The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases
Open accessAbstract
Neutrophils, complement system and skin collectively represent the main elements of the innate immune system, the first line of defence of the host against many common microorganisms. Bacterial pathogens have evolved strategies to counteract all these defence activities. Specifically, Staphylococcus aureus, a major human pathogen, secretes a variety of immune evasion molecules including proteases, which cleave components of the innate immune system or disrupt the integrity of extracellular matrix and intercellular connections of tissues. Additionally, S. aureus secretes proteins that can activate host zymogens which, in turn, target specific defence components. Secreted proteins can also inhibit the anti-bacterial function of neutrophils or complement system proteases, potentiating S. aureus chances of survival. Here, we review the current understanding of these proteases and modulators of host proteases in the functioning of innate immunity and describe the importance of these mechanisms in the pathology of staphylococcal diseases.
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Cites
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972
Matrix metalloproteinases as modulators of inflammation and innate immunity
Parks, W. C., Wilson, C. L., & López-Boado, Y. S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1418 · Cited by 1,929
Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584 · cited 1×
“Lastly, some S. aureus secreted molecules can bind and inhibit neutrophil serine proteases which are important for several functions including the regulation of extracellular trap formation (Hu, 2012; Kolaczkowska et al., 2015).”
BackgroundBonora, M., Wieckowski, M. R., Chinopoulos, C., Kepp, O., Kroemer, G., Galluzzi, L., & Pinton, P. (2015) · Oncogene · doi:10.1038/onc.2014.96 · Cited by 330
The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing
Zinkernagel, A. S., Timmer, A. M., Pence, M. A., Locke, J. B., Buchanan, J. T., Turner, C. E., Mishalian, I., Sriskandan, S., Hanski, E., & Nizet, V. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.07.002 · Cited by 184 · cited 1×
“As consequence, SpyCEP impairs the recruitment of neutrophils at the site of infection and bacterial clearance (Zinkernagel et al., 2008).”
Background
Cited by
Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies
Schilcher, K., & Horswill, A. R. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00026-19 · Cited by 706
The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341
Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms
Touaitia, R., Mairi, A., Ibrahim, N. A., Basher, N. S., Idres, T., & Touati, A. (2025) · Antibiotics · doi:10.3390/antibiotics14050470 · Cited by 273
Coconut Palm: Food, Feed, and Nutraceutical Properties
Mat, K., Abdul Kari, Z., Rusli, N. D., Che Harun, H., Wei, L. S., Rahman, M. M., Mohd Khalid, H. N., Mohd Ali Hanafiah, M. H., Mohamad Sukri, S. A., Raja Khalif, R. I. A., et al. (2022) · Animals · doi:10.3390/ani12162107 · Cited by 92
Metadata
- Authors
- Pietrocola, G., Nobile, G., Rindi, S., & Speziale, P.
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2017-05-05
- Volume
- 7
- Pages
- 166-166
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W2611236744
- Cited by
- 179
- References
- 6
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pietrocola, G., Nobile, G., Rindi, S., & Speziale, P. (2017). Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2017.00166
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
