The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency
Open accessAbstract
from embryonic stem cells (ESCs), induced PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for their two unique characteristics: the ability to give rise to all somatic lineages and the self-renewal capacity. Numerous intrinsic signaling pathways contribute to the maintenance of the pluripotency state of stem cells by tightly controlling key transcriptional regulators of stemness including sex determining region Y box 2 (Sox-2), octamer-binding transcription factor (Oct)3/4, krueppel-like factor 4 (Klf-4), Nanog, and c-Myc. Signaling by fibroblast growth factor (FGF) is of critical importance in regulating stem cells pluripotency. The FGF family is comprised of 22 ligands that interact with four FGF receptors (FGFRs). FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism. FGF signaling is mediated by the activation of RAS - mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT, Phospholipase C Gamma (PLCγ), and signal transducers and activators of transcription (STAT), which intersects and synergizes with other signaling pathways such as Wnt, retinoic acid (RA) and transforming growth factor (TGF)-β signaling. In the current review, we summarize the role of FGF signaling in the maintenance of pluripotency state of stem cells through regulation of key transcriptional factors.
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Cross-phyla protein annotation by structural prediction and alignment
Ruperti, F., Papadopoulos, N., Musser, J. M., Mirdita, M., Steinegger, M., & Arendt, D. (2023) · Genome Biology · doi:10.1186/s13059-023-02942-9 · Cited by 38
Research progress on interferon and cellular senescence
Wang, D., Chen, K., Wang, Z., Wu, H., & Li, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202400808rr · Cited by 23
Bertucci, T., Bowles, K. R., Lotz, S., Bheda, S., Qi, L., Farjood, F., Whitton, K., Goderie, S. K., Borden, S., Rossi, A., et al. (2023) · doi:10.1101/2023.07.11.548571 · Cited by 22
The role of bmp- and fgf signaling modulating mouse proepicardium cell fate
Garcia-Padilla, C., Hernandez-Torres, F., Lozano-Velasco, E., Dueñas, A., Muñoz-Gallardo, M. D. M., Garcia-Valencia, I. S., Palencia-Vincent, L., Aranega, A., & Franco, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.757781 · Cited by 10
Metadata
- Authors
- Mossahebi-Mohammadi, M., Quan, M., Zhang, J.-S., & Li, X.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2020-02-18
- Volume
- 8
- Pages
- 79-79
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W3006012565
- Cited by
- 305
- References
- 91
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- gold
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