Polydopamine surface-modified hyperbranched polymeric nanoparticles for synergistic chemo/photothermal therapy of oral cancer
Open accessAbstract
A novel drug delivery system for the treatment of oral cancer was developed using a facile polydopamine (PDA)-based surface modification and a binding mechanism linking folic acid-targeting ligands. The system was able to achieve the following objectives: loading of chemotherapeutic agents, active targeting, pH responsiveness, and prolonged in vivo blood circulation. DOX-loaded polymeric nanoparticles (DOX/H20-PLA@PDA NPs) were functionalized with amino-poly (ethylene glycol)-folic acid (H 2 N-PEG-FA) after coating them with PDA to form the targeting combination, DOX/H20-PLA@PDA-PEG-FA NPs. The novel NPs exhibited drug delivery characteristics similar to DOX/H20-PLA@ PDA NPs. Meanwhile, the incorporated H 2 N-PEG-FA contributed to active targeting, as illustrated in cellular uptake assays and animal studies. In vitro cytotoxicity and in vivo anti-tumor studies have shown that the novel nanoplatforms exhibit extremely effective therapeutic effects. In conclusion, the multifunctional PDA-modified H20-PLA@PDA-PEG-FA NPs offer a promising chemotherapeutic strategy to improve the treatment of oral cancer.
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Anti-inflammatory agents such as dexamethasone are encapsulated within PDA nanocapsules and conjugated through pH-sensitive linkages, including hydrazone bonds.
“In a representative strategy, anti-inflammatory agents, such as dexamethasone, are encapsulated within PDA nanocapsules and conjugated through pH-sensitive linkages, including hydrazone bonds.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [77]
The Results and discussion sections on nanoparticle synthesis and characterization describe loading the anticancer drug doxorubicin into polymeric nanoparticles coated with PDA, not encapsulating dexamethasone in PDA nanocapsules. They attribute pH-responsive release to possible shedding of the PDA film in acid and identify Michael addition for ligand attachment, not hydrazone linkages. (LLM, conf=0.88)
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Experimental — accuracy not yet measuredPDA-based nanocarriers with pH-responsive drug release behavior have been extensively developed.
“pH-responsive release: PDA-based nanocarriers with pH-responsive drug release behavior have been extensively developed, as shown in Figure 6.76,77”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [77]
The Results and discussion (Characterization of polymeric NPs; page unavailable) report pH-responsive drug release from the paper’s PDA-modified nanocarrier. The Introduction and References mention other PDA drug carriers, including pH-sensitive examples, but the paper does not establish the stronger claim that such carriers have been extensively developed. (LLM, conf=0.82)
Experimental — accuracy not yet measuredFor oral tumor therapy, PDA-mediated photothermal or chemo-photothermal strategies remain mostly at the proof-of-concept stage.
“For oral tumor therapy, PDA-mediated photothermal or chemo-photothermal strategies remain mostly at the proof-of-concept stage.77”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [77]
The Introduction (page unavailable) says no nanoplatforms are approved for clinical treatment of oral cancer, and the Methods describe testing this PDA-based chemo-photothermal treatment in mice. That supports its preclinical status, but the paper does not establish that PDA-mediated oral-tumor strategies as a whole are mostly at the proof-of-concept stage. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show that PDA-based systems can achieve biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.
“In vitro antibacterial assays, simplified biofilm models, release studies, and selected animal models show biofilm inhibition, ROS regulation, localized drug release, photothermal/photodynamic antibacterial effects, and inflammation control.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [77]
The Results and discussion (Characterization of polymeric NPs; page unavailable) report pH- and laser-responsive doxorubicin release and photothermal conversion. The In Vivo anti-tumor efficacy section describes a mouse tumor model, not an antibacterial model. The paper does not report biofilm inhibition, ROS regulation, photodynamic antibacterial effects, or inflammation control. (LLM, conf=0.88)
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Self-citation
- Authors
- Yin, X., Li, Z., Zhang, Y., Zeng, X., Wang, Q., & Liang, Z.
- Affiliations
- Shenzhen Second People's Hospital (CN)
- Sun Yat-sen University (CN)
- Corresponding author
- Zeng, Xiaowei
- Wang, Qiuxu
- Liang, Zhigang
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2023-05-05
- Volume
- 11
- Pages
- 1174014-1174014
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC10197810
- OpenAlex
- W4377563946
- Cited by
- 15
- References
- 53
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20210324102810028)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polydopamine surface modification, oral cancer, photothermal therapy, chemotherapy, doxorubicin, folic acid targeting, pH-responsive nanoparticles, drug delivery systems, active targeting, blood circulation, tumor targeting
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