The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy
Open accessAbstract
As a complex multicellular structure of the vascular system at the central nervous system (CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and regulates the influx and efflux of substances to maintain the steady-state environment of the CNS. Lipopolysaccharide (LPS), the cell wall component of Gram-negative bacteria, can damage the barrier function of BBB and further promote the occurrence and development of sepsis-associated encephalopathy (SAE). Here, we conduct a literature review of the direct and indirect damage mechanisms of LPS to BBB and the relationship between these processes and SAE. We believe that after LPS destroys BBB, a large number of inflammatory factors and neurotoxins will enter and damage the brain tissue, which will activate brain immune cells to mediate inflammatory response and in turn further destroys BBB. This vicious circle will ultimately lead to the progression of SAE. Finally, we present a succinct overview of the treatment of SAE by restoring the BBB barrier function and summarize novel opportunities in controlling the progression of SAE by targeting the BBB.
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Cites
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Pericytes regulate the blood–brain barrier
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Blood-Brain Barrier: From Physiology to Disease and Back
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Cited by
Skrzypczak-Wiercioch, A., & Sałat, K. (2022) · Molecules · doi:10.3390/molecules27175481 · Cited by 406
Wang, X., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2023) · Microbiome · doi:10.1186/s40168-022-01452-3 · Cited by 273
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown
Wei, C., Jiang, W., Wang, R., Zhong, H., He, H., Gao, X., Zhong, S., Yu, F., Guo, Q., Zhang, L., et al. (2024) · Nature · doi:10.1038/s41586-024-07314-2 · Cited by 268
Self-citationTRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
Huang, X., Ye, C., Zhao, X., Tong, Y., Lin, W., Huang, Q., Zheng, Y., Wang, J., Zhang, A., & Mo, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02959-8 · Cited by 60
Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
Wang, X., Wen, X., Yuan, S., & Zhang, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106499 · Cited by 47
Metadata
- Authors
- Peng, X., Luo, Z., He, S., Zhang, L., & Li, Y.
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2021-11-04
- Volume
- 11
- Pages
- 768108-768108
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W3208070222
- Cited by
- 267
- References
- 226
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- gold
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- Peng, X., Luo, Z., He, S., Zhang, L., & Li, Y. (2021). Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encephalopathy. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2021.768108
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
