Streptococcus pneumoniae Endopeptidase O Promotes the Clearance of Staphylococcus aureus and Streptococcus pneumoniae via SH2 Domain-Containing Inositol Phosphatase 1-Mediated Complement Receptor 3 Upregulation

Duodenal Infusion of Donor Feces for Recurrent <i>Clostridium difficile</i>

van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Buffie, C. G., Bucci, V., Stein, R. R., McKenney, P. T., Ling, L., Gobourne, A., No, D., Liu, H., Kinnebrew, M., Viale, A., et al. (2015) · Nature · doi:10.1038/nature13828 · Cited by 1,872 · see citing works

Microbiota-mediated colonization resistance against intestinal pathogens

Buffie, C. G., & Pamer, E. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3535 · Cited by 1,564 · see citing works

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

Ng, K. M., Ferreyra, J. A., Higginbottom, S. K., Lynch, J. B., Kashyap, P. C., Gopinath, S., Naidu, N., Choudhury, B., Weimer, B. C., Monack, D. M., et al. (2013) · Nature · doi:10.1038/nature12503 · Cited by 1,035 · see citing works

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

Theriot, C. M., Koenigsknecht, M. J., Carlson, P. E., Hatton, G. E., Nelson, A. M., Li, B., Huffnagle, G. B., Z. Li, J., & Young, V. B. (2014) · Nature Communications · doi:10.1038/ncomms4114 · Cited by 974 · see citing works

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

Langdon, A. E., Crook, N., & Dantas, G. A. (2016) · Genome Medicine · doi:10.1186/s13073-016-0294-z · Cited by 917 · see citing works

The microbial metabolite desaminotyrosine protects from influenza through type I interferon

Steed, A. L., Christophi, G. P., Kaiko, G. E., Sun, L., Goodwin, V. M., Jain, U., Esaulova, E., Artyomov, M. N., Morales, D. J., Holtzman, M. J., et al. (2017) · Science · doi:10.1126/science.aam5336 · Cited by 569 · see citing works

Anticancer effects of the microbiome and its products

Zitvogel, L., Daillère, R., Roberti, M. P., Routy, B., & Kroemer, G. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.44 · Cited by 538 · see citing works

A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection

Jacobson, A., Lam, L., Rajendram, M., Tamburini, F., Honeycutt, J., Pham, T., Van Treuren, W., Pruss, K., Stabler, S. R., Lugo, K., et al. (2018) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2018.07.002 · Cited by 507 · see citing works

Pulmonary macrophages: key players in the innate defence of the airways

Byrne, A. J., Mathie, S. A., Gregory, L. G., & Lloyd, C. M. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207020 · Cited by 484 · see citing works

Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization

Ubeda, C., Bucci, V., Caballero, S., Djukovic, A., Toussaint, N. C., Equinda, M., Lipuma, L., Ling, L., Gobourne, A., No, D., et al. (2013) · Infection and Immunity · doi:10.1128/iai.01197-12 · Cited by 466 · see citing works

Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens

Pamer, E. G. (2016) · Science · doi:10.1126/science.aad9382 · Cited by 423 · see citing works

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

Lo, S. W., Gladstone, R. A., van Tonder, A. J., Lees, J. A., du Plessis, M., Benisty, R., Givon‐Lavi, N., Hawkins, P. A., Cornick, J., Kwambana-Adams, B., et al. (2019) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(19)30297-x · Cited by 293 · see citing works

Antibiotic-Induced Alterations of the Murine Gut Microbiota and Subsequent Effects on Colonization Resistance against Clostridium difficile

Schubert, A. M., Sinani, H., & Schloss, P. D. (2015) · mBio · doi:10.1128/mbio.00974-15 · Cited by 269 · see citing works

Antibiotic therapy in neonates and impact on gut microbiota and antibiotic resistance development: a systematic review

Fjalstad, J. W., Esaiassen, E., Juvet, L. K., van den Anker, J. N., & Klingenberg, C. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx426 · Cited by 175 · see citing works

Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa

Lovewell, R. R., Patankar, Y. R., & Berwin, B. L. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00335.2013 · Cited by 166 · see citing works

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

Ong, C. J., Ming‐Lum, A., Nodwell, M., Ghanipour, A., Yang, L., Williams, D. E., Kim, J., Demirjian, L., Qasimi, P., Rüschmann, J., et al. (2007) · Blood · doi:10.1182/blood-2007-03-079699 · Cited by 161 · see citing works

A Regulatory Role for Src Homology 2 Domain–Containing Inositol 5′-Phosphatase (Ship) in Phagocytosis Mediated by Fcγ Receptors and Complement Receptor 3 (α<b>M</b>β<b>2</b>; Cd11b/Cd18)

Cox, D., Dale, B. M., Kashiwada, M., Helgason, C. D., & Greenberg, S. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.1.61 · Cited by 158 · see citing works

MiR-155 Induction by F. novicida but Not the Virulent F. tularensis Results in SHIP Down-Regulation and Enhanced Pro-Inflammatory Cytokine Response

Cremer, T. J., Ravneberg, D. H., Clay, C. D., Piper-Hunter, M. G., Marsh, C. B., Elton, T. S., Gunn, J. S., Amer, A. O., Kanneganti, T., Schlesinger, L. S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008508 · Cited by 157 · see citing works

Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target

Pauls, S. D., & Marshall, A. J. (2017) · European Journal of Immunology · doi:10.1002/eji.201646795 · Cited by 118 · see citing works

Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae

Caballero, S., Carter, R. A., Ke, X., Sušac, B., Leiner, I. M., Kim, G. J., Miller, L., Ling, L., Katia, M., & Pamer, E. G. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005132 · Cited by 116 · see citing works

Donor feces infusion for eradication of Extended Spectrum beta-Lactamase producing Escherichia coli in a patient with end stage renal disease

Singh, R., van Nood, E., Nieuwdorp, M., Dam, B., ten Berge, I. J. M., Geerlings, S. E., & Bemelman, F. J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12683 · Cited by 111 · see citing works

Therapeutic Potential of SH2 Domain-Containing Inositol-5′-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer

Fuhler, G. M., Brooks, R., Toms, B., Iyer, S., Gengo, E. A., Park, M.-Y., Gumbleton, M., Viernes, D. R., Chisholm, J. D., & Kerr, W. G. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00178 · Cited by 109 · see citing works

Streptococcus pneumoniae Endopeptidase O (PepO) Is a Multifunctional Plasminogen- and Fibronectin-binding Protein, Facilitating Evasion of Innate Immunity and Invasion of Host Cells

Agarwal, V., Kuchipudi, A., Fulde, M., Riesbeck, K., Bergmann, S., & Blom, A. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.405530 · Cited by 105 · see citing works

Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease

Thiemann, S., Smit, N., Roy, U., Lesker, T. R., Gálvez, E. J. C., Koblitz, J., Basic, M., Bleich, A., Goodman, A. L., Kalinke, U., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.05.005 · Cited by 93 · see citing works

Loss of Vancomycin-Resistant Enterococcus Fecal Dominance in an Organ Transplant Patient With Clostridium difficile Colitis After Fecal Microbiota Transplant

Stripling, J. T., Kumar, R., Baddley, J. W., Nellore, A., Dixon, P. B., Howard, D., Ptacek, T., Lefkowitz, E. J., Tallaj, J. A., Benjamin, W. H., et al. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv078 · Cited by 89 · see citing works

Enlisting commensal microbes to resist antibiotic-resistant pathogens

Keith, J. W., & Pamer, E. G. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180399 · Cited by 87 · see citing works

Carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Indonesian children: A cross-sectional study

Dunne, E. M., Murad, C., Sudigdoadi, S., Fadlyana, E., Tarigan, R., Indriyani, S. A. K., Pell, C. L., Watts, E., Satzke, C., Hinds, J., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195098 · Cited by 84 · see citing works

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

Webster, S. J., Brode, S., Ellis, L., Fitzmaurice, T. J., Elder, M. J., Gekara, N. O., Tourlomousis, P., Bryant, C. E., Clare, S., Chee, R., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006383 · Cited by 81 · see citing works

Corrigendum: Bacteroides fragilis Prevents Clostridium difficile Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation

Deng, H., Yang, S., Zhang, Y., Qian, K., Zhang, Z., Liu, Y., Wang, Y., Bai, Y., Fan, H., Zhao, X., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00601 · Cited by 79 · see citing works

Binding of Streptococcus pneumoniae Endopeptidase O (PepO) to Complement Component C1q Modulates the Complement Attack and Promotes Host Cell Adherence

Agarwal, V., Sroka, M., Fulde, M., Bergmann, S., Riesbeck, K., & Blom, A. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.530212 · Cited by 73 · see citing works

Small Interfering RNA against Transcription Factor STAT6 Inhibits Allergic Airway Inflammation and Hyperreactivity in Mice

Darcan, Y., Meinicke, H., Fels, G., Hegend, O., Haberland, A., Kühl, A. A., Loddenkemper, C., Witzenrath, M., Kube, S., Henke, W., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0713433 · Cited by 71 · see citing works

Nasal absorption and biodistribution of plasmid DNA: an alternative route of DNA vaccine delivery

Oh, Y., Kim, J., Hwang, T. S., Ko, J. J., Kim, J. M., Yang, J.-S., & Kim, C. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00188-8 · Cited by 69 · see citing works

Alveolar macrophages support interferon gamma-mediated viral clearance in RSV-infected neonatal mice

Eichinger, K. M., Egaña, L. A., Orend, J. G., Resetar, E., Anderson, K. B., Patel, R. A., & Empey, K. M. (2015) · Respiratory Research · doi:10.1186/s12931-015-0282-7 · Cited by 69 · see citing works

Characteristics of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus isolated from the nasopharynx of healthy children attending day-care centres in the Czech Republic

Žemličková, H., Urbášková, P., Adámková, V., Motlová, J., Lebedova, V., & Procházka, B. (2006) · Epidemiology and Infection · doi:10.1017/s0950268806006157 · Cited by 54 · see citing works

Designing string-of-beads vaccines with optimal spacers

Schubert, B., & Kohlbacher, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0263-6 · Cited by 52 · see citing works

Sensing of Interleukin-1 Cytokines during Streptococcus pneumoniae Colonization Contributes to Macrophage Recruitment and Bacterial Clearance

Lemon, J. K., Miller, M. R., & Weiser, J. N. (2015) · Infection and Immunity · doi:10.1128/iai.00224-15 · Cited by 50 · see citing works

Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways

Zhang, H., Kang, L., Yao, H. C., He, Y., Wang, X., Xu, W., Song, Z., Yin, Y., & Zhang, X. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00023 · Cited by 45 · see citing works

Regulation of FcγR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3–mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup

Horan, K. A., Watanabe, K.-I., Kong, A. M., Bailey, C. G., Rasko, J. E. J., Sasaki, T., & Mitchell, C. A. (2007) · Blood · doi:10.1182/blood-2007-02-073874 · Cited by 45 · see citing works

Microbiota-Based Therapies for Clostridium difficile and Antibiotic-Resistant Enteric Infections

Lewis, B. B., & Pamer, E. G. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090816-093549 · Cited by 43 · see citing works

Role of SHIP1 in cancer and mucosal inflammation

Fernandes, S. R. M., Iyer, S., & Kerr, W. G. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12038 · Cited by 41 · see citing works

Streptococcus pneumoniae PepO promotes host anti-infection defense via autophagy in a Toll-like receptor 2/4 dependent manner

Shu, Z., Yuan, J., Wang, H., Zhang, J., Li, S., Zhang, H., Liu, Y., Yin, Y., & Zhang, X. (2020) · Virulence · doi:10.1080/21505594.2020.1739411 · Cited by 25 · see citing works

Burden of bacterial upper respiratory tract pathogens in school children of Nepal

Thapa, S., Gokhale, S., Sharma, A. L., Sapkota, L. B., Ansari, S., Gautam, R., Shrestha, S., & Neopane, P. (2017) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2017-000203 · Cited by 25 · see citing works

Purified Streptococcus pneumoniae Endopeptidase O (PepO) Enhances Particle Uptake by Macrophages in a Toll-Like Receptor 2- and miR-155-Dependent Manner

Yao, H., Zhang, H., Lan, K., Wang, H., Su, Y., Li, D., Song, Z., Cui, F., Yin, Y., & Zhang, X. (2017) · Infection and Immunity · doi:10.1128/iai.01012-16 · Cited by 22 · see citing works

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Terzioglu, G., & Young-Pearse, T. L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00674-9 · Cited by 95 · see citing works

The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges

Zhang, F., Zhou, Y., & Ding, J. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00368-y · Cited by 30 · see citing works

Emerging cellular and molecular interactions between the lung microbiota and lung diseases

Li, X., & Meng, X. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1992345 · Cited by 11 · see citing works

A decade of research effort in synthesis, biological activity assessments, and mechanistic investigations of sulfamethazine‐incorporating molecules

Abulkhair, H. S., & El‐Adl, K. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.202500033 · Cited by 9 · see citing works

Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk

Gelemanović, A., Ardalić, T. Ć., Pribisalić, A., Hayward, C., Kolčić, I., & Polašek, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087006 · Cited by 4 · see citing works

Advances in the Mechanism of Streptococcus Pneumoniae Surface Proteins Evading the Immune Response Mediated by the Complement System

万, 学. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1541169

Neprilysin homolog of streptococci

Meyer, D. H., Oetjen, J., & Fives-Taylor, P. M. (2025) · Handbook of Proteolytic Enzymes · doi:10.1016/b978-0-443-28849-4.00065-5

The SHIP1-inflammatory-lipid axis in Alzheimer’s disease: from genetic risk to spatiotemporal mechanistic insights

Xi, R., Zheng, X., Zhao, J., & Fu, Y. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03819-x · Cited by 1 · see citing works

Purified Streptococcus pneumoniae Endopeptidase O (PepO) Enhances Particle Uptake by Macrophages in a Toll-Like Receptor 2- and miR-155-Dependent Manner

Yao, H., Zhang, H., Lan, K., Wang, H., Su, Y., Li, D., Song, Z., Cui, F., Yin, Y., & Zhang, X. (2017) · Infection and Immunity · doi:10.1128/iai.01012-16 · Cited by 22 · see citing works

Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways

Zhang, H., Kang, L., Yao, H. C., He, Y., Wang, X., Xu, W., Song, Z., Yin, Y., & Zhang, X. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00023 · Cited by 45 · see citing works

Streptococcus pneumoniae Endopeptidase O (PepO) Is a Multifunctional Plasminogen- and Fibronectin-binding Protein, Facilitating Evasion of Innate Immunity and Invasion of Host Cells

Agarwal, V., Kuchipudi, A., Fulde, M., Riesbeck, K., Bergmann, S., & Blom, A. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.405530 · Cited by 105 · see citing works

Streptococcus pneumoniae PepO promotes host anti-infection defense via autophagy in a Toll-like receptor 2/4 dependent manner

Shu, Z., Yuan, J., Wang, H., Zhang, J., Li, S., Zhang, H., Liu, Y., Yin, Y., & Zhang, X. (2020) · Virulence · doi:10.1080/21505594.2020.1739411 · Cited by 25 · see citing works

sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae

Li, H., Bradbury, J. A., Edin, M. L., Graves, J. P., Gruzdev, A., Cheng, J., Hoopes, S. L., DeGraff, L. M., Fessler, M. B., Garantziotis, S., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci129679 · Cited by 31 · see citing works