Reprogramming cell fate: a changing story

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Expression of a single transfected cDNA converts fibroblasts to myoblasts

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Direct conversion of fibroblasts to functional neurons by defined factors

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Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

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Epigenetic memory in induced pluripotent stem cells

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Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

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In vivo reprogramming of adult pancreatic exocrine cells to β-cells

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Sheep cloned by nuclear transfer from a cultured cell line

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Chemically defined generation of human cardiomyocytes

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Pioneer transcription factors: establishing competence for gene expression

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miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

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In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

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Induction of human neuronal cells by defined transcription factors

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Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

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The promise of induced pluripotent stem cells in research and therapy

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Heart repair by reprogramming non-myocytes with cardiac transcription factors

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Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

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Stepwise reprogramming of B cells into macrophages.

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Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

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Direct cell reprogramming is a stochastic process amenable to acceleration

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Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.

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MicroRNA-mediated conversion of human fibroblasts to neurons

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Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., & Hui, L. (2011) · Nature · doi:10.1038/nature10116 · Cited by 864 · see citing works

Cytoplasmic activation of human nuclear genes in stable heterocaryons

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Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

Sekiya, S., & Suzuki, A. (2011) · Nature · doi:10.1038/nature10263 · Cited by 846 · see citing works

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

Guo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., & Chen, G. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.12.001 · Cited by 830 · see citing works

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

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Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

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Direct conversion of human fibroblasts to dopaminergic neurons

Pfisterer, U., Kirkeby, A., Torper, O., Wood, J. C., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J., & Parmar, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105135108 · Cited by 740 · see citing works

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators

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Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

Hanna, J. H., Saha, K., & Jaenisch, R. (2010) · Cell · doi:10.1016/j.cell.2010.10.008 · Cited by 695 · see citing works

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

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Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

Efe, J. A., Hilcove, S. A., Kim, J., Zhou, H., Ouyang, K., Wang, G., Chen, J., & Ding, S. (2011) · Nature Cell Biology · doi:10.1038/ncb2164 · Cited by 618 · see citing works

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

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Sexually Mature Individuals of Xenopus laevis from the Transplantation of Single Somatic Nuclei

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Reprogramming of human fibroblasts toward a cardiac fate

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Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

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Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

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PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

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Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

Lujan, E., Chanda, S., Ahlenius, H., Südhof, T. C., & Wernig, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121003109 · Cited by 421 · see citing works

GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts.

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Generation of induced neurons via direct conversion in vivo

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Silencing chromatin: comparing modes and mechanisms

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Transfection of a DNA locus that mediates the conversion of 10T12 fibroblasts to myoblasts

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Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

Fu, J., Stone, N. R., Liu, L., Spencer, C. I., Li, Q., Hayashi, Y., Delgado-Olguı́n, P., Ding, S., Bruneau, B. G., & Srivastava, D. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.07.005 · Cited by 370 · see citing works

PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells

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Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

Marro, S. G., Pang, Z. P., Yang, N., Tsai, M.-C., Qu, K., Chang, H. Y., Südhof, T. C., & Wernig, M. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.09.002 · Cited by 343 · see citing works

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

Liu, M.-L., Zang, T., Zou, Y., Chang, J. C., Gibson, J. R., Huber, K. M., & Zhang, C.-L. (2013) · Nature Communications · doi:10.1038/ncomms3183 · Cited by 343 · see citing works

Induction of human cardiomyocyte-like cells from fibroblasts by defined factors

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MiR‐133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures

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Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5

Inagawa, K., Miyamoto, K., Yamakawa, H., Muraoka, N., Sadahiro, T., Umei, T. C., Wada, R., Katsumata, Y., Kaneda, R., Nakade, K., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.271148 · Cited by 260 · see citing works

Efficient Direct Reprogramming of Mature Amniotic Cells into Endothelial Cells by ETS Factors and TGFβ Suppression

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Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

Chen, J., Krane, M., Deutsch, M.-A., Wang, L., Rav-Acha, M., Grégoire, S., Engels, M. C., Rajarajan, K., Karra, R., Abel, E. D., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.270264 · Cited by 228 · see citing works

Mediators of reprogramming: transcription factors and transitions through mitosis

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Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success

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Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors

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A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells

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GATA‐1 but not SCL induces megakaryocytic differentiation in an early myeloid line.

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Molecular Roadblocks for Cellular Reprogramming

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Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming

Taberlay, P. C., Kelly, T. K., Liu, C.-C., You, J. S., Carvalho, D. D. D., Miranda, T. B., Zhou, X. J., Liang, G., & Jones, P. A. (2011) · Cell · doi:10.1016/j.cell.2011.10.040 · Cited by 172 · see citing works

Inhibition of TGFβ Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes

Ifkovits, J. L., Addis, R. C., Epstein, J. A., & Gearhart, J. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089678 · Cited by 168 · see citing works

Transcription Factors MYOCD, SRF, Mesp1 and SMARCD3 Enhance the Cardio-Inducing Effect of GATA4, TBX5, and MEF2C during Direct Cellular Reprogramming

Christoforou, N., Chellappan, M. K., Adler, A. F., Kirkton, R., Wu, T.-Y., Addis, R., Bursac, N., & Leong, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063577 · Cited by 153 · see citing works

Transcription factor‐mediated lineage switching reveals plasticity in primary committed progenitor cells

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Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

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Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer

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A blueprint for engineering cell fate: current technologies to reprogram cell identity

Morris, S. A., & Daley, G. Q. (2013) · Cell Research · doi:10.1038/cr.2013.1 · Cited by 129 · see citing works

Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells

Zhu, S., Ambasudhan, R., Sun, W., Kim, H. J., Talantova, M. V., Wang, X., Zhang, M., Zhang, Y., Laurent, T., Parker, J., et al. (2013) · Cell Research · doi:10.1038/cr.2013.156 · Cited by 114 · see citing works

Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain

Hirai, H., Katoku-Kikyo, N., Keirstead, S. A., & Kikyo, N. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt167 · Cited by 93 · see citing works

Smooth Muscle Cells Differentiated From Reprogrammed Embryonic Lung Fibroblasts Through DKK3 Signaling Are Potent for Tissue Engineering of Vascular Grafts

Karamariti, E., Margariti, A., Winkler, B. M., Wang, X., Hong, X., Baban, D. F., Ragoussis, J., Huang, Y. C., Han, J. J., Wong, M. M., et al. (2013) · Circulation Research · doi:10.1161/circresaha.111.300415 · Cited by 91 · see citing works

Induced regeneration—the progress and promise of direct reprogramming for heart repair

Addis, R. C., & Epstein, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3225 · Cited by 88 · see citing works

Activation of Neural Cell Fate Programs Toward Direct Conversion of Adult Human Fibroblasts into Tri-Potent Neural Progenitors Using OCT-4

Mitchell, R. R., Szabo, E., Benoit, Y. D., Case, D. T., Mechael, R., Alamilla, J., Lee, J., Fiebig‐Comyn, A., Gillespie, D. C., & Bhatia, M. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0023 · Cited by 68 · see citing works

Inhibitors of suppressive histone modification promote direct reprogramming of fibroblasts to cardiomyocyte-like cells

Hirai, H., & Kikyo, N. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu023 · Cited by 54 · see citing works

Molecular Evidence for OCT4-Induced Plasticity in Adult Human Fibroblasts Required for Direct Cell Fate Conversion to Lineage Specific Progenitors

Mitchell, R. R., Szabo, E., Shapovalova, Z., Aslostovar, L., Makondo, K. J., & Bhatia, M. (2014) · Stem Cells · doi:10.1002/stem.1721 · Cited by 45 · see citing works

Direct Conversion of Fibroblasts to Functional Neurons

Yashar, M., Kalani, S., & Martirosyan, N. L. (2011) · World Neurosurgery · doi:10.1016/j.wneu.2011.11.002 · Cited by 20 · see citing works

Toward directed reprogramming through exogenous factors

Lin, C., Chen, Y., & Ding, S. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.06.002 · Cited by 14 · see citing works

Pancreatic Islet Cells

Kinzer, K., Salmon, P., & Oberholzer, J. (2012) · doi:10.1002/9781118498453.ch18 · Cited by 14 · see citing works

Ascorbic acid rescues cardiomyocyte development in Fgfr1−/− murine embryonic stem cells

Crescini, E., Gualandi, L., Uberti, D. L., Prandelli, C., Presta, M., & Dell’Era, P. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.06.024 · Cited by 12 · see citing works

Small Molecules Convert Fibroblasts into Islet-like Cells Avoiding Pluripotent State

Lumelsky, N. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.019 · Cited by 5 · see citing works

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

Jolly, M. K. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00155 · Cited by 684 · see citing works

Diverse reprogramming codes for neuronal identity

Tsunemoto, R. K., Lee, S., Szűcs, A. L., Chubukov, P., Sokolova, I., Blanchard, J., Eade, K., Bruggemann, J., Wu, C., Torkamani, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0103-5 · Cited by 122 · see citing works

PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes

Sasamoto, Y., Hayashi, R., Park, S., Saito-Adachi, M., Suzuki, Y., Kawasaki, S., Quantock, A. J., Nakai, K., Tsujikawa, M., & Nishida, K. (2016) · Scientific Reports · doi:10.1038/srep20807 · Cited by 55 · see citing works

Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin

Sun, X., Xiang, J., Chen, R., Geng, Z., Wang, L., Liu, Y., Ji, S., Chen, H., Li, Y., Zhang, C., et al. (2021) · Advanced Science · doi:10.1002/advs.202103079 · Cited by 42 · see citing works

Cellular reprogramming for clinical cartilage repair

Driessen, B. J. H., Logie, C., & Vonk, L. A. (2017) · Cell Biology and Toxicology · doi:10.1007/s10565-017-9382-0 · Cited by 37 · see citing works

Cell-Fate Specification in Arabidopsis Roots Requires Coordinative Action of Lineage Instruction and Positional Reprogramming

Yu, Q., Li, P., Liang, N., Hong, W., Xu, M., & Wu, S. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.00814 · Cited by 32 · see citing works

Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications

Jiang, M., Ren, J., Belmonte, J. C. I., & Liu, G. (2023) · FEBS Journal · doi:10.1111/febs.16930 · Cited by 20 · see citing works

Direct Conversion Through Trans-Differentiation: Efficacy and Safety

Prasad, A., Teh, D. B. L., Jahan, F. R. S., Manivannan, J., Chua, S. M., & All, A. H. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0174 · Cited by 21 · see citing works

Engineering cell fate: Spotlight on cell-activation and signaling-directed lineage conversion

Ebrahimi, B. (2016) · Tissue and Cell · doi:10.1016/j.tice.2016.07.005 · Cited by 10 · see citing works

Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain

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Cell and tissue reprogramming: Unlocking a new era in medical drug discovery

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