IT)
- University of Parma (IT)
- Corresponding author
- Cattelan, Giada
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2020-05-08
- Volume
- 8
- Pages
- 414-414
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC7226066
- OpenAlex
- W3030898095
- Cited by
- 152
- References
- 164
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 37 · 2023: 35 · 2022: 16 · 2021: 26 · 2020: 4
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Open Research (University of Surrey) (submittedVersion, other-oa)
- Funders
- Università degli Studi di Parma
- Provincia autonoma di Bolzano - Alto Adige
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- alginate hydrogel, cardiac regeneration, myocardial infarction, cell delivery, cell preservation, recellularization, revascularization, biomaterials, clinical trials, tissue engineering
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