Cited by 219Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

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Gut Microbiota and Diarrhea: An Updated Review

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Li, Yunxia, Xia, Siting, Jiang, Xiaohan, Feng, Can, Gong, Saiming, Ma, Jie, Fang, Zhengfeng, Yin, Jie, Yin, Yulong·2021·Frontiers in Cellular and Infection Microbiology

DOI 10.3389/fcimb.2021.625210PMC PMC8082445

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Abstract

Diarrhea is a common problem to the whole world and the occurrence of diarrhea is highly associated with gut microbiota, such as bacteria, fungi, and viruses. Generally, diarrheal patients or animals are characterized by gut microbiota dysbiosis and pathogen infections may lead to diarrheal phenotypes. Of relevance, reprograming gut microbiota communities by dietary probiotics or fecal bacteria transplantation are widely introduced to treat or prevent diarrhea. In this review, we discussed the influence of the gut microbiota in the infection of diarrhea pathogens, and updated the research of reshaping the gut microbiota to prevent or treat diarrhea for the past few years. Together, gut microbiota manipulation is of great significance to the prevention and treatment of diarrhea, and further insight into the function of the gut microbiota will help to discover more anti-diarrhea probiotics.

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Microbiota medicine: towards clinical revolution
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Authors: Li, Y., Xia, S., Jiang, X., Feng, C., Gong, S., Ma, J., Fang, Z., Yin, J., & Yin, Y.
Affiliations: Hunan Agricultural University (CN)
Sichuan Agricultural University (CN)
Chinese Academy of Sciences (CN)
Corresponding author: Fang, Zhengfeng
Yin, Jie
ORCID: Li, Yunxia
Xia, Siting
Jiang, Xiaohan
Feng, Can
Gong, Saiming
Ma, Jie
Fang, Zhengfeng
Yin, Jie
Yin, Yulong
Venue: Frontiers in Cellular and Infection Microbiology
Publisher: Frontiers Media SA
Published: 2021-04-15
Volume: 11
Pages: 625210-625210
ISSN: 2235-2988 (ISSN-L)
DOI: 10.3389/fcimb.2021.625210
PMC: PMC8082445
OpenAlex: W3154804190
Cited by: 219
References: 106
Citations by year: 2026: 29 · 2025: 49 · 2024: 57 · 2023: 49 · 2022: 27 · 2021: 8
FWCI: 3.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Chinese Academy of Sciences (QYZDY-SSWSMC008, 2021QNRC001)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, diarrhea, dysbiosis, probiotics, fecal microbiota transplantation, pathogen infection, dietary intervention, microbiome manipulation
MeSH terms: Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Diarrhea, Humans, Probiotics, Dysbiosis

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