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Cited by 41Research on Leishmaniasis StudiesLeprosy Research and TreatmentCircadian rhythm and melatonin

Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression

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Fernandes, Juliane Cristina Ribeiro, Aoki, Juliana Ide, Maia Acuña, Stephanie, Zampieri, Ricardo Andrade, Markus, Regina P., Floeter-Winter, Lucile Maria, Muxel, Sandra Marcia·2019·Frontiers in Cellular and Infection Microbiology
DOI 10.3389/fcimb.2019.00060PMC PMC6435487
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Abstract

Leishmaniases are neglected diseases that cause a large spectrum of clinical manifestations, from cutaneous to visceral lesions. The initial steps of the inflammatory response involve the phagocytosis of Leishmania and the parasite replication inside the macrophage phagolysosome. Melatonin, the darkness-signaling hormone, is involved in modulation of macrophage activation during infectious diseases, controlling the inflammatory response against parasites. In this work, we showed that exogenous melatonin treatment of BALB/c macrophages reduced L. amazonensis infection and modulated host microRNA (miRNA) expression profile, as well as cytokine production such as IL-6, MCP-1/CCL2, and, RANTES/CCL9. The role of one of the regulated miRNA (miR-294-3p) in L. amazonensis BALB/c infection was confirmed with miRNA inhibition assays, which led to increased expression levels of Tnf and Mcp-1/Ccl2 and diminished infectivity. Additionally, melatonin treatment or miR-30e-5p and miR-302d-3p inhibition increased nitric oxide synthase 2 (Nos2) mRNA expression levels and nitric oxide (NO) production, altering the macrophage activation state and reducing infection. Altogether, these data demonstrated the impact of melatonin treatment on the miRNA profile of BALB/c macrophage infected with L. amazonensis defining the infection outcome.

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  • Downregulation of miR-30e-5p and miR-302d-3p increases Nos2 mRNA expression and NO production.

    “Downregulation of miR-30e-5p and miR-302d-3p increased nitric oxide synthase 2 (Nos2) mRNA expression and nitric oxide (NO) production [131].”

    From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [131]

    The Results section (page not available) reports that inhibiting miR-30e-5p and miR-302d-3p increased Nos2 mRNA in infected macrophages. It does not report increased NO production after those inhibitions; the Discussion attributes increased Nos2 expression and NO production to melatonin treatment instead. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Fernandes, J. C. R., Aoki, J. I., Maia Acuña, S., Zampieri, R. A., Markus, R. P., Floeter-Winter, L. M., & Muxel, S. M.
Affiliations
Universidade de São Paulo (BR)
ORCID
Venue
Frontiers in Cellular and Infection Microbiology
Publisher
Frontiers Media SA
Published
2019-03-20
Volume
9
Pages
60-60
ISSN
2235-2988 (ISSN-L)
DOI
10.3389/fcimb.2019.00060
PMC
PMC6435487
OpenAlex
W2923873858
Cited by
41
References
5
Citations by year
2026: 2 · 2025: 2 · 2024: 8 · 2023: 7 · 2022: 10 · 2021: 4 · 2020: 6 · 2019: 2
FWCI
5.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo (2014/50717-1, 2018/24693-9)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
melatonin, Leishmania amazonensis, cutaneous leishmaniasis, microRNA, miR-30e-5p, macrophage activation, nitric oxide, nitric oxide synthase 2, TNF-α, CCL2/MCP-1, interleukin-6, host-parasite interactions, innate immune response
MeSH terms
Animals, Cells, Cultured, Disease Models, Animal, Female, Gene Expression Regulation, Immunity, Innate, Immunologic Factors, Leishmania, Leishmaniasis, Macrophages, Melatonin, Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, Chemokine CCL2, MicroRNAs, Nitric Oxide Synthase Type II

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