Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer
Open accessAbstract
BACKGROUND: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines. METHODS: Relevant articles through December 2008 were reviewed by the task force and categorized by topic and level of evidence according to a modified schema used by the United States Preventative Services Task Force. RESULTS: The revised guidelines for the management of thyroid nodules include recommendations regarding initial evaluation, clinical and ultrasound criteria for fine-needle aspiration biopsy, interpretation of fine-needle aspiration biopsy results, and management of benign thyroid nodules. Recommendations regarding the initial management of thyroid cancer include those relating to optimal surgical management, radioiodine remnant ablation, and suppression therapy using levothyroxine. Recommendations related to long-term management of differentiated thyroid cancer include those related to surveillance for recurrent disease using ultrasound and serum thyroglobulin as well as those related to management of recurrent and metastatic disease. CONCLUSIONS: We created evidence-based recommendations in response to our appointment as an independent task force by the American Thyroid Association to assist in the clinical management of patients with thyroid nodules and differentiated thyroid cancer. They represent, in our opinion, contemporary optimal care for patients with these disorders.
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- Authors
- Cooper, D. S., Doherty, G. M., Haugen, B. R., Kloos, R. T., Lee, S. L., Mandel, S. J., Mazzaferri, E. L., McIver, B., Pacini, F., Schlumberger, M., Sherman, S. I., Steward, D. L., & Tuttle, R. M.
- Affiliations
- Johns Hopkins University (US)
- University of Michigan (US)
- University of Colorado Health Sciences Center, Denver, Colorado.
- The Ohio State University (US)
- Boston University (US)
- University of Pennsylvania (US)
- University of Florida Health (US)
- Mayo Clinic (US)
- University of Siena (IT)
- Institut Gustave Roussy (FR)
- The University of Texas MD Anderson Cancer Center (US)
- University of Cincinnati Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- ORCID
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2009-11
- Volume
- 19
- Issue
- 11
- Pages
- 1167-1214
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2116542352
- Cited by
- 6,707
- References
- 614
- Citations by year
- 2026: 73 · 2025: 140 · 2024: 172 · 2023: 202 · 2022: 234 · 2021: 284 · 2020: 313 · 2019: 299 · 2018: 351 · 2017: 400 · 2016: 603 · 2015: 843 · 2014: 758 · 2013: 688 · 2012: 589
- FWCI
- 322.85
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- Amgen
- AstraZeneca
- Celgene
- Exelixis
- Veracyte
- Eisai
- Plexxikon
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- thyroid nodules, differentiated thyroid cancer, fine-needle aspiration, ultrasound-guided biopsy, benign thyroid nodules, thyroid surgery, radioiodine remnant ablation, levothyroxine suppression therapy, recurrence monitoring, metastatic thyroid cancer
- MeSH terms
- Adenocarcinoma, Carcinoma, Papillary, Combined Modality Therapy, Diagnosis, Differential, Humans, Iodine Radioisotopes, Lymph Nodes, Neck, Physical Examination, Prognosis, Thyroid Gland, Thyroid Neoplasms, United States, Treatment Outcome, Disease Progression, Biopsy, Fine-Needle
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