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Gut Microbiota and Diarrhea: An Updated Review
Open accessAbstract
Diarrhea is a common problem to the whole world and the occurrence of diarrhea is highly associated with gut microbiota, such as bacteria, fungi, and viruses. Generally, diarrheal patients or animals are characterized by gut microbiota dysbiosis and pathogen infections may lead to diarrheal phenotypes. Of relevance, reprograming gut microbiota communities by dietary probiotics or fecal bacteria transplantation are widely introduced to treat or prevent diarrhea. In this review, we discussed the influence of the gut microbiota in the infection of diarrhea pathogens, and updated the research of reshaping the gut microbiota to prevent or treat diarrhea for the past few years. Together, gut microbiota manipulation is of great significance to the prevention and treatment of diarrhea, and further insight into the function of the gut microbiota will help to discover more anti-diarrhea probiotics.
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“They help treat acute diarrhea by restoring gut flora, strengthening mucosal barriers, and modulating immunity.1,4”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [1]
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Metadata
- Authors
- Li, Y., Xia, S., Jiang, X., Feng, C., Gong, S., Ma, J., Fang, Z., Yin, J., & Yin, Y.
- Affiliations
- Hunan Agricultural University (CN)
- Sichuan Agricultural University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Fang, Zhengfeng
- Yin, Jie
- ORCID
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2021-04-15
- Volume
- 11
- Pages
- 625210-625210
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC8082445
- OpenAlex
- W3154804190
- Cited by
- 219
- References
- 106
- Citations by year
- 2026: 29 · 2025: 49 · 2024: 57 · 2023: 49 · 2022: 27 · 2021: 8
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Chinese Academy of Sciences (QYZDY-SSWSMC008, 2021QNRC001)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, diarrhea, dysbiosis, probiotics, fecal microbiota transplantation, pathogen infection, dietary intervention, microbiome manipulation
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Diarrhea, Humans, Probiotics, Dysbiosis
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