The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Tetraspanins Function as Regulators of Cellular Signaling
Open accessAbstract
Tetraspanins are molecular scaffolds that distribute proteins into highly organized microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have identified interactions between tetraspanins and signaling molecules, finding unique downstream cellular consequences. In this review, we will explore these interactions as well as the specific cellular responses to signal activation, focusing on tetraspanin regulation of adhesion-mediated (integrins/FAK), receptor-mediated (EGFR, TNF-α, c-Met, c-Kit), and intracellular signaling (PKC, PI4K, β-catenin). Additionally, we will summarize our current understanding for how tetraspanin post-translational modifications (palmitoylation, N-linked glycosylation, and ubiquitination) can regulate signal propagation. Many of the studies outlined in this review suggest that tetraspanins offer a potential therapeutic target to modulate aberrant signal transduction pathways that directly impact a host of cellular behaviors and disease states.
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Tetraspanin functions and associated microdomains
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“TEMs consist of homophilic and heterophilic interactions amongst tetraspanins, interactions between tetraspanins and other membrane proteins, as well as interactions between tetraspanins and proteins at the membrane/cytoplasm interface (Hemler, 2005; Charrin et al., 2009, 2014; Stipp, 2010).”
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Miranzadeh Mahabadi, H., & Taghibiglou, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197058 · Cited by 52
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Yang, J., Guo, F., Chin, H. S., Chen, G. B., Ang, C. H., Lin, Q., Hong, W., & Fu, N. Y. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112065 · Cited by 22
Metadata
- Authors
- Termini, C. M., & Gillette, J. M.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2017-04-06
- Volume
- 5
- Pages
- 34-34
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W2605205945
- Cited by
- 266
- References
- 149
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Termini, C. M., & Gillette, J. M. (2017). Tetraspanins Function as Regulators of Cellular Signaling. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2017.00034
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
