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Cited by 46Endodontics and Root Canal TreatmentsPeriodontal Regeneration and TreatmentsDental materials and restorations

Deciphering Reparative Processes in the Inflamed Dental Pulp

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El karim, Ikhlas A., Cooper, Paul R., About, Imad, Tomson, Phillip L., Lundy, Fionnuala T., Duncan, Henry F.·2021·Frontiers in Dental Medicine
DOI 10.3389/fdmed.2021.651219
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Abstract

Research over several decades has increased our understanding of the nature of reparative and regenerative processes in the dental pulp, at both the cellular and molecular level. However, advances in scientific knowledge have not translated into novel clinical treatment strategies for caries-induced pulpitis. This narrative review explores the evidence regarding the ability of inflamed pulp tissue to heal and how this knowledge may be used therapeutically. A literature search and evidence analysis covering basic, translational and clinical pulp biology research was performed. The review focuses on (1) the regenerative and defense capabilities of the pulp during caries-induced inflammation; (2) the potential of novel biomaterials to harness the reparative and regenerative functions of the inflamed pulp; and (3) future perspectives and opportunities for conservative management of the inflamed pulp. Current conservative management strategies for pulpitis are limited by a combination of unreliable diagnostic tools and an outdated understanding of pulpal pathophysiological responses. This approach leads to the often unnecessary removal of the entire pulp. Consequently, there is a need for better diagnostic approaches and a focus on minimally-invasive treatments utilizing biologically-based regenerative materials and technologies.

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  • Current research recognizes pulp's healing capacity and defensive mechanisms, which have shifted treatment paradigms for both primary and permanent dentitions.

    “Current research recognizes pulp's healing capacity and defensive mechanisms, which have shifted treatment paradigms for both primary and permanent dentitions [1, 2].”

    From Consensus‐Based Recommendations on Pulp Therapies in Primary and Permanent Teeth: <scp>IAPD</scp> Porto Forum (2026) · cites this paper as [1]

    The Introduction describes the pulp’s defensive properties and healing potential and promotes minimally invasive vital pulp treatment. The Conclusion supports a role for such treatment in permanent teeth, but the paper does not establish a treatment-paradigm shift for both primary and permanent dentitions; its Abstract says scientific advances have not yet translated into novel clinical treatment strategies for caries-induced pulpitis. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Authors
El karim, I. A., Cooper, P. R., About, I., Tomson, P. L., Lundy, F. T., & Duncan, H. F.
Affiliations
  • University of Otago (NZ)
  • Centre National de la Recherche Scientifique (FR)
  • University of Birmingham (GB)
  • Queen's University Belfast (GB)
  • Trinity College Dublin (IE)
ORCID
Venue
Frontiers in Dental Medicine
Publisher
Frontiers Media SA
Published
2021-03-31
Volume
2
ISSN
2673-4915 (ISSN-L)
DOI
10.3389/fdmed.2021.651219
OpenAlex
W3143106456
Cited by
46
References
4
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2026: 15 · 2025: 13 · 2024: 9 · 2023: 5 · 2022: 3 · 2021: 1
FWCI
4.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Dental Medicine (publishedVersion, cc-by)
  • Research Portal (Queen's University Belfast) (acceptedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
Keywords
dental pulp, pulpitis, dental pulp regeneration, reparative processes, biomaterials, minimally invasive treatment, pulp diagnosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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