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Cited by 209

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment

Open access
Wu, Peijie, Gao, Wei, Su, Miao, Nice, Edouard C., Zhang, Wenhui, Lin, Jie, Xie, Na·2021·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2021.641469
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Abstract

Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic strategies have been developed for various cancers, including chemotherapy, radiotherapy, and immunotherapy, resistance to these treatments frequently impedes the clinical outcomes. Besides the active resistance driven by genetic and epigenetic alterations in tumor cells, the tumor microenvironment (TME) has also been reported to be a crucial regulator in tumorigenesis, progression, and resistance. Here, we propose that the adaptive mechanisms of tumor resistance are closely connected with the TME rather than depending on non-cell-autonomous changes in response to clinical treatment. Although the comprehensive understanding of adaptive mechanisms driven by the TME need further investigation to fully elucidate the mechanisms of tumor therapeutic resistance, many clinical treatments targeting the TME have been successful. In this review, we report on recent advances concerning the molecular events and important factors involved in the TME, particularly focusing on the contributions of the TME to adaptive resistance, and provide insights into potential therapeutic methods or translational medicine targeting the TME to overcome resistance to therapy in clinical treatment.

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Metadata

Authors
Wu, P., Gao, W., Su, M., Nice, E. C., Zhang, W., Lin, J., & Xie, N.
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2021-03-01
Volume
9
Pages
641469-641469
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2021.641469
OpenAlex
W3135125547
Cited by
209
References
72
FWCI
11.33
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment. https://app.cochat.ai/papers/10.3389/fcell.2021.641469
The paper
Wu, P., Gao, W., Su, M., Nice, E. C., Zhang, W., Lin, J., & Xie, N. (2021). Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2021.641469

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.