The two NF-κB activation pathways and their role in innate and adaptive immunity
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NF-κB is an important inducible transcription factor playing a key role in immune and inflammatory responses, cellular adhesion, differentiation, proliferation, and apoptosis.
“The nuclear factor-κB (NF-κB) is an important inducible transcription factor playing a key role in processes of the immune and inflammatory responses, cellular adhesion, differentiation, proliferation, and apoptosis (Bonizzi and Karin 2004).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Bonizzi and Karin 2004
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- Authors
- Bonizzi, G., & Karin, M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Bonizzi, Giuseppina
- ORCID
- Karin, Michael
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 25
- Issue
- 6
- Pages
- 280-288
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2074150439
- Cited by
- 2,535
- References
- 69
- Citations by year
- 2026: 37 · 2025: 58 · 2024: 57 · 2023: 85 · 2022: 85 · 2021: 98 · 2020: 109 · 2019: 107 · 2018: 104 · 2017: 118 · 2016: 111 · 2015: 142 · 2014: 130 · 2013: 147 · 2012: 141
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- National Institutes of Health
- U.S. Public Health Service (DJ 35108)
- National Institute of Allergy and Infectious Diseases (AI 43477)
- National Institute of Environmental Health Sciences (P42ES010337, ES10337, ES 06376, R01ES006376)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB, NF-κB signaling, classical pathway, alternative pathway, innate immunity, adaptive immunity, TNF-α, interleukin-1, pathogen-associated molecular patterns, inflammatory cytokines, Rel family transcription factors, inflammation
- MeSH terms
- Adaptation, Physiological, Animals, Immunity, Innate, Lymphoid Tissue, Signal Transduction, Cytokines, NF-kappa B, Protein Serine-Threonine Kinases, Models, Immunological, Mice, I-kappa B Kinase
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