Cited by 2,535NF-κB Signaling PathwaysImmune Response and InflammationSignaling Pathways in Disease

The two NF-κB activation pathways and their role in innate and adaptive immunity

Bonizzi, Giuseppina, Karin, Michael·2004·Trends in Immunology

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Registry

Crossref · 10.1016/j.it.2004.03.008

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69 of 69 references verified0 citation errors · 0 not checkable

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  • NF-κB is an important inducible transcription factor playing a key role in immune and inflammatory responses, cellular adhesion, differentiation, proliferation, and apoptosis.

    “The nuclear factor-κB (NF-κB) is an important inducible transcription factor playing a key role in processes of the immune and inflammatory responses, cellular adhesion, differentiation, proliferation, and apoptosis (Bonizzi and Karin 2004).”

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Authors
Bonizzi, G., & Karin, M.
Affiliations
University of California San Diego (US)
Corresponding author
Bonizzi, Giuseppina
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2004-06
Volume
25
Issue
6
Pages
280-288
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2074150439
Cited by
2,535
References
69
Citations by year
2026: 37 · 2025: 58 · 2024: 57 · 2023: 85 · 2022: 85 · 2021: 98 · 2020: 109 · 2019: 107 · 2018: 104 · 2017: 118 · 2016: 111 · 2015: 142 · 2014: 130 · 2013: 147 · 2012: 141
FWCI
9.45
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Cancer Society
  • National Institutes of Health
  • U.S. Public Health Service (DJ 35108)
  • National Institute of Allergy and Infectious Diseases (AI 43477)
  • National Institute of Environmental Health Sciences (P42ES010337, ES10337, ES 06376, R01ES006376)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
NF-κB, NF-κB signaling, classical pathway, alternative pathway, innate immunity, adaptive immunity, TNF-α, interleukin-1, pathogen-associated molecular patterns, inflammatory cytokines, Rel family transcription factors, inflammation
MeSH terms
Adaptation, Physiological, Animals, Immunity, Innate, Lymphoid Tissue, Signal Transduction, Cytokines, NF-kappa B, Protein Serine-Threonine Kinases, Models, Immunological, Mice, I-kappa B Kinase

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