Neurosteroid influences on sensitivity to ethanol

Helms, Christa M.; Rossi, David J.; Grant, Kathleen A.

doi:10.3389/fendo.2012.00010

Cited by 30Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

Neurosteroid influences on sensitivity to ethanol

Open access

Helms, Christa M., Rossi, David J., Grant, Kathleen A.·2012·Frontiers in Endocrinology

DOI 10.3389/fendo.2012.00010PMC PMC3356014

Open this paper in CoChat — free account Open PDF

Abstract

Harrison and Simmonds (1984) provided the first clear evidence that neuroactive steroids act at specific neurotransmitter receptors, investigating the potentiation of muscimol-induced GABAA responses by alphaxalone (3α-hydroxy 5α -pregnane l l,20-dione) in cortical slices. Within 2 years, a progesterone metabolite (3α-hydroxy-5α-pregnan-20-one, 3α,5α-THP, allopregnanolone) and a deoxycorticosterone metabolite (3α,21-dihydroxy-5α-pregnan-20-one, 3α,5α-THDOC, tetrahydrodeoxycorticosterone, THDOC) were shown to be positive modulators of GABAA receptors (Majewska et al., 1986). That same year, publications showed that ethanol has direct action at GABAA receptors (Allan and Harris, 1986, Suzdak et al., 1986). Thus, the GABAA receptor complex was identified as a membrane-bound target providing a pharmacological basis for shared sensitivity between neurosteroids and ethanol. The common behavioral effects of ethanol and neuroactive steroids were compared directly using drug discrimination procedures (Ator et al., 1993). The N-methyl-D-aspartate (NMDA) receptor complex, a membrane-bound ionophore important for excitatory glutamate neurotransmission, was shown to be antagonized by low concentrations of ethanol (Lovinger et al., 1989). Since data were emerging for neurosteroid activity at NMDA receptors (Wu et al., 1991), the stage was set for the suggestion that neurosteroids, and physiological states that alter circulating neuroactive steroids, could affect sensitivity to alcohol (Grant et al., 1997). The unique interface of ethanol and neurosteroids encompasses molecular, cellular, physiological and behavioral processes. This review will highlight a variety of mechanisms by which neurosteroids affect sensitivity to ethanol, including metabolic pathways, physiological states associated with activity of the hypothalamic-pituitary adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes, and the effects of chronic exposure to ethanol, in addition to behavioral implications.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fendo.2012.00010

Cites

224 of 224 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ethanol-induced increases in neurosteroid concentrations may underlie some behavioral effects of ethanol.
“Finally, it should be noted that in addition to directly modulating the activity of GABAARs, ethanol also increases neurosteroid concentrations, which may also underlie some of its behavioral affects (see [116] for a review).”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [116]
Ethanol increases neurosteroid concentrations.
“Finally, it should be noted that in addition to directly modulating the activity of GABAARs, ethanol also increases neurosteroid concentrations, which may also underlie some of its behavioral affects (see [116] for a review).”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [116]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., & Paul, S. M. (1986) · Science · doi:10.1126/science.2422758 · Cited by 2,225 · see citing works
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081 · see citing works
Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey
Grant, B. F., & Dawson, D. A. (1997) · Journal of Substance Abuse · doi:10.1016/s0899-3289(97)90009-2 · Cited by 1,793 · see citing works
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
Wisden, W., Laurie, D. J., Monyer, H., & Seeburg, P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01040.1992 · Cited by 1,543 · see citing works
Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,447 · see citing works
Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects
WEITZMAN, E. D., FUKUSHIMA, D., NOGEIRE, C., ROFFWARG, H., GALLAGHER, T. F., & HELLMAN, L. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-1-14 · Cited by 1,258 · see citing works
Regulation of the acute production of steroids in steroidogenic cells
STOCCO, D. M., & CLARK, B. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-3-221 · Cited by 1,057 · see citing works
Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.
Purdy, R. H., Morrow, A. L., Moore, P. H., & Paul, S. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4553 · Cited by 951 · see citing works
The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies
Goldman, J. M., Murr, A. S., & Cooper, R. L. (2007) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20106 · Cited by 804 · see citing works
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA A receptors
Stell, B. M., Brickley, S. G., Tang, C., Farrant, M., & Módy, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2435457100 · Cited by 799 · see citing works
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites
Hosie, A. M., Wilkins, M. E., da Silva, H. M. A., & Smart, T. G. (2006) · Nature · doi:10.1038/nature05324 · Cited by 752 · see citing works
Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.066 · Cited by 752 · see citing works
Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.
Brickley, S. G., Cull-Candy, S. G., & Farrant, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021806 · Cited by 717 · see citing works
Regulation of the acute production of steroids in steroidogenic cells
Stocco, D. M. (1996) · Endocrine Reviews · doi:10.1210/er.17.3.221 · Cited by 635 · see citing works
Channel-Mediated Tonic GABA Release from Glia
Lee, S.-J., Yoon, B., Berglund, K., Oh, S., Park, H., Shin, H., Augustine, G. J., & Lee, C. J. (2010) · Science · doi:10.1126/science.1184334 · Cited by 595 · see citing works
A Selective Imidazobenzodiazepine Antagonist of Ethanol in the Rat
Suzdak, P. D., Glowa, J. R., Crawley, J. N., Schwartz, R. D., Skolnick, P., & Paul, S. M. (1986) · Science · doi:10.1126/science.3022383 · Cited by 543 · see citing works
Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.
Wu, F., Gibbs, T. T., & Farb, D. H. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12923-4 · Cited by 534 · see citing works
Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
Crabb, D. W., Matsumoto, M., Chang, D., & You, M. (2004) · Proceedings of the Nutrition Society · doi:10.1079/pns2003327 · Cited by 521 · see citing works
Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice
Mihalek, R., Banerjee, P., Korpi, E. R., Quinlan, J. J., Firestone, L. L., Mi, Z.-P., Lagenaur, C. F., Tretter, V. E., Sieghart, W., Anagnostaras, S., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12905 · Cited by 520 · see citing works
Neurosteroids act on recombinant human GABAA receptors
Puia, G., Santi, M., Vicini, S., Pritchett, D. B., Purdy, R. H., Paul, S. M., Seeburg, P. H., & Costa, E. (1990) · Neuron · doi:10.1016/0896-6273(90)90202-q · Cited by 519 · see citing works
Modulation of the GABA receptor complex by a steroid anaesthetic
Harrison, N. L., & Simmonds, M. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)90299-3 · Cited by 501 · see citing works
The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progress
Kumar, S., Porcu, P., Werner, D. F., Matthews, D. B., Diaz‐Granados, J. L., Helfand, R. S., & Morrow, A. L. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1562-z · Cited by 432 · see citing works
Thalamic synchrony and dynamic regulation of global forebrain oscillations
Huguenard, J. R., & McCormick, D. A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.05.007 · Cited by 395 · see citing works
Enhanced Neurosteroid Potentiation of Ternary GABAAReceptors Containing the δ Subunit
Wohlfarth, K., Bianchi, M. T., & Macdonald, R. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01541.2002 · Cited by 393 · see citing works
Circulating Levels of Allopregnanolone in Humans: Gender, Age, and Endocrine Influences
Genazzani, A. R., Petraglia, F., Bernardi, F., Casarosa, E., Salvestroni, C., Tonetti, A., Nappi, R. E., Luisi, S. V., Palumbo, M. A., Purdy, R. H., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4905 · Cited by 392 · see citing works
The cellular, molecular and ionic basis of GABAA receptor signalling
Farrant, M., & Kaila, K. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)60005-8 · Cited by 369 · see citing works
GABAA receptor diversity and pharmacology
Möhler, H. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0284-3 · Cited by 359 · see citing works
Activation of GABAA Receptors: Views from Outside the Synaptic Cleft
Glykys, J., & Mody, I. (2007) · Neuron · doi:10.1016/j.neuron.2007.11.002 · Cited by 358 · see citing works
Sulfated and unsulfated steroids modulate γ-aminobutyric acidA receptor function through distinct sites
Park-Chung, M., Malayev, A., Purdy, R. H., Gibbs, T. T., & Farb, D. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01381-5 · Cited by 354 · see citing works
Insomnia, alcoholism and relapse
Brower, K. J. (2003) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(03)90005-0 · Cited by 354 · see citing works
Tonic and Spillover Inhibition of Granule Cells Control Information Flow through Cerebellar Cortex
Hamann, M., Rossi, D. J., & Attwell, D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00593-7 · Cited by 347 · see citing works
Self-citation
Spillover-Mediated Transmission at Inhibitory Synapses Promoted by High Affinity α6 Subunit GABAA Receptors and Glomerular Geometry
Rossi, D. J., & Hamann, M. (1998) · Neuron · doi:10.1016/s0896-6273(00)81016-8 · Cited by 340 · see citing works
Self-citation
Assembly of GABAA receptor subunits: role of the delta subunit
Saxena, N., & Macdonald, R. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-11-07077.1994 · Cited by 338 · see citing works
Defining the role of GABA in cortical development
Wang, D. D., & Kriegstein, A. R. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.167635 · Cited by 336 · see citing works
The influence of subunit composition on the interaction of neurosteroids with GABAA receptors
Belelli, D., Casula, A. M., Ling, A., & Lambert, J. J. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00172-7 · Cited by 335 · see citing works
Sleep, sleepiness, and alcohol use.
Roehrs, T., & Roth, T. (2001) · PubMed · Cited by 326 · see citing works
Astrocytes are GABAergic cells that modulate microglial activity
Lee, M., Schwab, C., & McGeer, P. L. (2010) · Glia · doi:10.1002/glia.21087 · Cited by 321 · see citing works
Social Isolation‐Induced Decreases in Both the Abundance of Neuroactive Steroids and GABAA Receptor Function in Rat Brain
Serra, M., Pisu, M. G., Littera, M., Papi, G., Sanna, E., Tuveri, F., Usala, L., Purdy, R. H., & Biggio, G. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750732.x · Cited by 315 · see citing works
Withdrawal from Chronic Intermittent Ethanol Treatment Changes Subunit Composition, Reduces Synaptic Function, and Decreases Behavioral Responses to Positive Allosteric Modulators of GABAA Receptors
Cagetti, E., Liang, J., Spigelman, I., & Olsen, R. W. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.53 · Cited by 315 · see citing works
Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
VanDoren, M. J., Matthews, D. B., Janis, G. C., Grobin, A. C., Devaud, L. L., & Morrow, A. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01982.2000 · Cited by 314 · see citing works
The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus
Patchev, V. K., Shoaib, M., Holsboer, F., & Almeida, O. F. X. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90330-1 · Cited by 306 · see citing works
Alcohol-induced motor impairment caused by increased extrasynaptic GABAA receptor activity
Hanchar, H. J., Dodson, P. D., Olsen, R. W., Otis, T. S., & Wallner, M. (2005) · Nature Neuroscience · doi:10.1038/nn1398 · Cited by 306 · see citing works
Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.
Saxena, N., & Macdonald, R. L. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08745-0 · Cited by 293 · see citing works
The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus
Patchev, V (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00096-6 · Cited by 283 · cited 4× · see citing works
“A recent report indicated that physiological concentrations of allopregnanolone, THDOC, and pregnenolone in cell culture inhibited CRH reporter gene activity and forskolin-stimulated transcription (Budziszewska et al., 2010).”
BackgroundInfluential
Gamma-aminobutyric acid and alcohol actions: Neurochemical studies of long sleep and short sleep mice
Allan, A. M., & Harris, R. A. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90324-3 · Cited by 282 · see citing works
Development of Action Potential‐dependent and Independent Spontaneous GABAA Receptor‐mediated Currents in Granule Cells of Postnatal Rat Cerebellum
Wall, M. J., & Usowicz, M. M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01630.x · Cited by 270 · see citing works
Blunted Stress Cortisol Response in Abstinent Alcoholic and Polysubstance-Abusing Men
Lovallo, W. R., Dickensheets, S. L., Myers, D. A., Thomas, T. L., & Nixon, S. J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02036.x · Cited by 266 · see citing works
Transcriptional regulation of steroidogenic genes: StARD1, CYP11A1 and HSD3B
LaVoie, H. A., & King, S. R. (2009) · Experimental Biology and Medicine · doi:10.3181/0903-mr-97 · Cited by 261 · see citing works
Multiple modes of GABAergic inhibition of rat cerebellar granule cells
Rossi, D. J., Hamann, M., & Attwell, D. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00097.x · Cited by 256 · see citing works
Self-citation
A new naturally occurring GABAA receptor subunit partnership with high sensitivity to ethanol
Glykys, J. C., Peng, Z., Chandra, D., Homanics, G. E., Houser, C. R., & Módy, I. (2006) · Nature Neuroscience · doi:10.1038/nn1813 · Cited by 254 · see citing works
The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus
Glykys, J. C., & Módy, I. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.134460 · Cited by 253 · see citing works
Follow-up Study of Anxiety Disorder and Alcohol Dependence in Comorbid Alcoholism Treatment Patients
Kushner, M. G., Abrams, K., Thuras, P., Hanson, K. L., Brekke, M., & Sletten, S. (2005) · Alcoholism: Clinical & Experimental Research · doi:10.1097/01.alc.0000175072.17623.f8 · Cited by 244 · see citing works
Low Ethanol Concentrations Selectively Augment the Tonic Inhibition Mediated by δ Subunit-Containing GABAAReceptors in Hippocampal Neurons
Wei, W., Faria, L. C., & Módy, I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2040-04.2004 · Cited by 242 · see citing works
Neurosteroid regulation of GABAA receptors: Focus on the α4 and δ subunits
Smith, S. S., Shen, H., Gong, Q. H., & Zhou, X. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.008 · Cited by 241 · see citing works
Reversal of neurosteroid effects at α4β2δ GABAA receptors triggers anxiety at puberty
Shen, H., Gong, Q. H., Aoki, C. J., Yuan, M., Ruderman, Y., Dattilo, M., Williams, K. L., & Smith, S. S. (2007) · Nature Neuroscience · doi:10.1038/nn1868 · Cited by 235 · see citing works
Alcohol Enhances GABAergic Transmission to Cerebellar Granule Cells via an Increase in Golgi Cell Excitability
Carta, M., Mameli, M., & Valenzuela, C. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0067-04.2004 · Cited by 221 · see citing works
Distinct Sites for Inverse Modulation ofN-Methyl-d-Aspartate Receptors by Sulfated Steroids
Park-Chung, M., Wu, F., Purdy, R. H., Malayev, A., Gibbs, T. T., & Farb, D. H. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.6.1113 · Cited by 220 · see citing works
Multiple modes of GABAergic inhibition of rat cerebellar granule cells
Rossi, D. J., Hamann, M., & Attwell, D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.036459 · Cited by 217 · see citing works
Self-citation
Sex Differences in Ethanol Intake and Sensitivity to Aversive Effects during Adolescence and Adulthood
Vetter-O’Hagen, C. S., Varlinskaya, E. I., & SPEAR, L. P. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agp048 · Cited by 212 · see citing works
Drinking Typography Established by Scheduled Induction Predicts Chronic Heavy Drinking in a Monkey Model of Ethanol Self‐Administration
Grant, K. A., Leng, X., Green, H. L., Szeliga, K. T., Rogers, L. S. M., & Gonzales, S. W. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00765.x · Cited by 204 · see citing works
Self-citation
Chronic ethanol administration alters gamma-aminobutyric acidA receptor gene expression.
Mhatre, M., & Ticku, M. K. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08934-5 · Cited by 203 · see citing works
Brain Steroidogenesis Mediates Ethanol Modulation of GABAAReceptor Activity in Rat Hippocampus
Sanna, E., Talani, G., Busonero, F., Pisu, M. G., Purdy, R. H., Serra, M., & Biggio, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0075-04.2004 · Cited by 202 · see citing works
Reproducibility of Serum Sex Steroid Assays in Men by RIA and Mass Spectrometry
Hsing, A. W., Stanczyk, F. Z., Bélanger, A., Schroeder, P., Chang, L., Falk, R. T., & Fears, T. R. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0792 · Cited by 190 · see citing works
Gabaergic and dopaminergic transmission in the rat cerebral cortex: Effect of stress, anxiolytic and anxiogenic drugs
Biggio, G., Concas, A., Corda, M. G., Giorgi, O., Sanna, E., & Serra, M. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90077-f · Cited by 181 · see citing works
Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal.
Devaud, L. L., Purdy, R. H., Finn, D. A., & Morrow, A. L. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20630-9 · Cited by 181 · see citing works
Conserved site for neurosteroid modulation of GABAA receptors
Hosie, A. M., Clarke, L., da Silva, H., & Smart, T. G. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.050 · Cited by 170 · see citing works
The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol
Borghese, C. M., Stórustovu, S. I., Ebert, B., Herd, M. B., Belelli, D., Lambert, J. J., Marshall, G. R., Wafford, K. A., & Harris, R. A. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.092452 · Cited by 170 · see citing works
3β-Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABAAReceptor Antagonists
Wang, M., He, Y., Eisenman, L. N., Fields, C. T., Zeng, C.-M., Mathews, J., Benz, A. M., Fu, T., Zorumski, E. C., Steinbach, J. H., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03366.2002 · Cited by 169 · see citing works
Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons
Bäckström, T., Haage, D., Löfgren, M., Johansson, I. M., Strömberg, J., Nyberg, S., Andréen, L., Ossewaarde, L., van Wingen, G. A., Turkmen, S., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.061 · Cited by 169 · see citing works
Conceptual framework for the etiology of alcoholism: a “kindling”/stress hypothesis
Breese, G. R., Overstreet, D. H., & Knapp, D. J. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2016-2 · Cited by 167 · see citing works
A Critical Role for α4βδ GABA A Receptors in Shaping Learning Deficits at Puberty in Mice
Shen, H., Sabaliauskas, N. A., Sherpa, A. D., Fenton, A. A., Stelzer, A., Aoki, C. J., & Smith, S. S. (2010) · Science · doi:10.1126/science.1184245 · Cited by 166 · see citing works
Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro
Calogero, A. E., Gallucci, W. T., Chrousos, G. P., & Gold, P. W. (1988) · Brain Research · doi:10.1016/0006-8993(88)90523-9 · Cited by 166 · see citing works
Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABAA receptors
Meera, P., Wallner, M., & Otis, T. S. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00450.2011 · Cited by 161 · see citing works
Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevance
Belelli, D., Herd, M. B., Mitchell, E. A., Peden, D. R., Vardy, A., Gentet, L. J., & Lambert, J. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.021 · Cited by 160 · see citing works
The Neurosteroid, 3α‐Hydroxy‐5α‐pregnan‐20‐one, Protects against Bicuculline‐Induced Seizures during Ethanol Withdrawal in Rats
Devaud, L. L., Purdy, R. H., & Morrow, A. L. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01514.x · Cited by 158 · see citing works
δ Subunit Inhibits Neurosteroid Modulation of GABAAReceptors
Zhu, W. J., Wang, J. F., Krueger, K. E., & Vicini, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06648.1996 · Cited by 156 · see citing works
Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences
Cavelier, P., Hamann, M., Rossi, D. J., Mobbs, P. G., & Attwell, D. (2004) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2004.06.001 · Cited by 156 · see citing works
Self-citation
Allopregnanolone Affects Sleep in a Benzodiazepine-Like Fashion
Lancel, M., Faulhaber, J., Schiffelholz, T., Romeo, E., di Michele, F., Holsboer, F., & Rupprecht, R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36959-9 · Cited by 150 · see citing works
GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride
Pierucci‐Lagha, A., Covault, J., Feinn, R., Nellissery, M. J., Hernández–Ávila, C. A., Oncken, C. A., Morrow, A. L., & Kranzler, H. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300688 · Cited by 146 · see citing works
GABAA receptor subtypes: the ‘one glass of wine’ receptors
Olsen, R. W., Hanchar, H. J., Meera, P., & Wallner, M. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.04.006 · Cited by 142 · see citing works
Steroid hormone fluctuations and GABAAR plasticity
Maguire, J. L., & Módy, I. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.019 · Cited by 139 · see citing works
Dose-response effects of ethanol on the sleep of young women.
Williams, D. L., MacLean, A., & Cairns, J. (1983) · Journal of Studies on Alcohol · doi:10.15288/jsa.1983.44.515 · Cited by 137 · see citing works
Neurosteroids Enhance Spontaneous Glutamate Release in Hippocampal Neurons
Meyer, D. A., Carta, M., Partridge, L. D., Covey, D. F., & Valenzuela, C. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202592200 · Cited by 132 · see citing works
Altered Pharmacology of Synaptic and Extrasynaptic GABAA Receptors on CA1 Hippocampal Neurons Is Consistent with Subunit Changes in a Model of Alcohol Withdrawal and Dependence
Liang, J., Cagetti, E., Olsen, R. W., & Spigelman, I. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.067983 · Cited by 127 · see citing works
Effects of Alcohol on Polysomnographically Recorded Sleep in Healthy Subjects
Feige, B., Gann, H., Brueck, R. K., Hornyak, M., Litsch, S., Hohagen, F., & Riemann, D. W. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00184.x · Cited by 126 · see citing works
Adolescents and androgens, receptors and rewards
Sato, S. M., Schulz, K. M., Sisk, C. L., & Wood, R. I. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.01.010 · Cited by 124 · see citing works
Alcohol and Endogenous Sex Steroid Levels in Postmenopausal Women: A Cross-Sectional Study
Onland‐Moret, N. C., Peeters, P. H. M., van der Schouw, Y. T., Grobbee, D. E., & van Gils, C. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0614 · Cited by 120 · see citing works
Sleep Following Alcohol Intoxication in Healthy, Young Adults: Effects of Sex and Family History of Alcoholism
Arnedt, J. T., Rohsenow, D. J., Almeida, A. B., Hunt, S. K., Gokhale, M., Gottlieb, D. J., & Howland, J. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01417.x · Cited by 118 · see citing works
Epidemiological trends in drinking by age and gender: Providing normative feedback to adults
Osilla, K. C., Neighbors, C., Gilson, M. S., Larimer, M. E., & Marlatt, G. A. (2006) · Addictive Behaviors · doi:10.1016/j.addbeh.2006.07.003 · Cited by 118 · see citing works
Drug discrimination analysis of endogenous neuroactive steroids in rats
Ator, N. A., Grant, K. A., Purdy, R. H., Paul, S. M., & Griffiths, R. R. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90208-y · Cited by 116 · see citing works
Self-citation
Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist
Breese, G. R., Knapp, D. J., & Overstreet, D. H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300282 · Cited by 115 · see citing works
Sulfated steroids as endogenous neuromodulators
Gibbs, T. T., Russek, S. J., & Farb, D. H. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.031 · Cited by 114 · see citing works
The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone.
Janak, P. H., Redfern, J. E. M., & Samson, H. H. (1998) · PubMed · Cited by 111 · see citing works
Neuroendocrine mechanisms of change in food intake during pregnancy: A potential role for brain oxytocin
Douglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 109 · see citing works
Impact of beta and gamma variants on ligand-binding properties of gamma-aminobutyric acid type A receptors.
Lüddens, H., Seeburg, P. H., & Korpi, E. R. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10192-2 · Cited by 109 · see citing works
Anticonvulsant Activity of Androsterone and Etiocholanolone
Kaminski, R. M., Marini, H. R., Kim, W., & Rogawski, M. A. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00705.x · Cited by 108 · see citing works
The discriminative stimulus effects of ethanol are mediated by NMDA and GABA A receptors in specific limbic brain regions
Hodge, C. W., & Cox, A. A. (1998) · Psychopharmacology · doi:10.1007/s002130050694 · Cited by 108 · see citing works
DSM-IV alcohol dependence and abuse: Further evidence of validity in the general population☆
Grant, B. F., Harford, T. C., Muthén, B., Yi, H., Hasin, D. S., & Stinson, F. S. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.05.019 · Cited by 108 · see citing works
Testosterone as a biological marker in psychopathy and alcoholism
Stålenheim, E. G., Eriksson, E., von Knorring, L., & WIDE, L. E. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(97)00143-1 · Cited by 104 · see citing works
The Reinforcing Effects of Ethanol Are Altered by the Endogenous Neurosteroid, Allopregnanolone
Janak, P. H., Redfern, J. E. M., & Samson, H. H. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03708.x · Cited by 104 · see citing works
Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function
Cagetti, E., Pinna, G., Guidotti, A., Baicy, K., & Olsen, R. W. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.10.001 · Cited by 103 · see citing works
Update on the Neurobiology of Alcohol Withdrawal Seizures
Rogawski, M. A. (2005) · Epiliepsy currents/Epilepsy currents · doi:10.1111/j.1535-7511.2005.00071.x · Cited by 101 · see citing works
Effects of PhD examination stress on allopregnanolone and cortisol plasma levels and peripheral benzodiazepine receptor density
Fortuyn, H. A. D., van Broekhoven, F., Span, P. N., Bäckström, T. C., Zitman, F. G., & Verkes, R. J. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.02.003 · Cited by 100 · see citing works
Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood
Muller, D. C., Giles, G. G., Bassett, J. K., Morris, H. A., Manning, J. T., Hopper, J. L., English, D. R., & Severi, G. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-57 · Cited by 100 · see citing works
Impact of Alcoholism on Sleep Architecture and EEG Power Spectra in Men and Women
Colrain, I. M., Turlington, S. R., & Baker, F. C. (2009) · SLEEP · doi:10.1093/sleep/32.10.1341 · Cited by 99 · see citing works
Tolerance to allopregnanolone with focus on the GABA‐A receptor
Türkmen, Ş., Bäckström, T. C., Wahlström, G., Andréen, L., & Johansson, I. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01059.x · Cited by 97 · see citing works
GABA‐mediated Ca2+ signalling in developing rat cerebellar Purkinje neurones
Eilers, J., Plant, T. D., Marandi, N., & Konnerth, A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0429c.xd · Cited by 96 · see citing works
The sticky issue of neurosteroids and GABAA receptors
Chisari, M., Eisenman, L. N., Covey, D. F., Mennerick, S. J., & Zorumski, C. F. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.03.005 · Cited by 96 · see citing works
Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
Morrow, A., Porcu, P., Boyd, K. N., & Grant, K. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/amorrow · Cited by 94 · see citing works
Self-citation
A Review of the Effects of Prenatal or Early Postnatal Ethanol Exposure on Brain Ligand‐Gated Ion Channels
da Costa, E. T., Savage, D. D., & Valenzuela, C. F. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02043.x · Cited by 92 · see citing works
Extrasynaptic δ-containing GABA A receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake
Nie, H., Rewal, M., Gill, T. M., Dorit Ron, A., & Janak, P. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016156108 · Cited by 90 · see citing works
Ethanol-enhanced GABA release: A focus on G protein-coupled receptors
Kelm, M. K., Criswell, H. E., & Breese, G. R. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.09.003 · Cited by 88 · see citing works
Prevalence, trends, and incidence of alcohol withdrawal symptoms: analysis of general population and clinical samples.
Caetano, R., Clark, C. L., & Greenfield, T. K. (1998) · PubMed · Cited by 87 · see citing works
Ethanol Modulates Synaptic and Extrasynaptic GABAA Receptors in the Thalamus
Jia, F., Chandra, D., Homanics, G. E., & Harrison, N. L. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.139303 · Cited by 86 · see citing works
Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAAreceptors as an opportunity for drug development?
Wallner, M., & Olsen, R. W. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.32 · Cited by 82 · see citing works
Stress, ethanol, and neuroactive steroids
Biggio, G., Concas, A., Follesa, P., Sanna, E., & Serra, M. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.005 · Cited by 82 · see citing works
Site of Action of Acute Alcohol Administration in Stimulating the Rat Hypothalamic-Pituitary-Adrenal Axis: Comparison between the Effect of Systemic and Intracerebroventricular Injection of this Drug on Pituitary and Hypothalamic Responses
Lee, S., Selvage, D. J., Hansen, K. S., & RIVIER, C. L. (2004) · Endocrinology · doi:10.1210/en.2004-0110 · Cited by 82 · see citing works
Mechanisms of sleep induction by GABA(A) receptor agonists.
Harrison, N. L. (2007) · PubMed · Cited by 81 · see citing works
Developmental maturation of synaptic and extrasynaptic GABAAreceptors in mouse thalamic ventrobasal neurones
Peden, D. R., Petitjean, C. M., Herd, M. B., Durakoglugil, M. S., Rosahl, T. W., Wafford, K. A., Homanics, G. E., Belelli, D., Fritschy, J., & Lambert, J. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.145375 · Cited by 81 · see citing works
Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in femaleMacaca fascicularis monkeys
Grant, K. A., Azarov, A. V., Bowen, C. A., Mirkis, S., & Purdy, R. H. (1996) · Psychopharmacology · doi:10.1007/bf02247439 · Cited by 77 · see citing works
Self-citation
Differential Change in Neuroactive Steroid Sensitivity during Ethanol Withdrawal
Finn, D. A., Gallaher, E. J., & Crabbe, J. C. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35305-4 · Cited by 76 · see citing works
Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder
Galindo, R., Zamudio, P. A., & Valenzuela, C. F. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03294.x · Cited by 75 · see citing works
Sleep and the cholinergic rapid eye movement sleep induction test in patients with primary alcohol dependence
Gann, H., Feige, B., Hohagen, F., van Calker, D., Geiss, D., & Riemann, D. W. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01172-6 · Cited by 75 · see citing works
Neurosteroids in the brain of handling-habituated and naive rats: effect of CO2 inhalation
Barbaccia, M. L., Roscetti, G., Trabucchi, M., Cuccheddu, T., Concas, A., & Biggio, G. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90123-6 · Cited by 73 · see citing works
Discriminative stimulus effects of ethanol and 3α-hydroxy-5α-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys ( Macaca fascicularis )
Grant, K. A., Azarov, A. V., Shively, C. A., & Purdy, R. H. (1997) · Psychopharmacology · doi:10.1007/s002130050211 · Cited by 70 · see citing works
Self-citation
Inhibition of thalamic excitability by 4,5,6,7‐tetrahydroisoxazolo[4,5‐c]pyridine‐3‐ol: a selective role for δ‐GABAAreceptors
Herd, M. B., Foister, N., Chandra, D., Peden, D. R., Homanics, G. E., Brown, V. J., Balfour, D. J. K., Lambert, J. J., & Belelli, D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06680.x · Cited by 69 · see citing works
Studies of ethanol actions on recombinant δ-containing γ-aminobutyric acid type A receptors yield contradictory results
Borghese, C. M., & Harris, R. A. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.03.006 · Cited by 68 · see citing works
Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors
Finn, D. A., Beckley, E. H., Kaufman, K. R., & Ford, M. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.07.002 · Cited by 68 · see citing works
Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies
Botta, P., Radcliffe, R. A., Carta, M., Mameli, M., Daly, E., Floyd, K. L., Deitrich, R. A., & Valenzuela, C. F. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.04.004 · Cited by 67 · see citing works
Pregnenolone and Ganaxolone Reduce Operant Ethanol Self‐Administration in Alcohol‐Preferring P Rats
Besheer, J., Lindsay, T. G., O’Buckley, T. K., et al. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01300.x · Cited by 66 · see citing works
Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats
Devaud, L. L., Fritschy, J., & Morrow, A. L. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00357-6 · Cited by 66 · see citing works
Ethanol-Like Discriminative Stimulus Effects of Endogenous Neuroactive Steroids: Effect of Ethanol Training Dose and Dosing Procedure
Bowen, C. A., Purdy, R. H., & Grant, K. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38150-9 · Cited by 65 · see citing works
Self-citation
Social isolation‐induced increase in α4and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAAreceptor function
Serra, M., Mostallino, M. C., Talani, G., Pisu, M. G., Carta, M., Mura, M. L., Floris, I., Maciocco, E., Sanna, E., & Biggio, G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03850.x · Cited by 63 · see citing works
Effects of ethanol at four phases of the menstrual cycle
Holdstock, L., & de Wit, H. (2000) · Psychopharmacology · doi:10.1007/s002130000461 · Cited by 61 · see citing works
Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol
Pierucci‐Lagha, A., Covault, J., Feinn, R., Khisti, R. T., Morrow, A. L., Marx, C. E., Shampine, L. J., & Kranzler, H. R. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0231-0 · Cited by 60 · see citing works
Discriminative Stimulus Effects of Ethanol in C57BL/6J and DBA/2J Inbred Mice
Shelton, K. L., & Grant, K. A. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02601.x · Cited by 58 · see citing works
Self-citation
Physiologcal variatins in the ovarian production of 5α-pregnane derivatives with sedative properties in the rat
Holzbauer, M. (1975) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(75)90357-x · Cited by 57 · see citing works
Differential Effects of Ethanol on Serum GABAergic 3α,5α/3α,5β Neuroactive Steroids in Mice, Rats, Cynomolgus Monkeys, and Humans
Porcu, P., O’Buckley, T. K., Alward, S. E., Song, S. C., Grant, K. A., de Wit, H., & Morrow, A. L. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01123.x · Cited by 56 · see citing works
Self-citation
Alcohol effects on γ-aminobutyric acid type A receptors: are extrasynaptic receptors the answer?
Hanchar, H. J., Wallner, M., & Olsen, R. W. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.05.035 · Cited by 56 · see citing works
The Effects of Gonadectomy on Age- and Sex-Typical Patterns of Ethanol Consumption in Sprague-Dawley Rats: EFFECTS OF GONADECTOMY ON ETHANOL CONSUMPTION
Vetter-O’Hagen, C. S., & Spear, L. P. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01555.x · Cited by 55 · see citing works
Social isolation‐induced increase in the sensitivity of rats to the steroidogenic effect of ethanol
Serra, M., Pisu, M. G., Floris, I., Cara, V., Purdy, R. H., & Biggio, G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01680.x · Cited by 53 · see citing works
The Influence of Subchronic Administration of the Neurosteroid Allopregnanolone on Sleep in the Rat
Damianisch, K. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00242-1 · Cited by 53 · see citing works
The Role of Protein Kinase A in the Ethanol-Induced Increase in Spontaneous GABA Release Onto Cerebellar Purkinje Neurons
Kelm, M. K., Criswell, H. E., & Breese, G. R. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90970.2008 · Cited by 53 · see citing works
Comparison of chronic ethanol and chronic intermittent ethanol treatments on the expression of GABAA and NMDA receptor subunits
Rani, C. S. S., & Ticku, M. K. (2006) · Alcohol · doi:10.1016/j.alcohol.2006.05.002 · Cited by 52 · see citing works
Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction
Hill, M., Popov, P., Havlı́ková, H., et al. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.013 · Cited by 50 · see citing works
Characterization of the discriminative stimulus effects of GABA A receptor ligands in Macaca fascicularis monkeys under different ethanol training conditions
Grant, K. A., Waters, C. A., Green-Jordan, K., et al. (2000) · Psychopharmacology · doi:10.1007/s002130000510 · Cited by 49 · see citing works
Self-citation
Voluntary Ethanol Consumption Induced by Social Isolation Reverses the Increase of α4/δ GABAA Receptor Gene Expression and Function in the Hippocampus of C57BL/6J Mice
Sanna, E., Talani, G., Obili, N., Mascia, M. P., Mostallino, M. C., Secci, P. P., Pisu, M. G., Biggio, F., Utzeri, C., Olla, P., et al. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00015 · Cited by 48 · see citing works
Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release andde novoadrenal StAR synthesis
Boyd, K. N., Kumar, S., O’Buckley, T. K., Porcu, P., & Morrow, A. L. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06509.x · Cited by 48 · see citing works
Binge-Pattern Alcohol Exposure during Puberty Induces Long-Term Changes in HPA Axis Reactivity
Przybycien–Szymanska, M. M., Mott, N. N., Paul, C. R., Gillespie, R. A., & Pak, T. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018350 · Cited by 48 · see citing works
Effects of voluntary ethanol consumption on emotional state and stress responsiveness in socially isolated rats
Pisu, M. G., Mostallino, M. C., Dore, R., Maciocco, E., Secci, P. P., & Serra, M. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.07.006 · Cited by 46 · see citing works
Characterization of Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone
Engel, S. R., Purdy, R. H., & Grant, K. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29561-6 · Cited by 45 · see citing works
Self-citation
Tolerance to Sedative/Hypnotic Actions of GABAergic Drugs Correlates With Tolerance to Potentiation of Extrasynaptic Tonic Currents of Alcohol-Dependent Rats
Liang, J., Spigelman, I., & Olsen, R. W. (2009) · Journal of Neurophysiology · doi:10.1152/jn.90484.2008 · Cited by 44 · see citing works
Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol
Ramaker, M. J., Ford, M. M., Fretwell, A. M., & Finn, D. A. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01551.x · Cited by 43 · see citing works
Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol
Módy, I. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.07.010 · Cited by 43 · see citing works
Brain Regional Differences in the Effect of Ethanol on GABA Release from Presynaptic Terminals
Criswell, H. E., Ming, Z., Kelm, M. K., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.135418 · Cited by 42 · see citing works
Allopregnanolone modulates spontaneous GABA release via presynaptic Cl− permeability in rat preoptic nerve terminals
Haage, D., Druzin, M., & Johansson, S. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03704-6 · Cited by 41 · see citing works
Sex Differences in Steroid Modulation of Ethanol Withdrawal in Male and Female Rats
Alele, P. E., & Devaud, L. L. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107896 · Cited by 41 · see citing works
Plasticity of GABAA Receptors after Ethanol Pre-Exposure in Cultured Hippocampal Neurons
Shen, Y., Lindemeyer, A. K., Spigelman, I., Sieghart, W., Olsen, R. W., & Liang, J. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.068650 · Cited by 40 · see citing works
Sex differences in acoustic startle responses and seizure thresholds between ethanol-withdrawn male and female rats
Reilly, W., Koirala, B., & Devaud, L. L. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agp049 · Cited by 40 · see citing works
Tonic GABAergic control of mouse dentate granule cells during postnatal development
Holter, N. I., Zylla, M. M., Zuber, N., Bruehl, C., & Draguhn, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07331.x · Cited by 39 · see citing works
Clinical Neuropharmacology of Drugs of Abuse: A Comparison of Drug-Discrimination and Subject-Report Measures
Kelly, T. H., Stoops, W. W., Perry, A. S., Prendergast, M., & Rush, C. R. (2003) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582303262095 · Cited by 39 · see citing works
Ethanol‐Induced Regulation of GABAA Subunit mRNAs in Prefrontal Fields of Cynomolgus Monkeys
Hemby, S. E., O’Connor, J. A., Acosta, G., Floyd, D., Anderson, N., McCool, B. A., Friedman, D. P., & Grant, K. A. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00254.x · Cited by 38 · see citing works
Self-citation
Testosterone and Alcohol Use among Adolescent Male Twins: Testing Between-Family Associations in Within-Family Comparisons
Eriksson, C. J. P., Kaprio, J. A., Pulkkinen, L., & Rose, R. J. (2005) · Behavior Genetics · doi:10.1007/s10519-005-3228-x · Cited by 37 · see citing works
Characterization of the discriminative stimulus effects of N -methyl- D -aspartate ligands under different ethanol training conditions in the cynomolgus monkey ( Macaca fascicularis )
Vivian, J. A., Waters, C. A., Szeliga, K. T., et al. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1086-2 · Cited by 37 · see citing works
Allopregnanolone and Pentobarbital Infused Into the Nucleus Accumbens Substitute for the Discriminative Stimulus Effects of Ethanol
Hodge, C. W., Nannini, M., Olive, M. F., et al. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02145.x · Cited by 37 · see citing works
Modulation of glutamatergic transmission by sulfated steroids: Role in fetal alcohol spectrum disorder
Valenzuela, C. F., Partridge, L., Mameli, M., & Meyer, D. A. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.009 · Cited by 36 · see citing works
Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice
Gorin-Meyer, R. E., Wiren, K. M., Tanchuck, M. A., Long, S. L., Yoneyama, N., & Finn, D. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.051 · Cited by 35 · see citing works
Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood
Darbra, S., & Pallarés, M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.08.020 · Cited by 35 · see citing works
The Effect of Alcohol on Testosterone Concentrations in Alcohol‐Preferring and Non‐Preferring Rat Lines
Apter, S., & Eriksson, C. J. P. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000075832.83254.81 · Cited by 34 · see citing works
Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys
Acosta, G., Hasenkamp, W. M., Daunais, J. B., Friedman, D. P., Grant, K. A., & Hemby, S. E. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.050 · Cited by 33 · see citing works
Self-citation
Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the α6 GABAA Receptor Subunit
Botta, P., Mameli, M., Floyd, K. L., Radcliffe, R. A., & Valenzuela, C. F. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.127894 · Cited by 33 · see citing works
Subcellular location of hypothalamic progesterone metabolizing enzymes and evidence for distinct NADH- and NADHP-linked 3α-hydroxysteroid oxidoreductase activities
Krause, J. E., & Karavolas, H. J. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90005-9 · Cited by 33 · see citing works
Neuroactive Steroid Stereospecificity of Ethanol-Like Discriminative Stimulus Effects in Monkeys
Grant, K. A., Helms, C. M., Rogers, L. S. M., & Purdy, R. H. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.137315 · Cited by 33 · see citing works
Self-citation
Discriminative Stimulus Effects of Ethanol in Mice Lacking the γ‐Aminobutyric Acid Type A Receptor δ Subunit
Shannon, E. E., Shelton, K. L., Vivian, J. A., Yount, I., Morgan, A. R., Homanics, G. E., & Grant, K. A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000128227.28794.42 · Cited by 32 · see citing works
Self-citation
Assessment of benzodiazepine receptor heterogeneity in vivo: apparent pA 2 and pK B analyses from behavioral studies
Rowlett, J. K., & Woolverton, W. L. (1996) · Psychopharmacology · doi:10.1007/s002130050103 · Cited by 32 · see citing works
Variations on an inhibitory theme: Phasic and tonic activation of GABA(A) receptors
Farrant, M., & Nusser, Z. (2005) · UCL Discovery (University College London) · Cited by 31 · see citing works
Discriminative Stimulus Effects of Drugs Acting at GABAA Receptors
Sanger, D. J., Griebel, G., Perrault, G., Claustre, Y., & Schoemaker, H. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00081-7 · Cited by 30 · see citing works
Kindling alters neurosteroid‐induced modulation of phasic and tonic GABAAreceptor‐mediated currents: role of phosphorylation
Kia, A., Ribeiro, F. M., Nelson, R. S., Gavrilovici, C., Ferguson, S. S. G., & Poulter, M. O. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07156.x · Cited by 30 · see citing works
Allopregnanolone has no effect on startle response and prepulse inhibition of startle response in patients with premenstrual dysphoric disorder or healthy controls
Kask, K., Bäckström, T. C., Lundgren, P., & Poromaa, I. S. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.02.014 · Cited by 30 · see citing works
Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats
ODELL, L., Purdy, R. E., Covey, D. F., RICHARDSON, H., Roberto, M., & Koob, G. F. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.03.020 · Cited by 30 · see citing works
Pre- and postsynaptic modulation of spinal GABAergic neurotransmission by the neurosteroid, 5β-pregnan-3α-ol-20-one
Reith, C. A., & Sillar, K. T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00809-3 · Cited by 29 · see citing works
Evidence for suppressant effects of testosterone on sex-typical ethanol intake in male Sprague-Dawley rats
Vetter-O’Hagen, C. S., Sanders, K. W., & SPEAR, L. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.06.020 · Cited by 28 · see citing works
The promnesic neurosteroid pregnenolone sulfate increases paradoxical sleep in rats
Darnaudéry, M., Bouyer, J. J., Pallarés, M., Moal, M. L., & Mayo, W. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01338-9 · Cited by 27 · see citing works
Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses
Zamudio, P. A., & Valenzuela, C. F. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.063 · Cited by 27 · see citing works
Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats
Sharma, A. N., Chopde, C. T., Hirani, K., Kokare, D. M., & Ugale, R. R. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.025 · Cited by 27 · see citing works
Sex Differences in Brain and Plasma β-Endorphin Content following Testosterone, Dihydrotestosterone and Estradiol Administration to Gonadectomized Rats
Pluchino, N., Ninni, F., Casarosa, E., Giannini, A., Merlini, S., Cubeddu, A., Luisi, M., Cela, V., & Genazzani, A. R. (2009) · Neuroendocrinology · doi:10.1159/000209506 · Cited by 27 · see citing works
The Influence of Menstrual Cycle Phase on Sensitivity to Ethanol-Like Discriminative Stimulus Effects of GABAA-Positive Modulators
Green, K. A. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00057-x · Cited by 27 · see citing works
The role of testosterone in the development of experimental alcoholism.
Gn, L., & Nk, B. (1980) · PubMed · Cited by 27 · see citing works
Failure of $gamma;-hydroxybutyric acid both to increase neuroactive steroid concentrations in adrenalectomized?orchiectomized rats and to induce tolerance to its steroidogenic effect in intact animals
Porcu, P., Sogliano, C., Ibba, C., Piredda, M., Tocco, S., Marra, C., Purdy, R. H., Biggio, G., & Concas, A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.03.059 · Cited by 26 · see citing works
Hypothalamic–pituitary–adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
Porcu, P., Grant, K. A., Green, H., Rogers, L. S. M., & Morrow, A. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0132-2 · Cited by 26 · see citing works
Self-citation
Fat distribution and steroid hormones in women with alcohol abuse
PETTERSSON, P., Ellsinger, B. M., Sjöberg, C., & Björntorp, P. A. (1990) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1990.tb00238.x · Cited by 26 · see citing works
The effects of the neuroactive steroid 3α,5α-THDOC on sleep in the rat
Müller-Preuss, P., Rupprecht, R., & Lancel, M. (2002) · Neuroreport · doi:10.1097/00001756-200203250-00026 · Cited by 26 · see citing works
Characterization of the Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone in DBA/2J and C57BL/6J Inbred Mice
Shannon, E. E., Porcu, P., Purdy, R. H., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.082644 · Cited by 26 · see citing works
Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: Mechanisms and reversal by exogenous ACTH
Boyd, K. N., Kumar, S., O’Buckley, T. K., & Morrow, A. L. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06904.x · Cited by 23 · see citing works
High doses of systemic DHEA-sulfate do not affect sleep structure and elicit moderate changes in non-REM sleep EEG in rats
Schiffelholz, T., Holsboer, F., & Lancel, M. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00218-3 · Cited by 23 · see citing works
The Role of Neuroactive Steroids in Ethanol/Stress Interactions Proceedings of Symposium VII at the Volterra Conference on Alcohol and Stress, May 2008
Morrow, A., Biggio, G., Serra, M., Becker, H., Lopez, M. F., Porcu, P., Alward, S. E., & O'Buckley, T. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.04.002 · Cited by 22 · see citing works
Antagonism of the Ethanol-Like Discriminative Stimulus Effects of Ethanol, Pentobarbital, and Midazolam in Cynomolgus Monkeys Reveals Involvement of Specific GABAA Receptor Subtypes
Helms, C. M., Rogers, L. S. M., & Grant, K. A. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.156810 · Cited by 21 · see citing works
Self-citation
Abnormal Testosterone Excretion in Men Alcoholics
Fabre, L. F., Pasco, P. J., Liegel, J. M., et al. (1973) · Quarterly Journal of Studies on Alcohol · doi:10.15288/qjsa.1973.34.057 · Cited by 21 · see citing works
Effects of neurosteroids on the human corticotropin-releasing hormone gene
Budziszewska, B., Zając, A., Basta‐Kaim, A., Leśkiewicz, M., Steczkowska, M., Lasoń, W., & Kaciński, M. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70365-0 · Cited by 21 · see citing works
Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects.
Porcu, P., O'Buckley, T., Morrow, A. L., & Adinoff, B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.11.003 · Cited by 18 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

Choi D. S. Wei W. Deitchman J. K. Kharazia V. N. Lesscher H. M. McMahon T. Wang D. Qi Z. H. Sieghart W. Zhang C. Shokat K. M. Modi I. Messing R. O. (2008). Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J. Neurosci. 28, 11890– 11899 10.1523/JNEUROSCI.3259-08.2008 19005054 PMC2688726 · DOI
Hotchkiss J. Knobil E. (1994). “The menstrual cycle and its neuroendocrine control,” in The Physiology of Reproduction, 2nd Edn, eds Knobil E. Neill J. D. (New York: Raven Press), 711– 749
Kelly T. H. Fredenburg A. M. Emurian C. S. Martin C. A. Hays L. R. Rush C. R. (2001). Discriminative stimulus effects of triazolam: influence of menstrual cycle phase. Drug Alcohol Depend. 63, S3– S178 10.1016/S0376-8716(01)00133-8 · DOI

Sorted by citations

An emerging circuit pharmacology of GABAA receptors
Engin, E., Benham, R. S., & Rudolph, U. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.04.003 · Cited by 225 · see citing works

Authors: Helms, C. M., Rossi, D. J., & Grant, K. A.
Affiliations: Oregon National Primate Research Center (US)
Oregon Health & Science University (US)
Corresponding author: Helms, Christa M.
ORCID: Rossi, David J.
Grant, Kathleen A.
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2012
Volume: 3
Pages: 10-10
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2012.00010
PMC: PMC3356014
OpenAlex: W2169076325
Cited by: 30
References: 224
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 1
FWCI: 1.45
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Frontiers in Endocrinology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute on Alcohol Abuse and Alcoholism (P60AA010760, R24AA019431)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: neurosteroids, ethanol sensitivity, GABAA receptor, NMDA receptor, allopregnanolone, tetrahydrodeoxycorticosterone, alcoholism, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, chronic ethanol exposure, alcohol metabolism, drug discrimination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurosteroid influences on sensitivity to ethanol

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks