The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
Open accessAbstract
The MAP kinase signaling cascade Ras/Raf/MEK/ERK has been involved in a large variety of cellular and physiological processes that are crucial for life. Many pathological situations have been associated to this pathway. More than one isoform has been described at each level of the cascade. In this review we devoted our attention to ERK1 and ERK2, which are the effector kinases of the pathway. Whether ERK1 and ERK2 specify functional differences or are in contrast functionally redundant, constitutes an ongoing debate despite the huge amount of studies performed to date. In this review we compiled data on ERK1 vs. ERK2 gene structures, protein sequences, expression levels, structural and molecular mechanisms of activation and substrate recognition. We have also attempted to perform a rigorous analysis of studies regarding the individual roles of ERK1 and ERK2 by the means of morpholinos, siRNA, and shRNA silencing as well as gene disruption or gene replacement in mice. Finally, we comment on a recent study of gene and protein evolution of ERK isoforms as a distinct approach to address the same question. Our review permits the evaluation of the relevance of published studies in the field especially when measurements of global ERK activation are taken into account. Our analysis favors the hypothesis of ERK1 and ERK2 exhibiting functional redundancy and points to the concept of the global ERK quantity, and not isoform specificity, as being the essential determinant to achieve ERK function.
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BackgroundMethodInfluentialMultiple sequence alignment with hierarchical clustering
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Metadata
- Authors
- Buscà, R., Pouysségur, J., & Lenormand, P.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2016-06-08
- Volume
- 4
- Pages
- 53-53
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W2410865989
- Cited by
- 284
- References
- 170
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- gold
- Funders
- Fondation ARC pour la Recherche sur le Cancer (333831)
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- Buscà, R., Pouysségur, J., & Lenormand, P. (2016). ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy? Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2016.00053
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