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Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction

Miranzadeh Mahabadi, Hajar, Taghibiglou, Changiz·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21197058PMC PMC7583789
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Abstract

Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein most abundantly found in the outer leaflet of the plasma membrane (PM) in the central nervous system (CNS). PrPc misfolding causes neurodegenerative prion diseases in the CNS. PrPc interacts with a wide range of protein partners because of the intrinsically disordered nature of the protein’s N-terminus. Numerous studies have attempted to decipher the physiological role of the prion protein by searching for proteins which interact with PrPc. Biochemical characteristics and biological functions both appear to be affected by interacting protein partners. The key challenge in identifying a potential interacting partner is to demonstrate that binding to a specific ligand is necessary for cellular physiological function or malfunction. In this review, we have summarized the intracellular and extracellular interacting partners of PrPc and potential consequences of their binding. We also briefly describe prion disease-related mutations at the end of this review.

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Metadata

Authors
Miranzadeh Mahabadi, H., & Taghibiglou, C.
Affiliations
Department of Anatomy, Physiology, Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
ORCID
Taghibiglou, Changiz
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-09-25
Volume
21
Issue
19
Pages
7058
ISSN
1422-0067
DOI
10.3390/ijms21197058
PMC
PMC7583789
Cited by
52
References
12
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Natural Sciences and Engineering Research Council of Canada (414612)

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