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Cited by 58Lipid metabolism and biosynthesisSphingolipid Metabolism and SignalingCellular transport and secretion

Regulation of Membrane Turnover by Phosphatidic Acid: Cellular Functions and Disease Implications

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Thakur, Rajan, Naik, Amruta, Panda, Aniruddha, Raghu, Padinjat·2019·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2019.00083PMC PMC6559011
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Abstract

Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an intermediate in phospholipid biosynthesis. In addition to its role on lipid biosynthesis, PA has been proposed to act as a signalling molecule that modulates several aspects of cell biology including membrane transport. PA can be generated in eukaryotic cells by several enzymes whose activity is regulated in the context of signal transduction and enzymes that can metabolize PA thus terminating its signalling activity have also been described. Further, several studies have identified PA binding proteins and changes in their activity are proposed to be mediators of the signalling activity of this lipid. Together these enzymes and proteins constitute a PA signalling toolkit that mediates the signalling functions of PA in cells. Recently, a number of novel genetic models for the analysis of PA function in vivo and analytical methods to quantify PA levels in cells have been developed and promise to enhance our understanding of PA functions. Studies of several elements of the PA signalling toolkit in a single cell type have been performed and are presented to provide a perspective on our understanding of the biochemical and functional organization of pools of PA in a eukaryotic cell. Finally, we also provide a perspective on the potential role of PA in human disease, synthesizing studies from model organisms, human disease genetics and analysis using recently developed PLD inhibitors.

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Cited by

Sorted by citations

Authors
Thakur, R., Naik, A., Panda, A., & Raghu, P.
Affiliations
National Centre for Biological Sciences (IN)
Corresponding author
Raghu, Padinjat
ORCID
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2019-06-04
Volume
7
Pages
83-83
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2019.00083
PMC
PMC6559011
OpenAlex
W2949023360
Cited by
58
References
3
Citations by year
2026: 8 · 2025: 8 · 2024: 14 · 2023: 6 · 2022: 15 · 2021: 2 · 2020: 4 · 2019: 1
FWCI
0.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • DBT India Alliance
  • National Centre for Biological Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
phosphatidic acid, membrane turnover, lipid signaling, phospholipid synthesis, phosphatidate phosphohydrolase, membrane transport, lipid metabolism, human disease

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