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Cited by 73Cholesterol and Lipid MetabolismCancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Intracellular Cholesterol Synthesis and Transport

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Shi, Qingyang, Chen, Jiahuan, Zou, Xiaodong, Tang, Xiaochun·2022·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2022.819281PMC PMC8978673
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Abstract

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.

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  • Increased cholesterol levels can be caused by enhanced glycolysis and the subsequent synthesis of acetyl-CoA, a source of cholesterol synthesis.

    “Increased cholesterol levels can be caused by enhanced glycolysis and the subsequent synthesis of acetyl-CoA, a source of cholesterol synthesis,39”

    From ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes (2023) · cites this paper as [39]

    The Introduction’s “Cholesterol Synthesis” section identifies acetyl-CoA as a starting material for cholesterol synthesis. It does not say that enhanced glycolysis increases acetyl-CoA production or causes cholesterol levels to rise; searches for glycolysis and that proposed link found no supporting passage. Page numbers were not available in our copy. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Shi, Q., Chen, J., Zou, X., & Tang, X.
Affiliations
Jilin University (CN)
Corresponding author
Tang, Xiaochun
ORCID
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2022-03-21
Volume
10
Pages
819281-819281
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2022.819281
PMC
PMC8978673
OpenAlex
W4220955668
Cited by
73
References
1
Citations by year
2026: 14 · 2025: 19 · 2024: 19 · 2023: 17 · 2022: 4
FWCI
3.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Department of Science and Technology of Jilin Province
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
intracellular cholesterol, cholesterol biosynthesis, cholesterol homeostasis, cholesterol transport, lipid transfer proteins, cholesterol esterification, cholesterol export, cholesterol absorption, membrane contact sites

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