A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection
Open accessAbstract
The intestinal microbiota provides colonization resistance against pathogens, limiting pathogen expansion and transmission. These microbiota-mediated mechanisms were previously identified by observing loss of colonization resistance after antibiotic treatment or dietary changes, which severely disrupt microbiota communities. We identify a microbiota-mediated mechanism of colonization resistance against Salmonella enterica serovar Typhimurium (S. Typhimurium) by comparing high-complexity commensal communities with different levels of colonization resistance. Using inbred mouse strains with different infection dynamics and S. Typhimurium intestinal burdens, we demonstrate that Bacteroides species mediate colonization resistance against S. Typhimurium by producing the short-chain fatty acid propionate. Propionate directly inhibits pathogen growth in vitro by disrupting intracellular pH homeostasis, and chemically increasing intestinal propionate levels protects mice from S. Typhimurium. In addition, administering susceptible mice Bacteroides, but not a propionate-production mutant, confers resistance to S. Typhimurium. This work provides mechanistic understanding into the role of individualized microbial communities in host-to-host variability of pathogen transmission.
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Propionate produced by Bacteroides thetaiotaomicron negatively impacted the growth of Salmonella enterica serovar Typhimurium.
“Propionate produced by Bacteroides thetaiotaomicron negatively impacted the growth of Salmonella enterica serovar Typhimurium [40].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [40]
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- Authors
- Jacobson, A., Lam, L., Rajendram, M., Tamburini, F., Honeycutt, J., Pham, T., Van Treuren, W., Pruss, K., Stabler, S. R., Lugo, K., Bouley, D. M., Vilches-Moure, J. G., Smith, M., Sonnenburg, J. L., Bhatt, A. S., Huang, K. C., & Monack, D.
- Affiliations
- Stanford University (US)
- Chan Zuckerberg Biohub San Francisco (US)
- Stanford Medicine (US)
- Corresponding author
- Monack, Denise
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 24
- Issue
- 2
- Pages
- 296-307.e7
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC6223613
- OpenAlex
- W2884218973
- Cited by
- 507
- References
- 68
- Citations by year
- 2026: 43 · 2025: 69 · 2024: 59 · 2023: 68 · 2022: 81 · 2021: 78 · 2020: 65 · 2019: 37 · 2018: 6
- FWCI
- 16.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01-DK085025)
- National Science Foundation (T32GM007276, MCB-1149328)
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of General Medical Sciences (F32AI133917)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- colonization resistance, Salmonella typhimurium, gut microbiota, Bacteroides, propionate, short-chain fatty acids, intracellular pH homeostasis, inbred mouse strains, pathogen growth inhibition
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Natural Resistance-associated Macrophage Protein 1, Animals, Bacteroides, Fatty Acids, Volatile, Feces, Female, Intestinal Diseases, Male, Mice, Inbred C57BL, Propionates, Salmonella Infections, Salmonella typhimurium, Cation Transport Proteins, Host-Pathogen Interactions, Bacterial Shedding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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