MicroRNA let-7c Regulates Macrophage Polarization
Open accessAbstract
Macrophages demonstrate a high level of plasticity, with the ability to undergo dynamic transition between M1 and M2 polarized phenotypes. The role of microRNAs (miRNAs) in regulating macrophage polarization has been largely undefined. In this study, we found that miRNA let-7c is expressed at a higher level in M-BMM (M2 macrophages) than in GM-BMM (M1 macrophages). let-7c levels are also greater in alveolar macrophages from fibrotic lungs as compared with those from normal lungs. let-7c expression was decreased when M-BMM converted to GM-BMM, whereas it increased when GM-BMM converted to M-BMM. LPS stimulation reduced let-7c expression in M-BMM. We found that overexpression of let-7c in GM-BMM diminished M1 phenotype expression while promoting polarization to the M2 phenotype. In contrast, knockdown of let-7c in M-BMM promoted M1 polarization and diminished M2 phenotype expression. We found that let-7c targets C/EBP-δ, a transcriptional factor that plays an important role in inflammatory response. Furthermore, we found that let-7c regulates bactericidal and phagocytic activities of macrophages, two functional phenotypes implicated in macrophage polarization. Our data suggest that the miRNA let-7c plays an important role in regulating macrophage polarization.
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let-7c expression is suppressed by LPS, whereas its upregulation results in a change from the M1 to M2 phenotype by targeting the C/EBP-δ transcription factor.
“Expression of let-7c is suppressed by LPS, whereas its upregulation results in a change from the M1 to M2 phenotype by targeting the C/EBP-δ transcription factor [110].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [110]
Overexpression of let-7c promotes the M2 phenotype and increases phagocytosis of apoptotic cells, whereas knockdown decreases it.
“Overexpression of let-7c, by promoting the M2 phenotype, increases phagocytosis of apoptotic cells, whereas its knockdown decreases it [110].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [110]
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Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · see citing works
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,003 · see citing works
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., et al. (2008) · Nature · doi:10.1038/nature07511 · Cited by 2,349 · see citing works
Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,336 · see citing works
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Lawrence, T., & Natoli, G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3088 · Cited by 2,284 · see citing works
Grishok, A., Pasquinelli, A. E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D. L., Fire, A., Ruvkun, G., & Mello, C. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00431-7 · Cited by 1,600 · see citing works
Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.014 · Cited by 1,374 · see citing works
Small non-coding RNAs in animal development
Stefani, G., & Slack, F. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2347 · Cited by 1,361 · see citing works
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
Krausgruber, T., Blazek, K. D., Smallie, T., Alzabin, S., Lockstone, H. E., Sahgal, N., Hussell, T., Feldmann, M., & Udalova, I. A. (2011) · Nature Immunology · doi:10.1038/ni.1990 · Cited by 1,296 · see citing works
Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., et al. (2010) · Nature Immunology · doi:10.1038/ni.1920 · Cited by 1,156 · see citing works
Verreck, F. A. W., de Boer, T., Langenberg, D. M. L., Hoeve, M. A., Kramer, M., Vaisberg, E., Kastelein, R., Kolk, A. H. J., Malefyt, R. D. W., & Ottenhoff, T. H. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400983101 · Cited by 969 · see citing works
Differential macrophage programming in the tumor microenvironment
Ruffell, B., Affara, N. I., & Coussens, L. M. (2012) · Trends in Immunology · doi:10.1016/j.it.2011.12.001 · Cited by 855 · see citing works
Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787 · see citing works
Ruffell, D., Mourkioti, F., Gambardella, A., Kirstetter, P., Lopez, R. G., Rosenthal, N., & Nerlov, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908641106 · Cited by 626 · see citing works
How Toll-like receptors signal: what we know and what we don’t know
O'Neill, L. A. J. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.012 · Cited by 614 · see citing works
The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress
O'Neill, L. A. J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00701.x · Cited by 612 · see citing works
Fleetwood, A. J., Lawrence, T., Hamilton, J. A., & Cook, A. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5245 · Cited by 607 · see citing works
let-7 microRNAs in development, stem cells and cancer
Büssing, I., Slack, F. J., & Großhans, H. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.07.001 · Cited by 604 · see citing works
The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs
Androulidaki, A., Iliopoulos, D., Arranz, A., Doxaki, C., Schworer, S., Zacharioudaki, V., Margioris, A. N., Tsichlis, P. N., & Tsatsanis, C. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.024 · Cited by 581 · see citing works
Obstacles and opportunities for understanding macrophage polarization
Murray, P. J., & Wynn, T. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710409 · Cited by 558 · see citing works
Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models
Lacey, D. C., Achuthan, A. A., Fleetwood, A. J., Dinh, H., Roiniotis, J., Scholz, G. M., Chang, M. W., Beckman, S. K., Cook, A. D., & Hamilton, J. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103426 · Cited by 528 · see citing works
A Vicious Circle of Alveolar Macrophages and Fibroblasts Perpetuates Pulmonary Fibrosis via CCL18
Prasse, A., Pechkovsky, D. V., Toews, G. B., Jungraithmayr, W., Kollert, F., Goldmann, T., Vollmer, E., Müller-Quernheim, J., & Zissel, G. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1518oc · Cited by 497 · see citing works
Epigenetic regulation of the alternatively activated macrophage phenotype
Ishii, M., Wen, H., Corsa, C. A. S., Liu, T., Coelho, A. L., Allen, R., Carson, W. F., Cavassani, K. A., Li, X., Lukacs, N. W., et al. (2009) · Blood · doi:10.1182/blood-2009-04-217620 · Cited by 496 · see citing works
Chen, X., Splinter, P. L., O’Hara, S. P., & LaRusso, N. F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702633200 · Cited by 480 · see citing works
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis
Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1719oc · Cited by 466 · see citing works
Zhuang, G., Meng, C., Guo, X., Cheruku, P. S., Shi, L., Xu, H., Li, H., Wang, G., Evans, A. R., Safe, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.087817 · Cited by 428 · see citing works
Fadok, V. A., Warner, M. L., Bratton, D. L., & Henson, P. M. (1998) · PubMed · Cited by 406 · see citing works
Puig‐Kröger, A., Sierra‐Filardi, E., Domínguez‐Soto, Á., Samaniego, R., Corcuera, M. T., Gómez, F., Ratnam, M., Sánchez‐Mateos, P., & Corbí, A. L. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2050 · Cited by 389 · see citing works
Identifying Functional MicroRNAs in Macrophages with Polarized Phenotypes
Graff, J. W., Dickson, A. M., Clay, G., McCaffrey, A. P., & Wilson, M. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.327031 · Cited by 367 · see citing works
Fadok, V. A., Warner, M. L., Bratton, D. L., & Henson, P. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6250 · Cited by 353 · see citing works
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP
Byström, J., Evans, I. M., Newson, J., Stables, M. J., Toor, I. S., van Rooijen, N., Crawford, M., Colville‐Nash, P., Farrow, S. N., & Gilroy, D. W. (2008) · Blood · doi:10.1182/blood-2007-12-129767 · Cited by 335 · see citing works
MicroRNA-125b Potentiates Macrophage Activation
Chaudhuri, A. A., So, A. Y.-L., Sinha, N., Gibson, W. S. J., Taganov, K. D., O’Connell, R. M., & Baltimore, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102001 · Cited by 327 · see citing works
MicroRNAs and cardiac pathology
Latronico, M. V. G., & Condorelli, G. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.56 · Cited by 318 · see citing works
Schulte, L. N., Eulalio, A., Mollenkopf, H., Reinhardt, R., & Vogel, J. (2011) · EMBO Journal · doi:10.1038/emboj.2011.94 · Cited by 316 · see citing works
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
Mullican, S. E., Gaddis, C. A., Alenghat, T., Nair, M. G., Giacomin, P. R., Everett, L. J., Feng, D., Steger, D. J., Schug, J., Artis, D., et al. (2011) · Genes & Development · doi:10.1101/gad.175950.111 · Cited by 314 · see citing works
Fleetwood, A. J., Dinh, H., Cook, A. D., Hertzog, P. J., & Hamilton, J. A. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1108702 · Cited by 312 · see citing works
Litvak, V., Ramsey, S. A., Rust, A. G., Zak, D. E., Kennedy, K. A., Lampano, A. E., Nykter, M., Shmulevich, I., & Aderem, A. (2009) · Nature Immunology · doi:10.1038/ni.1721 · Cited by 295 · see citing works
Participation of miR-200 in Pulmonary Fibrosis
Yang, S., Banerjee, S., de Freitas, A., Sanders, Y. Y., Ding, Q., Matalon, S., Thannickal, V. J., Abraham, E. H., & Liu, G. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.005 · Cited by 258 · see citing works
Self-citationMicroRNAs in Immune Response and Macrophage Polarization
Liu, G., & Abraham, E. H. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300068 · Cited by 243 · see citing works
Self-citationProinflammatory Role for let-7 MicroRNAS in Experimental Asthma
Polikepahad, S., Knight, J. M., Naghavi, A. O., Oplt, T., Creighton, C. J., Shaw, C. A., Benham, A. L., Kim, J. K., Soibam, B., Harris, R. A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145698 · Cited by 242 · see citing works
Pottelberge, G. R. V., Mestdagh, P., Bracke, K. R., Thas, O., van Durme, Y. M. T. A., Joos, G., Vandesompele, J., & Brusselle, G. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0304oc · Cited by 236 · see citing works
12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Uderhardt, S., i, M. H., Oskolkova, O., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R. E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.010 · Cited by 235 · see citing works
Lung environment determines unique phenotype of alveolar macrophages
Guth, A., Janssen, W. J., Bosio, C. M., Crouch, E. C., Henson, P. M., & DOW, S. W. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90625.2008 · Cited by 213 · see citing works
Sierra‐Filardi, E., Vega, M. A., Sánchez‐Mateos, P., Corbí, A. L., & Puig‐Kröger, A. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.020 · Cited by 204 · see citing works
Baran, C. P., Opalek, J. M., McMaken, S., Newland, C. A., O’Brien, J. M., Hunter, M. G., Bringardner, B. D., Monick, M. M., Brigstock, D. R., Stromberg, P. C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200609-1279oc · Cited by 196 · see citing works
MicroRNAs in Diabetes: Tiny Players in Big Disease
Pandey, A. K., Agarwal, P., Kaur, K., & Datta, M. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000218169 · Cited by 181 · see citing works
Park, S., Jung, M.-Y., Lee, S.-J., Kang, K.-B., Gratchev, A. N., Riabov, V., Kzhyshkowska, J. G., & Kim, I. (2009) · Journal of Cell Science · doi:10.1242/jcs.049569 · Cited by 157 · see citing works
Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells
Jakubzick, C., Choi, E. S., Joshi, B. H., Keane, M. P., Kunkel, S. L., Puri, R. K., & Hogaboam, C. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2684 · Cited by 157 · see citing works
Hu, G., Zhou, R., Liu, J., Gong, A., Eischeid, A. N., Dittman, J. W., & Chen, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804362 · Cited by 119 · see citing works
Epigenetic control of macrophage polarization
Takeuch, O., & Akira, S. (2011) · European Journal of Immunology · doi:10.1002/eji.201141792 · Cited by 107 · see citing works
Differential Role for c-Rel and C/EBPβ/δ in TLR-Mediated Induction of Proinflammatory Cytokines
Lu, Y., Kim, I., Lye, E., Shen, F., Suzuki, N., Suzuki, S., Gerondakis, S., Akira, S., Gaffen, S. L., Yeh, W., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802971 · Cited by 106 · see citing works
Hou, W., Tian, Q., Steuerwald, N., Schrum, L. W., & Bonkovsky, H. L. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.06.001 · Cited by 103 · see citing works
Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy
Liao, X., Haldar, S. M., Lu, Y., Jeyaraj, D., Paruchuri, K., Nahori, M., Cui, Y., Kaestner, K. H., & Jain, M. K. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.04.008 · Cited by 102 · see citing works
Regulation of dendritic cell activation by microRNA let-7c and BLIMP1
Kim, S. J., Gregersen, P. K., & Diamond, B. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64712 · Cited by 89 · see citing works
Maitra, U., Gan, L., Chang, S., & Li, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003300 · Cited by 82 · see citing works
Intracellular HMGB1 Negatively Regulates Efferocytosis
Banerjee, S., de Freitas, A., Friggeri, A., Zmijewski, J. W., Liu, G., & Abraham, E. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101500 · Cited by 68 · see citing works
Self-citationEscribese, M. M., Sierra‐Filardi, E., Nieto, C., Samaniego, R., Sánchez‐Torres, C., Matsuyama, T., Calderón‐Gómez, E., Vega, M. A., Salas, A., Sánchez‐Mateos, P., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201064 · Cited by 57 · see citing works
Identification of TLT2 as an Engulfment Receptor for Apoptotic Cells
de Freitas, A., Banerjee, S., Xie, N., Cui, H., Davis, K. I., Friggeri, A., Fu, M., Abraham, E. H., & Liu, G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200020 · Cited by 37 · see citing works
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Flagged first, then by citations
1 of the 62 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [21]Yang S Xie N Cui H Banerjee S Abraham E Thannickal VJ Liu G miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis Faseb J 2012 PMC3425828 22661007
Cited by
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Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981 · see citing works
Diversity, Mechanisms, and Significance of Macrophage Plasticity
Locati, M., Curtale, G., & Mantovani, A. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012718 · Cited by 2,199 · see citing works
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
Wang, N., Liang, H., & Zen, K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00614 · Cited by 1,997 · see citing works
Microglial and macrophage polarization—new prospects for brain repair
Hu, X., Leak, R. K., Shi, Y., Suenaga, J., Gao, Y., Zheng, P., & Chen, J. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.207 · Cited by 1,456 · see citing works
Zhou, D., Huang, C., Lin, Z., Zhan, S., Kong, L., Fang, C., & Li, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.004 · Cited by 778 · see citing works
Paul, S., & Candelario‐Jalil, E. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113518 · Cited by 762 · see citing works
Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration
Das, A., Sinha, M., Datta, S., Abas, M., Chaffee, S. M., Sen, C. K., & Roy, S. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.06.001 · Cited by 747 · see citing works
Macrophages: Their role, activation and polarization in pulmonary diseases
Arora, S., Dev, K., Agarwal, B., Das, P., & Syed, M. A. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.11.001 · Cited by 640 · see citing works
MicroRNA Regulation of Atherosclerosis
Feinberg, M. W., & Moore, K. J. (2016) · Circulation Research · doi:10.1161/circresaha.115.306300 · Cited by 630 · see citing works
Essandoh, K., Li, Y., Huo, J., & Fan, G. (2016) · Shock · doi:10.1097/shk.0000000000000604 · Cited by 603 · see citing works
Targeting Macrophages in Cancer: From Bench to Bedside
Poh, A. R., & Ernst, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00049 · Cited by 497 · see citing works
Myers, K. V., Amend, S. R., & Pienta, K. J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1022-2 · Cited by 482 · see citing works
Macrophage polarization and allergic asthma
Saradna, A., Do, D. C., Kumar, S. A., Fu, Q.-L., & Gao, P. (2017) · Translational research · doi:10.1016/j.trsl.2017.09.002 · Cited by 428 · see citing works
Chen, X., Tang, J., Shuai, W., Meng, J., Feng, J., & Han, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01378-2 · Cited by 428 · see citing works
Macrophage Plasticity and Polarization in Liver Homeostasis and Pathology
Sica, A., Invernizzi, P., & Mantovani, A. (2014) · Hepatology · doi:10.1002/hep.26754 · Cited by 422 · see citing works
MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing
He, X.-N., Dong, Z., Cao, Y.-N., Wang, H., Liu, S.-Y., Liao, L., Jin, Y., Yuan, L., & Li, B. (2019) · Stem Cells International · doi:10.1155/2019/7132708 · Cited by 372 · see citing works
Macrophage polarization and meta-inflammation
Li, C., Xu, M. M., Wang, K., Adler, A. J., Vella, A. T., & Zhou, B. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.004 · Cited by 369 · see citing works
Tan, Z., Xie, N., Cui, H., Moellering, D. R., Abraham, E. H., Thannickal, V. J., & Liu, G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402469 · Cited by 320 · see citing works
Self-citationMolecular and epigenetic basis of macrophage polarized activation
Porta, C., Riboldi, E., Ippolito, A., & Sica, A. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.003 · Cited by 319 · see citing works
Role of Human Milk Bioactives on Infants' Gut and Immune Health
Carr, L. E., Virmani, M., da Rosa, F. T., Munblit, D., Matazel, K. S., Elolimy, A. A., & Yeruva, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.604080 · Cited by 329 · see citing works
Chu, F., Shi, M., Zheng, C., Shen, D., Zhu, J., Zheng, X., & Cui, L. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.02.015 · Cited by 304 · see citing works
The roles of macrophage polarization in the host immune response to sepsis
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Njock, M., Cheng, H. S., Dang, L. T. H., Nazari-Jahantigh, M., Lau, A. C., Boudreau, É., Roufaiel, M., Cybulsky, M. I., Schober, A., & Fish, J. E. (2015) · Blood · doi:10.1182/blood-2014-11-611046 · Cited by 270 · see citing works
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Baer, C., Squadrito, M. L., Laoui, D., Thompson, D., Hansen, S. K., Kiialainen, A., Hoves, S., Ries, C. H., Ooi, C.-H., & De Palma, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3371 · Cited by 259 · see citing works
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Banerjee, S., Cui, H., Xie, N., Tan, Z., Yang, S., Icyuz, M., Thannickal, V. J., Abraham, E., & Liu, G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426866 · Cited by 258 · see citing works
Self-citationThe role of Kupffer cells in hepatic diseases
Li, P., He, K., Li, J., Liu, Z., & Gong, J. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.02.018 · Cited by 232 · see citing works
Slota, J. A., & Booth, S. A. (2019) · Non-Coding RNA · doi:10.3390/ncrna5020035 · Cited by 233 · see citing works
Mitchell, R., Mellows, B., Sheard, J., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M.-T., Tomkins, J. E., Denecke, B., Musante, L., et al. (2019) · Stem cell research & therapeutics · doi:10.1186/s13287-019-1213-1 · Cited by 186 · see citing works
MicroRNAs in kidney injury and disease
Mahtal, N., Lenoir, O., Tinel, C., Anglicheau, D., & Tharaux, P. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00608-6 · Cited by 215 · see citing works
Transcriptional Regulation of Macrophages Polarization by MicroRNAs
Li, H., Jiang, T., Li, M., Zheng, X., & Zhao, G.-J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01175 · Cited by 204 · see citing works
Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases
Dort, J., Fabre, P., Molina, T., & Dumont, N. A. (2019) · Stem Cells International · doi:10.1155/2019/4761427 · Cited by 182 · see citing works
Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia
Amici, S. A., Dong, J., & Guerau‐de‐Arellano, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01520 · Cited by 192 · see citing works
Tan, Z., Xie, N., Banerjee, S., Cui, H., Fu, M., Thannickal, V. J., & Liu, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.603589 · Cited by 186 · see citing works
Self-citationMicroRNAs as Molecular Switches in Macrophage Activation
Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 182 · see citing works
Role of MicroRNAs in Parkinson’s Disease
Goh, S. Y., Chao, Y., Dheen, S. T., Tan, E., & Tay, S. S. W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225649 · Cited by 179 · see citing works
Extracellular Vesicle-Mediated Communication Within Host-Parasite Interactions
Wu, Z., Wang, L., Li, J., Wang, L., Wu, Z., & Sun, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03066 · Cited by 172 · see citing works
Wang, Z., Brandt, S., Medeiros, A., Wang, S., Wu, H., Dent, A., & Serezani, C. H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0115855 · Cited by 169 · see citing works
Ni, J., Wang, X., Chen, S., Liu, H., Wang, Y., Xu, X., Cheng, J. G., Jia, J., & Zhen, X. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.014 · Cited by 169 · see citing works
The Many Faces of C/EBPδ and their Relevance for Inflammation and Cancer
Balamurugan, K., & Sterneck, E. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.7224 · Cited by 166 · see citing works
Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi
Zamanian, M., Fraser, L. M., Agbedanu, P. N., Harischandra, H., Moorhead, A. R., Day, T. A., Bartholomay, L. C., & Kimber, M. J. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004069 · Cited by 165 · see citing works
Veremeyko, T., Siddiqui, S., Sotnikov, I., Yung, A., & Ponomarev, E. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081774 · Cited by 145 · see citing works
Biological roles of CCAAT/Enhancer-binding protein delta during inflammation
Ko, C., Chang, W., & Wang, J. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-014-0110-2 · Cited by 157 · see citing works
Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
Khoshnam, S. E., Winlow, W., Farbood, Y., Moghaddam, H. F., & Farzaneh, M. (2017) · Journal of Stroke · doi:10.5853/jos.2016.01368 · Cited by 156 · see citing works
M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment
Bi, Y., Chen, J., Hu, F., Liu, J., Li, M., & Zhao, L. (2019) · Neural Plasticity · doi:10.1155/2019/6724903 · Cited by 153 · see citing works
Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease
Faccini, J., Ruidavets, J., Cordelier, P., Martins, F., Maoret, J.-J., Bongard, V., Ferrières, J., Roncalli, J. G., Elbaz, M., & Vindis, C. (2017) · Scientific Reports · doi:10.1038/srep42916 · Cited by 143 · see citing works
Dual role of arginine metabolism in establishing pathogenesis
Gogoi, M., Datey, A., Wilson, K. T., & Chakravortty, D. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.10.005 · Cited by 142 · see citing works
MicroRNA: Dynamic Regulators of Macrophage Polarization and Plasticity
Self-Fordham, J., Naqvi, A. R., Uttamani, J. R., Kulkarni, V., & Nares, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01062 · Cited by 140 · see citing works
The Basis of Muscle Regeneration
Musarò, A. (2014) · Advances in Biology · doi:10.1155/2014/612471 · Cited by 149 · see citing works
How to reprogram microglia toward beneficial functions
Fumagalli, M., Lombardi, M., Gressèns, P., & Verderio, C. (2018) · Glia · doi:10.1002/glia.23484 · Cited by 134 · see citing works
Cui, H., Banerjee, S., Guo, S., Xie, N., Ge, J., Jiang, D., Zörnig, M., Thannickal, V. J., & Liu, G. (2019) · JCI Insight · doi:10.1172/jci.insight.124522 · Cited by 132 · see citing works
Self-citationmiR-27a regulates inflammatory response of macrophages by targeting IL-10
Xie, N., Cui, H., Banerjee, S., Tan, Z., Salomao, R., Fu, M., Abraham, E., Thannickal, V. J., & Liu, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400203 · Cited by 120 · see citing works
Self-citationWang, J., Xia, J. L., Huang, R., Hu, Y., Fan, J., Shu, Q., & Xu, J. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01937-8 · Cited by 125 · see citing works
Song, H., Yang, Y., Sun, Y., Wei, G., Zheng, H., Chen, Y., Cai, D., Li, C., Ma, Y., Lin, Z., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.09.017 · Cited by 120 · see citing works
Macrophage development and polarization in chronic inflammation.
Motwani, M., & Gilroy, D. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.07.002 · Cited by 108 · see citing works
Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function
Baker, E. W., Kinder, H. A., & West, F. D. (2019) · Brain and Behavior · doi:10.1002/brb3.1214 · Cited by 115 · see citing works
C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS
Pulido-Salgado, M., Vidal-Taboada, J. M., & Saura, J. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.06.003 · Cited by 116 · see citing works
Wu, X., Dai, Y., Yang, Y., Huang, C. Z., Meng, X., Wu, B., & Li, J. (2016) · Immunology · doi:10.1111/imm.12608 · Cited by 116 · see citing works
MicroRNAs and immunity in periodontal health and disease
Luan, X., Zhou, X. C., Naqvi, A. R., Francis, M., Foyle, D., Nares, S., & Diekwisch, T. G. H. (2018) · International Journal of Oral Science · doi:10.1038/s41368-018-0025-y · Cited by 115 · see citing works
Louw, A., Kolar, M. K., Novikova, L. N., Kingham, P. J., Wiberg, M., Kjems, J., & Novikov, L. N. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.011 · Cited by 115 · see citing works
Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors
Cuevas, A., Saavedra, N., Salazar, L. A., & Abdalla, D. S. P. (2013) · Nutrients · doi:10.3390/nu5072314 · Cited by 117 · see citing works
Macrophages and Alcohol-Related Liver Inflammation
Ju, C. H. (2015) · Alcohol research · doi:10.35946/arcr.v37.2.09 · Cited by 109 · see citing works
Kapellos, T. S., & Iqbal, A. J. (2016) · Mediators of Inflammation · doi:10.1155/2016/6591703 · Cited by 104 · see citing works
Harnessing the antitumor potential of macrophages for cancer immunotherapy
Long, K. B., & Beatty, G. L. (2013) · OncoImmunology · doi:10.4161/onci.26860 · Cited by 103 · see citing works
Epigenetic modulation of macrophage polarization- perspectives in diabetic wounds
Mallik, S. B., Jayashree, B. S., & Shenoy, R. R. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.01.015 · Cited by 101 · see citing works
Xie, N., Cui, H., Ge, J., Banerjee, S., Guo, S., Dubey, S., Abraham, E. H., Liu, R.-M., & Liu, G. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00235.2017 · Cited by 99 · see citing works
Self-citationLet-7 microRNA as a potential therapeutic target with implications for immunotherapy
Gilles, M.-E., & Slack, F. J. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1535594 · Cited by 100 · see citing works
Pennathur, S., Pasichnyk, K., Bahrami, N. M., Zeng, L., Febbraio, M., Yamaguchi, I., & Okamura, D. M. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.04.016 · Cited by 94 · see citing works
Wang, Z., Xu, L., Hu, Y.-Y., Huang, Y.-Q., Zhang, Y., Zheng, X.-F., Wang, S.-S., Wang, Y.-F., Yu, Y.-R., Zhang, M., et al. (2016) · Scientific Reports · doi:10.1038/srep25602 · Cited by 86 · see citing works
Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches
Maida, C. D., Norrito, R. L., Rizzica, S., Mazzola, M., Scarantino, E. R., & Tuttolomondo, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126297 · Cited by 92 · see citing works
Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease
Rasheed, M., Liang, J., Wang, C., Deng, Y., & Chen, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094956 · Cited by 94 · see citing works
Fu, S.-P., Chen, S., Pang, Q.-M., Zhang, M., Wu, X.-C., Wan, X., Wan, W.-H., Ao, J., & Zhang, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1014013 · Cited by 89 · see citing works
Lu, L., McCurdy, S., Huang, S., Zhu, X., Peplowska, K., Tiirikainen, M., Boisvert, W. A., & Garmire, L. X. (2016) · Scientific Reports · doi:10.1038/srep37446 · Cited by 83 · see citing works
Jaiswal, A., Reddy, S. S., Maurya, M., Maurya, P., & Barthwal, M. K. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0038-7 · Cited by 83 · see citing works
Zhang, W.-J., Liu, H.-O., Liu, W.-S., Liu, Y., & Xu, J.-Q. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.142 · Cited by 78 · see citing works
The Roles of MicroRNAs in Stroke: Possible Therapeutic Targets
Xu, W., Gao, L., Zheng, J., Li, T., Shao, A., Reis, C., Chen, S., & Zhang, J. (2018) · Cell Transplantation · doi:10.1177/0963689718773361 · Cited by 83 · see citing works
Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain
Varol, D., Mildner, A., Blank, T., Shemer, A., Barashi, N., Yona, S., David, E., Boura‐Halfon, S., Segal-Hayoun, Y., Chappell‐Maor, L., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.003 · Cited by 81 · see citing works
Circulating microRNAs in patients with polycystic ovary syndrome
Ding, C., Chen, W.-Q., Zhu, Y.-T., Bo, Y., Hu, H., & Zheng, R. (2014) · Human Fertility · doi:10.3109/14647273.2014.956811 · Cited by 80 · see citing works
Multistability in Macrophage Activation Pathways and Metabolic Implications
Geiß, C., Salas, E., Guevara-Coto, J. A., Régnier‐Vigouroux, A., & Mora-Rodríguez, R. A. (2022) · Cells · doi:10.3390/cells11030404 · Cited by 76 · see citing works
Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages
Tian, Y., Yang, C., Yao, Q., Lei, Q., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B., Xiao, L., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01895 · Cited by 79 · see citing works
Bao, X., Zhang, Q., Liu, N., Zhuang, S., Li, Z., Meng, Q., Sun, H., Bai, J., Zhou, X., & Tang, L. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14577 · Cited by 77 · see citing works
Moradi‐Chaleshtori, M., Bandehpour, M., Heidari, N., Mohammadi‐Yeganeh, S., & Hashemi, S. M. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107198 · Cited by 76 · see citing works
MiRNAs and inflammatory bowel disease: An interesting new story
Moein, S., Vaghari‐Tabari, M., Qujeq, D., Majidinia, M., Nabavi, S. M., & Yousefi, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27173 · Cited by 74 · see citing works
The pathogenicity and virulence of Leishmania - interplay of virulence factors with host defenses
Gupta, A. K., Das, S., Kamran, M., Ejazi, S. A., & Ali, N. (2022) · Virulence · doi:10.1080/21505594.2022.2074130 · Cited by 74 · see citing works
Serotonin Modulation of Macrophage Polarization: Inflammation and Beyond
Casas-Engel, M. D. L., & Corbí, A. L. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_9 · Cited by 75 · see citing works
Xu, S., Hu, H.-T., Li, H. L., & Chang, S. (2019) · Cells · doi:10.3390/cells8101140 · Cited by 72 · see citing works
MicroRNA-720 suppresses M2 macrophage polarization by targeting GATA3
Zhong, Y., & Yi, C. (2016) · Bioscience Reports · doi:10.1042/bsr20160105 · Cited by 72 · see citing works
Zhang, M., Zhou, Z., Wang, J., & Li, S. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.10.004 · Cited by 73 · see citing works
TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity
Cui, H., Banerjee, S., Xie, N., Hussain, M., Jaiswal, A., Liu, H., Kulkarni, T., Antony, V. B., Liu, R.-M., Colonna, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57024-0 · Cited by 74 · see citing works
Self-citationThe Interplay of MicroRNAs in the Inflammatory Mechanisms Following Ischemic Stroke
Khoshnam, S. E., Winlow, W., & Farzaneh, M. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx036 · Cited by 69 · see citing works
Bao, X., Liu, X., Liu, N., Zhuang, S., Yang, Q., Ren, H., Zhao, D., Bai, J., Zhou, X., & Tang, L. (2021) · Respiratory Research · doi:10.1186/s12931-021-01785-x · Cited by 68 · see citing works
Chi, J.-Y., Hsiao, Y., Li, C., Lo, Y.-C., Lin, Z., Hong, J., Liu, Y.-M., Han, X., Wang, S., Chen, B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4364 · Cited by 68 · see citing works
Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins
McCormick, S. M., & Heller, N. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00549 · Cited by 67 · see citing works
Zhu, X., Liu, H., Zhang, Z., Wei, R., Zhou, X., Wang, Z., Zhao, L., Guo, Q., Zhang, Y., Chu, C., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.46144 · Cited by 66 · see citing works
Kink, J. A., Bellio, M. A., Forsberg, M. H., Lobo, A. K., Thickens, A. S., Lewis, B. M., Ong, I. M., Khan, A., Capitini, C. M., & Hematti, P. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03688-2 · Cited by 65 · see citing works
The role of macrophages in fibrosis of chronic kidney disease
Li, G., Yang, H., Zhang, D., Zhang, Y., Liu, B., Wang, Y.-X., Zhou, H., Xu, Z.-X., & Wang, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117079 · Cited by 67 · see citing works
Lv, J., Zeng, Y., Yu, Q., Dong, J., Zhang, Z., & Zhang, J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.01.032 · Cited by 64 · see citing works
Ma, F., Sun, P., Zhang, X., Hamblin, M. H., & Yin, K. (2020) · Science Signaling · doi:10.1126/scisignal.aay5686 · Cited by 61 · see citing works
MicroRNA regulation of macrophages in human pathologies
Wei, Y., & Schober, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2254-6 · Cited by 63 · see citing works
- Authors
- Banerjee, S., Xie, N., Cui, H., Tan, Z., Yang, S., Icyuz, M., Abraham, E., & Liu, G.
- Affiliations
- University of Alabama at Birmingham (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Banerjee, Sami
- Xie, Na
- Cui, Huachun
- Tan, Zheng
- Yang, Shanzhong
- Icyuz, Mert
- Liu, Gang
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-06
- Volume
- 190
- Issue
- 12
- Pages
- 6542-6549
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3679284
- OpenAlex
- W1927296860
- Cited by
- 320
- References
- 62
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 24 · 2023: 20 · 2022: 28 · 2021: 33 · 2020: 26 · 2019: 26 · 2018: 31 · 2017: 22 · 2016: 21 · 2015: 29 · 2014: 17 · 2013: 7 · 2012: 1
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 076206, R21HL097218, HL-105473, R01HL105473, R01HL076206, HL-097218)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR048311)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- let-7c microRNA, macrophage polarization, M1/M2 macrophages, C/EBPδ, alveolar macrophages, pulmonary fibrosis, lipopolysaccharide, phagocytosis, bactericidal activity, bone marrow-derived macrophages
- MeSH terms
- Animals, Cell Differentiation, Flow Cytometry, Macrophages, Mice, Inbred BALB C, Mice, Inbred C57BL, Phenotype, Transfection, Blotting, Western, Cell Polarity, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Real-Time Polymerase Chain Reaction
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