Regulation of Gastrointestinal Motility by Motilin and Ghrelin in Vertebrates
Open accessAbstract
The energy balance of vertebrates is regulated by the difference in energy input and energy expenditure. Generally, most vertebrates obtain their energy from nutrients of foods through the gastrointestinal (GI) tract. Therefore, food intake and following food digestion, including motility of the GI tract, secretion and absorption, are crucial physiological events for energy homeostasis. GI motility changes depending on feeding, and GI motility is divided into fasting (interdigestive) and postprandial (digestive) contraction patterns. GI motility is controlled by contractility of smooth muscles of the GI tract, extrinsic and intrinsic neurons (motor and sensory) and some hormones. In mammals, ghrelin (GHRL) and motilin (MLN) stimulate appetite and GI motility and contribute to the regulation of energy homeostasis. GHRL and MLN are produced in the mucosal layer of the stomach and upper small intestine, respectively. GHRL is a multifunctional peptide and is involved in glucose metabolism, endocrine/exocrine functions and cardiovascular and reproductive functions, in addition to feeding and GI motility in mammals. On the other hand, the action of MLN is restricted and species such as rodentia, including mice and rats, lack MLN peptide and its receptor. From a phylogenetic point of view, GHRL and its receptor GHS-R1a have been identified in various vertebrates, and their structural features and various physiological functions have been revealed. On the other hand, MLN or MLN-like peptide (MLN-LP) and its receptors have been found only in some fish, birds and mammals. Here, we review the actions of GHRL and MLN with a focus on contractility of the GI tract of species from fish to mammals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ginger may raise circulating concentrations of ghrelin.
“ginger may raise circulating concentrations of ghrelin, which stimulates GI motility in mammals [39, 40].”
From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [40]
The GHRL > Mammals > Human section (page unavailable) reports that ghrelin stimulates gastric motility and accelerates gastric emptying in healthy human volunteers. It does not address whether ginger raises circulating ghrelin; searches for ginger and ginger extract found no supporting passage. Thus the source supports the sentence’s ghrelin–motility clause, but not its ginger claim. (LLM, conf=0.85)
Experimental — accuracy not yet measuredGhrelin stimulates GI motility in mammals.
“ginger may raise circulating concentrations of ghrelin, which stimulates GI motility in mammals [39, 40].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · see citing works
Ghrelin: Structure and Function
Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810 · see citing works
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Howard, A., Feighner, S., Cully, D., Arena, J. P., Liberator, P., Rosenblum, C., Hamelin, M., Hreniuk, D. L., Palyha, O., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,106 · see citing works
The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.
Gnanapavan, S., Kola, B., Bustin, S., Morris, D., McGee, P. J., Fairclough, P., Bhattacharya, S., Carpenter, R., Grossman, A., & Korbonits, M. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.6.8739 · Cited by 1,507 · see citing works
Yang, J., Brown, M. S., Liang, G., Grishin, N., & Goldstein, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.017 · Cited by 1,191 · see citing works
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187 · see citing works
Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185 · see citing works
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
Asakawa, A., Inui, A., Kaga, O., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22158 · Cited by 1,175 · see citing works
Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats
Masuda, Y., Tanaka, T., Inomata, N., Ohnuma, N., Tanaka, S., Itoh, Z., Hosoda, H., Kojima, M., & Kangawa, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3568 · Cited by 884 · see citing works
Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway
Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M. S., Shimbara, T., Guan, J., Wang, Q., Funahashi, H., Sakurai, T., et al. (2003) · Endocrinology · doi:10.1210/en.2002-220788 · Cited by 462 · see citing works
Gastrointestinal hormones and food intake
Strader, A. D., & Woods, S. C. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.043 · Cited by 445 · see citing works
Gut Hormones and Appetite Control
Wren, A., & Bloom, S. R. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.048 · Cited by 434 · see citing works
Growth Hormone Secretagogue Binding Sites in Peripheral Human Tissues1
Papotti, M., Ghé, C., Cassoni, P., Catapano, F., Deghenghi, R., Ghigo, E., & Muccioli, G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6846 · Cited by 416 · see citing works
Receptor for Motilin Identified in the Human Gastrointestinal System
Feighner, S. D., Tan, C. P., McKee, K. K., Palyha, O. C., Hreniuk, D. L., Pong, S., Austin, C. P., Figueroa, D. J., MacNeil, D., Cascieri, M. A., et al. (1999) · Science · doi:10.1126/science.284.5423.2184 · Cited by 397 · see citing works
Motilin and the interdigestive migrating motor complex in man
Vantrappen, G., Janssens, J., Peeters, T. L., Bloom, S. R., Christofides, N. D., & Hellemans, J. (1979) · Digestive Diseases and Sciences · doi:10.1007/bf01489315 · Cited by 384 · see citing works
Influence of ghrelin on interdigestive gastrointestinal motility in humans
Tack, J., Depoortere, I., Bisschops, R., Delporte, C., Coulie, B., Meulemans, A., Janssens, J., & Peeters, T. (2005) · Gut · doi:10.1136/gut.2004.060426 · Cited by 359 · see citing works
Ghrelin Induces Fasted Motor Activity of the Gastrointestinal Tract in Conscious Fed Rats
Fujino, K., Inui, A., Asakawa, A., Kihara, N., Fujimura, M., & Fujimiya, M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040600 · Cited by 338 · see citing works
Vagal neurocircuitry and its influence on gastric motility
Travagli, R. A., & Anselmi, L. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.76 · Cited by 323 · see citing works
Ghrelin stimulates gastric emptying and hunger in normal-weight humans
Levin, F., Edholm, T., Schmidt, P. T., Grybäck, P., Jacobsson, H., Degerblad, M., Höybye, C., Holst, J. J., Rehfeld, J. F., Hellström, P. M., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2638 · Cited by 313 · see citing works
Saito, E.-S., Kaiya, H., Tachibana, T., Tomonaga, S., Denbow, D. M., Kangawa, K., & Furuse, M. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.09.003 · Cited by 304 · see citing works
Self-citationMcKee, K. K., Tan, C. P., Palyha, O. C., Liu, J., Feighner, S. D., Hreniuk, D. L., Smith, R. G., Howard, A. D., & der Ploeg, L. H. T. V. (1997) · Genomics · doi:10.1006/geno.1997.5069 · Cited by 296 · see citing works
Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog
Itoh, Z., Nakaya, M., Suzuki, T., Arai, H., & Wakabayashi, K. (1984) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1984.247.6.g688 · Cited by 296 · see citing works
Motilin-induced mechanical activity in the canine alimentary tract.
Itoh, Z., Honda, R., Hiwatashi, K., Takeuchi, S., AIZAWA, I., Takayanagi, R., & Ef, C. (1976) · PubMed · Cited by 293 · see citing works
Structure, regulation and function of ghrelin
Sato, T., Nakamura, Y., Shiimura, Y., Ohgusu, H., Kangawa, K., & Kojima, M. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr134 · Cited by 253 · see citing works
Motilin and Clinical Application
Itoh, Z. (1997) · Peptides · doi:10.1016/s0196-9781(96)00333-6 · Cited by 247 · see citing works
Motilin, a Gastric Motor Activity Stimulating Polypeptide: The Complete Amino Acid Sequence
Brown, J. C., Cook, M. A., & Dryburgh, J. R. (1973) · Canadian Journal of Biochemistry · doi:10.1139/o73-066 · Cited by 245 · see citing works
Chicken Ghrelin: Purification, cDNA Cloning, and Biological Activity
Kaiya, H., van der Geyten, S., Kojima, M., Hosoda, H., Kitajima, Y., Matsumoto, M., Geelissen, S. M. E., Darras, V. M., & Kangawa, K. (2002) · Endocrinology · doi:10.1210/en.2002-220255 · Cited by 243 · see citing works
Self-citationShark genomes provide insights into elasmobranch evolution and the origin of vertebrates
Hara, Y., Yamaguchi, K., Onimaru, K., Kadota, M., Koyanagi, M., Keeley, S. D., Tatsumi, K., Tanaka, K. Y., Motone, F., Kageyama, Y., et al. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0673-5 · Cited by 241 · see citing works
Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility
Chen, C., Asakawa, A., Fujimiya, M., Lee, S., & Inui, A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001958 · Cited by 239 · see citing works
Ghrelin: A multifunctional hormone in non-mammalian vertebrates
Kaiya, H., Miyazato, M., Kangawa, K., Peter, R. E., & Unniappan, S. (2008) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2007.12.004 · Cited by 227 · see citing works
Self-citationBrown, J. C., Mutt, V., & Dryburgh, J. R. (1971) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y71-047 · Cited by 226 · see citing works
Ghrelin: a new player in the control of gastrointestinal functions
Peeters, T. L. (2005) · Gut · doi:10.1136/gut.2004.062604 · Cited by 187 · see citing works
Strunz, U. T., Domschke, W., Mitznegg, P., Domschke, S., Schubert, E., Wünsch, E., Jaeger, E., & Demling, L. (1975) · Gastroenterology · doi:10.1016/s0016-5085(75)80136-3 · Cited by 184 · see citing works
Dass, N. B., Munonyara, M. L., Bassil, A. K., Hervieu, G. J., Osbourne, S., Corcoran, S. L., Morgan, M., & Sanger, G. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00327-0 · Cited by 182 · see citing works
Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus
Mondal, M. S., Date, Y., Yamaguchi, H., Toshinai, K., Tsuruta, T., Kangawa, K., & Nakazato, M. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.08.038 · Cited by 176 · see citing works
Kaiya, H., Kojima, M., Hosoda, H., Moriyama, S., Takahashi, A., Kawauchi, H., & Kangawa, K. (2003) · Endocrinology · doi:10.1210/en.2003-1085 · Cited by 173 · see citing works
Self-citationBullfrog Ghrelin Is Modified by n-Octanoic Acid at Its Third Threonine Residue*
Kaiya, H., Kojima, M., Hosoda, H., Kōda, A., Yamamoto, K., Kitajima, Y., Matsumoto, M., Minamitake, Y., Kikuyama, S., & Kangawa, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105212200 · Cited by 171 · see citing works
Self-citationFukuda, H., Mizuta, Y., Isomoto, H., Takeshima, F., Ohnita, K., Ohba, K., Omagari, K., Taniyama, K., & KOHNO, S. (2004) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520410007908 · Cited by 157 · see citing works
Depoortere, I., Winter, B. Y. D., Thijs, T., Man, J. D., Pelckmans, P. A., & Peeters, T. L. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.04.008 · Cited by 142 · see citing works
Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro
Kitazawa, T., Smet, B. D., Verbeke, K., Depoortere, I., & Peeters, T. L. (2005) · Gut · doi:10.1136/gut.2005.065896 · Cited by 139 · see citing works
Self-citationGrowth Hormone Secretagogue Receptor Family Members and Ligands
Smith, R. G., Leonard, R. J., Bailey, A. R. T., Palyha, O. C., Feighner, S. D., Tan, C. P., McKee, K. K., Pong, S., Griffin, P. R., & Howard, A. (2001) · Endocrine · doi:10.1385/endo:14:1:009 · Cited by 137 · see citing works
Erythromycin: a motilin agonist and gastrointestinal prokinetic agent.
Weber, F. H., Richards, R. D., & McCallum, R. W. (1993) · PubMed · Cited by 130 · see citing works
The translational value of rodent gastrointestinal functions: a cautionary tale
Sanger, G. J., Holbrook, J. D., & Andrews, P. L. R. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.03.009 · Cited by 124 · see citing works
Lee, K. Y., Chang, T. M., & Chey, W. Y. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.245.4.g547 · Cited by 122 · see citing works
Xu, L., Depoortere, I., Tomasetto, C., Zandecki, M., Tang, M., Timmermans, J., & Peeters, T. L. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.07.022 · Cited by 122 · see citing works
Shimizu, Y., Ed, C., Shafton, A. D., Ferens, D. M., Sanger, G. J., Witherington, J. J., & Furness, J. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116160 · Cited by 118 · see citing works
Ghrelin and the Regulation of Food Intake and Energy Balance
Hosoda, H. (2002) · Molecular Interventions · doi:10.1124/mi.2.8.494 · Cited by 116 · see citing works
Janssens, J., Vantrappen, G., & Peeters, T. L. (1983) · Regulatory Peptides · doi:10.1016/0167-0115(83)90265-3 · Cited by 115 · see citing works
The role of ghrelin in energy balance regulation in fish
Jönsson, E. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.03.013 · Cited by 113 · see citing works
Des-Acyl Ghrelin: A Metabolically Active Peptide
Delhanty, P. J. D., Neggers, S. J. C. M. M., & van der Lely, A. J. (2013) · Endocrine development · doi:10.1159/000346059 · Cited by 109 · see citing works
Takeshita, E., Matsuura, B., Dong, M., Miller, L. J., Matsui, H., & Onji, M. (2006) · Journal of Gastroenterology · doi:10.1007/s00535-005-1739-0 · Cited by 101 · see citing works
Ghrelin and Motilin Are Cosecreted from a Prominent Endocrine Cell Population in the Small Intestine
Wierup, N., Björkqvist, M., Weström, B. R., Pierzynowski, S. G., Sundler, F., & Sjölund, K. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2756 · Cited by 99 · see citing works
Motilin-induced gastric contractions signal hunger in man
Tack, J. F., Deloose, E., Ang, D., Scarpellini, E., Vanuytsel, T., Oudenhove, L. V., & Depoortere, I. (2014) · Gut · doi:10.1136/gutjnl-2014-308472 · Cited by 99 · see citing works
Shousha, S. A., Nakahara, K., Kojima, M., Miyazato, M., Hosoda, H., Kangawa, K., & Murakami, N. (2005) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2004.12.021 · Cited by 98 · see citing works
Peripheral ghrelin reduces food intake and respiratory quotient in chicken
Geelissen, S. M. E., Swennen, Q., der Geyten, S. V., Kühn, E. R., Kaiya, H., Kangawa, K., Decuypere, E. M. P., Buyse, J. G., & Darras, V. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.06.005 · Cited by 98 · see citing works
Self-citationStepwise loss of motilin and its specific receptor genes in rodents
He, J., Irwin, D. M., Chen, R., & Zhang, Y. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0095 · Cited by 97 · see citing works
Ariga, H., Tsukamoto, K., Chen, C., Mantyh, C. R., Pappas, T. N., & Takahashi, T. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00945.x · Cited by 97 · see citing works
Organization of the Mouse Ghrelin Gene and Promoter: Occurrence of a Short Noncoding First Exon
Tanaka, M., Hayashida, Y., Iguchi, T., Nakao, N., Nakai, N., & Nakashima, K. (2001) · Endocrinology · doi:10.1210/endo.142.8.8433 · Cited by 91 · see citing works
Olsson, C., Holbrook, J. D., Bompadre, G., Jönsson, E., Hoyle, C. H. V., Sanger, G. J., Holmgren, S., & Andrews, P. L. R. (2007) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2007.05.016 · Cited by 88 · see citing works
Purification, cDNA cloning, and characterization of ghrelin in channel catfish, Ictalurus punctatus
Kaiya, H., Small, B. C., Bilodeau, A. L., Shepherd, B. S., Kojima, M., Hosoda, H., & Kangawa, K. (2005) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.03.012 · Cited by 87 · see citing works
Self-citationBroad, J., Mukherjee, S., Samadi, M., Martin, J., Dukes, G. E., & Sanger, G. J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02009.x · Cited by 82 · see citing works
Actions of various gastrointestinal peptides on the isolated amphibian spinal cord
Phillis, J. W., & Kirkpatrick, J. (1979) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y79-136 · Cited by 80 · see citing works
Recent advances in the phylogenetic study of ghrelin
Kaiya, H., Miyazato, M., & Kangawa, K. (2011) · Peptides · doi:10.1016/j.peptides.2011.04.027 · Cited by 79 · see citing works
Self-citationGhrelin regulates gastric phase III‐like contractions in freely moving conscious mice
Zheng, J., Ariga, H., Taniguchi, H., Ludwig, K., & Takahashi, T. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01179.x · Cited by 79 · see citing works
The rabbit motilin receptor: molecular characterisation and pharmacology
Dass, N. B., Hill, J., Muir, A., Testa, T., Wise, A., & Sanger, G. J. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705505 · Cited by 77 · see citing works
Huang, J., Zhou, H., Mahavadi, S., Sriwai, W., Lyall, V., & Murthy, K. S. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00305.2004 · Cited by 75 · see citing works
Kaiya, H., Saito, E.-S., Tachibana, T., Furuse, M., & Kangawa, K. (2006) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2006.03.006 · Cited by 72 · see citing works
Self-citationOhno, T., Kamiyama, Y., Aihara, R., Nakabayashi, T., Mochiki, E., Asao, T., & Kuwano, H. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00747.x · Cited by 68 · see citing works
Ghrelin-induced GH secretion in domestic fowl in vivo and in vitro
Baudet, M., & Harvey, S. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1790097 · Cited by 67 · see citing works
Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus
Miura, T., Maruyama, K., Kaiya, H., Miyazato, M., Kangawa, K., Uchiyama, M., Shioda, S., & Matsuda, K. (2008) · Peptides · doi:10.1016/j.peptides.2008.12.016 · Cited by 67 · see citing works
Self-citationInterdigestive migrating motor complex -its mechanism and clinical importance
Takahashi, T. (2013) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.49.99 · Cited by 66 · see citing works
Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro
Kitazawa, T., Kaiya, H., & Taneike, T. (2006) · Peptides · doi:10.1016/j.peptides.2006.10.012 · Cited by 64 · see citing works
Self-citationHouse musk shrew (Suncus murinus, order: Insectivora) as a new model animal for motilin study
Tsutsui, C., Kajihara, K., Yanaka, T., Sakata, I., Itoh, Z., Oda, S., & Sakai, T. (2008) · Peptides · doi:10.1016/j.peptides.2008.10.006 · Cited by 61 · see citing works
Depoortere, I., Thijs, T., Thielemans, L. A., Robberecht, P., & Peeters, T. L. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047563 · Cited by 61 · see citing works
Prokineticin-2, motilin, ghrelin and metoclopramide: Prokinetic utility in mouse stomach and colon
Bassil, A. K., Dass, N. B., Murray, C. D., Muir, A. I., & Sanger, G. J. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.007 · Cited by 60 · see citing works
Deloose, E., Vos, R. D., Corsetti, M., Depoortere, I., & Tack, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12470 · Cited by 58 · see citing works
Kaiya, H., Kangawa, K., & Miyazato, M. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.10.015 · Cited by 58 · see citing works
Self-citationPérez‐Tomás, R., Ballesta, J., Pastor, L. M., Madrid, J. F., & Polak, J. M. (1989) · General and Comparative Endocrinology · doi:10.1016/0016-6480(89)90148-2 · Cited by 58 · see citing works
Assche, G. V., Depoortere, I., Thijs, T., Janssens, J. J., & Peeters, T. L. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01317-4 · Cited by 57 · see citing works
The erythromycin derivative EM-523 is a potent motilin agonist in man and in rabbit
Depoortere, I., Peeters, T. L., & Vantrappen, G. R. (1990) · Peptides · doi:10.1016/0196-9781(90)90052-7 · Cited by 55 · see citing works
Kaiya, H., Miura, T., Matsuda, K., Miyazato, M., & Kangawa, K. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.06.004 · Cited by 54 · see citing works
Self-citationd-Amino acid and alanine scans of the bioactive portion of porcine motilin
Peeters, T. L., Macielag, M. J., Depoortere, I., Konteatis, Z. D., Florance, J. R., Lessor, R. A., & Galdes, A. (1992) · Peptides · doi:10.1016/0196-9781(92)90014-t · Cited by 53 · see citing works
Kaiya, H., Sakata, I., Kojima, M., Hosoda, H., Sakai, T., & Kangawa, K. (2004) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2004.05.005 · Cited by 53 · see citing works
Self-citationRegulation of food intake by gastrointestinal hormones
Baynes, K., Dhillo, W. S., & Bloom, S. R. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000245537.43142.63 · Cited by 52 · see citing works
Effects of digestive status on the reptilian gut
Holmberg, A. H., Kaim, J., Persson, A., Jensen, J. M., Wang, T., & Holmgren, S. (2002) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(02)00257-x · Cited by 50 · see citing works
Miyano, Y., Sakata, I., Kuroda, K., Aizawa, S., Tanaka, T., Jogahara, T., Kurotani, R., & Sakai, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064777 · Cited by 49 · see citing works
Comparative stimulation of motilin duodenal receptor by porcine or canine motilin
Poitras, P., Lahaie, R. G., St-Pierre, S. A., & Trudel, L. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90014-x · Cited by 49 · see citing works
Mondal, A., Xie, Z., Miyano, Y., Tsutsui, C., Sakata, I., Kawamoto, Y., Aizawa, S., Tanaka, T., Oda, S.-I., & Sakai, T. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00379.2011 · Cited by 49 · see citing works
Blanco, A. M., Bertucci, J. I., Ramesh, N., Delgado, M. J., Valenciano, A. I., & Unniappan, S. (2017) · Scientific Reports · doi:10.1038/srep45024 · Cited by 47 · see citing works
Kaiya, H., Mori, T., Miyazato, M., & Kangawa, K. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.04.612 · Cited by 47 · see citing works
Self-citationDirect effects of motilin on isolated smooth muscle from various regions of the human stomach
L�dtke, F. E., M�ller, H., & Golenhofen, K. (1989) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580991 · Cited by 47 · see citing works
The Interdigestive Migrating Complex and its Significance in Man
Itoh, Z., AIZAWA, I., & Sekiguchi, T. (1982) · Clinics in Gastroenterology · doi:10.1016/s0300-5089(21)00542-3 · Cited by 47 · see citing works
Stimulating action of KW‐5139 (Leu13‐motilin) on gastrointestinal motility in the rabbit
Kitazawa, T., Ichikawa, S., Yokoyama, T., Ishii, A., & Shuto, K. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14058.x · Cited by 44 · see citing works
Self-citationIshida, Y., Sakahara, S., Tsutsui, C., Kaiya, H., Sakata, I., Oda, S., & Sakai, T. (2009) · Peptides · doi:10.1016/j.peptides.2009.01.006 · Cited by 42 · see citing works
Self-citationInterdigestive migrating contractions are coregulated by ghrelin and motilin in conscious dogs
Ogawa, A., Mochiki, E., Yanai, M., Morita, H., Toyomasu, Y., Ogata, K., Ohno, T., Asao, T., & Kuwano, H. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00078.2011 · Cited by 42 · see citing works
Satoh, T., Inatomi, N., Satoh, H., Marui, S., Itoh, Z., & Ōmura, S. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12762-6 · Cited by 42 · see citing works
Kitazawa, T., Maeda, Y., & Kaiya, H. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.07.005 · Cited by 41 · see citing works
Self-citationErythromycin inhibits contractions of nerve-muscle preparations of the guinea pig small intestine.
Minocha, A., & Galligan, J. J. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24792-9 · Cited by 40 · see citing works
Sakahara, S., Xie, Z., Koike, K., Hoshino, S., Sakata, I., Oda, S., Takahashi, T., & Sakai, T. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00278.2010 · Cited by 39 · see citing works
Molecular identification of GHS-R and GPR38 in Suncus murinus
Suzuki, A., Ishida, Y., Aizawa, S., Sakata, I., Tsutsui, C., Mondal, A., Kanako, K., & Sakai, T. (2012) · Peptides · doi:10.1016/j.peptides.2012.04.019 · Cited by 38 · see citing works
Deloose, E., Vos, R. D., Janssen, P., den Bergh, O. V., Oudenhove, L. V., Depoortere, I., & Tack, J. F. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.113456 · Cited by 38 · see citing works
Shafton, A. D., Sanger, G. J., Witherington, J. J., Brown, J. D., Muir, A., Butler, S., Abberley, L., Shimizu, Y., & Furness, J. B. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01176.x · Cited by 37 · see citing works
Primary structure, tissue distribution, and biological activity of chicken motilin receptor
YAMAMOTO, I., Kaiya, H., Tsutsui, C., Sakai, T., Tsukada, A., Miyazato, M., & Tanaka, M. (2008) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2008.03.007 · Cited by 36 · see citing works
Self-citationKitazawa, T., Taneike, T., & Ohga, A. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(97)01024-0 · Cited by 36 · see citing works
Self-citationInatomi, N., Sato, F., Marui, S., Itoh, Z., & Ōmura, S. (1996) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.71.29 · Cited by 36 · see citing works
Kitazawa, T., Nakamura, T., Saeki, A., Teraoka, H., Hiraga, T., & Kaiya, H. (2011) · Peptides · doi:10.1016/j.peptides.2011.07.026 · Cited by 35 · see citing works
Self-citationArena, P. C., Richardson, K. C., & Yamada, J. (1990) · Europe PMC (PubMed Central) · Cited by 35 · see citing works
Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans
Falkén, Y., Hellström, P. M., Sanger, G. J., Dewit, O., Dukes, G. E., Grybäck, P., Holst, J. J., & Näslund, E. B. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01463.x · Cited by 34 · see citing works
Ghrelin Is an Essential Factor for Motilin-Induced Gastric Contraction in Suncus murinus
Kuroda, K., Hequing, H., Mondal, A., Yoshimura, M., Ito, K., Mikami, T., Takemi, S., Jogahara, T., Sakata, I., & Sakai, T. (2015) · Endocrinology · doi:10.1210/en.2015-1561 · Cited by 34 · see citing works
Isolation, sequence, and bioactivity of chicken motilin
Clercq, P. D., Depoortere, I., Macielag, M. J., Vandermeers, A., Vandermeers‐Piret, M., & Peeters, T. L. (1996) · Peptides · doi:10.1016/0196-9781(95)02120-5 · Cited by 34 · see citing works
Molecular identification and characterization of the dog motilin receptor
Ohshiro, H., Nonaka, M., & Ichikawa, K. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.08.012 · Cited by 33 · see citing works
Ozaki, K., Onoma, M., Muramatsu, H., Sudo, H., Yoshida, S., Shiokawa, R., Yogo, K., Kamei, K., Cynshi, O., Kuromaru, O., et al. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.059 · Cited by 32 · see citing works
N-Terminal portion of motilin determines its biological activity
Poitras, P., Gagnon, D., & St-Pierre, S. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91605-p · Cited by 32 · see citing works
Nakamura, T., Onaga, T., & Kitazawa, T. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01422.x · Cited by 31 · see citing works
Self-citationIdentification and expression of the motilin precursor in the guinea pig
Xu, L., Depoortere, I., Tang, M., & Peeters, T. L. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02125-1 · Cited by 29 · see citing works
Kaiya, H., Sakata, I., Yamamoto, K., Koda, A., Sakai, T., Kangawa, K., & Kikuyama, S. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2006.03.008 · Cited by 28 · see citing works
Self-citationBlanco, A. M., Bertucci, J. I., Sánchez‐Bretaño, A., Delgado, M. J., Valenciano, A. I., & Unniappan, S. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.027 · Cited by 28 · see citing works
Demonstration and characterization of motilin-binding sites in the rabbit cerebellum
Depoortere, I., & Peeters, T. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.5.g994 · Cited by 27 · see citing works
Association between plasma ghrelin and motilin levels during MMC cycle in conscious dogs
Zietlow, A. M., Nakajima, H., Taniguchi, H., Ludwig, K., & Takahashi, T. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.05.006 · Cited by 26 · see citing works
Ghrelin as a target for gastrointestinal motility disorders
Meerveld, B. G., Kriegsman, M., & Nelson, R. (2011) · Peptides · doi:10.1016/j.peptides.2011.03.014 · Cited by 26 · see citing works
Demonstration of a functional motilin receptor in TE671 cells from human cerebellum
Thielemans, L. A., Depoortere, I., Assche, G. V., Bender, E., & Peeters, T. L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02055-8 · Cited by 26 · see citing works
Myenteric neural network activated by motilin in the stomach of Suncus murinus (house musk shrew)
Mondal, A., Kawamoto, Y., Yanaka, T., Tsutsui, C., Sakata, I., Oda, S., Tanaka, T., & Sakai, T. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01801.x · Cited by 25 · see citing works
The Prokinetic Face of Ghrelin
Sallam, H. S., & Chen, J. D. Z. (2010) · International Journal of Peptides · doi:10.1155/2010/493614 · Cited by 25 · see citing works
Kitazawa, T., Ishii, A., & Taniyama, K. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13536.x · Cited by 25 · see citing works
Self-citationGhrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro
Kitazawa, T., Itoh, K., Yaosaka, N., Maruyama, K., Matsuda, K., Teraoka, H., & Kaiya, H. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.06.025 · Cited by 24 · see citing works
Self-citationOrigin and characterization of migrating myoelectric complex in rabbits
Ruckebusch, Y., Pairet, M., & Becht, J. L. (1985) · Digestive Diseases and Sciences · doi:10.1007/bf01320488 · Cited by 23 · see citing works
Kitazawa, T., Yoshida, A., Tamano, T., Teraoka, H., & Kaiya, H. (2013) · Peptides · doi:10.1016/j.peptides.2013.02.012 · Cited by 23 · see citing works
Self-citationYoshimura, Y., Nagano, K., Subedi, K., & Kaiya, H. (2005) · The Journal of Poultry Science · doi:10.2141/jpsa.42.291 · Cited by 22 · see citing works
Self-citationImmunocytochemical localization of motilin-containing cells in the rabbit gastrointestinal tract
Satoh, M., Sakai, T., Koyama, H., Shiba, Y., & Itoh, Z. (1995) · Peptides · doi:10.1016/0196-9781(95)00046-m · Cited by 21 · see citing works
Neurohumoral control of gastrointestinal motility
Rozé, C. (1980) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19800701 · Cited by 19 · see citing works
Stimulatory effect of ghrelin on food intake in bullfrog larvae
Shimizu, S., Kaiya, H., & Matsuda, K. (2013) · Peptides · doi:10.1016/j.peptides.2013.10.028 · Cited by 19 · see citing works
Self-citationIdentification and characterization of a motilin-like peptide and its receptor in teleost
Liu, Y., Li, S., Huang, X., Lu, D., Liu, X., Ko, W. H., Zhang, Y., Cheng, C. H. K., & Lin, H. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.02.018 · Cited by 19 · see citing works
Mediators and enteric nerve pathways controlling gastric emptying
Daniel, E. E., Tougas, G. H., Allescher, H., Vergara, P., & Fox-Threlkeld, J.-A. E. T. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02300374 · Cited by 18 · see citing works
Kitazawa, T., Shimazaki, M., Kikuta, A., Yaosaka, N., Teraoka, H., & Kaiya, H. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.12.013 · Cited by 18 · see citing works
Self-citationPan, Q., & Fang, Z. (1993) · Cell Transplantation · doi:10.1177/096368979300200510 · Cited by 18 · see citing works
Structural determination, distribution, and physiological actions of ghrelin in the guinea pig
Okuhara, Y., Kaiya, H., Teraoka, H., & Kitazawa, T. (2017) · Peptides · doi:10.1016/j.peptides.2017.11.010 · Cited by 17 · see citing works
Self-citationExcitatory action of [Leu13]motilin on the gastrointestinal smooth muscle isolated from the chicken
Kitazawa, T., Taneike, T., & Ohga, A. (1995) · Peptides · doi:10.1016/0196-9781(95)00095-2 · Cited by 17 · see citing works
Self-citationApu, A. S., Mondal, A., Kitazawa, T., Takemi, S., Sakai, T., & Sakata, I. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.05.017 · Cited by 17 · see citing works
Self-citationRhythmic oscillating complexes in gastrointestinal tract of chickens: a role for motilin
Rodríguez‐Sinovas, A., Jiménez, M., Clercq, P. D., Peeters, T., & Vergara, P. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.4.g916 · Cited by 17 · see citing works
Characterization of ghrelin‐sensitive neurons in the lumbosacral defecation center in rats
Naitou, K., Shiina, T., Sugita, R., Nakamori, H., & Shimizu, Y. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12492 · Cited by 16 · see citing works
Kitazawa, T., Yoshida, M., Teraoka, H., & Kaiya, H. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.02.014 · Cited by 15 · see citing works
Self-citationRhythmic oscillating complex: characterization, induction, and relationship to MMC in chickens
Jiménez, M., Martı́nez, V., Rodriguez-Membrilla, A., Rodríguez‐Sinovas, A., Goñalons, E., & Vergara, P. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.266.4.g585 · Cited by 14 · see citing works
Kitazawa, T., Hiraga, T., Teraoka, H., Yaosaka, N., & Kaiya, H. (2014) · Peptides · doi:10.1016/j.peptides.2014.11.006 · Cited by 11 · see citing works
Self-citationKitazawa, T., Kikui, S., Taneike, T., & Ohaga, A. (1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)02039-x · Cited by 11 · see citing works
Self-citationMartı́nez, V., Jiménez, M., Goñalons, E., & Vergara, P. (1995) · Poultry Science · doi:10.3382/ps.0740563 · Cited by 10 · see citing works
Effects of CCK‐receptor antagonist on colonic motor activity in dogs
Karaus, M., & Niederau, C. (1995) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.1995.tb00210.x · Cited by 9 · see citing works
Kitazawa, T., Teraoka, H., & Kaiya, H. (2017) · Endocrine Journal · doi:10.1507/endocrj.64.s5 · Cited by 7 · see citing works
Self-citationKitazawa, T., Harada, R., Sakata, I., Sakai, T., & Kaiya, H. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.01.010 · Cited by 7 · see citing works
Self-citationCurrent knowledge of ghrelin in amphibians
Kaiya, H., Kangawa, K., & Miyazato, M. (2017) · Endocrine Journal · doi:10.1507/endocrj.64.s15 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
1 of the 151 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The immunology of Parkinson’s disease
Zhu, B., Yin, D., Zhao, H., & Zhang, L. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00947-3 · Cited by 102 · see citing works
Richards, P., Thornberry, N. A., & Pinto, S. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101175 · Cited by 88 · see citing works
Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility
Kitazawa, T., & Kaiya, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.700884 · Cited by 62 · see citing works
Self-citationMa, P., Peng, Y., Zhao, L., Liu, F., & Li, X. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153790 · Cited by 61 · see citing works
Khan, M. T., Zohair, M., Khan, A., Kashif, A., Mumtaz, S., & Muskan, F. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112599 · Cited by 59 · see citing works
Large-scale snake genome analyses provide insights into vertebrate development
Peng, C., Wu, D., Ren, J., Peng, Z., Ma, Z., Wu, W., Lv, Y., Wang, Z., Deng, C., Jiang, K., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.030 · Cited by 43 · see citing works
Zhang, J., & HongHua, W. (2019) · PubMed Central · Cited by 37 · see citing works
Forssten, S. D., Ouwehand, A. C., Griffin, S. M., & Patterson, E. (2022) · Nutrients · doi:10.3390/nu14030568 · Cited by 39 · see citing works
The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond
Perelló, M., Cornejo, M. P., Francesco, P. N. D., Fernández, G., Gautron, L., & Valdivia, L. S. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.03.003 · Cited by 32 · see citing works
Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis
Gajewska, A., Strzelecki, D., & Gawlik-Kotelnicka, O. (2023) · Nutrients · doi:10.3390/nu15183960 · Cited by 27 · see citing works
Lycopene Aggravates Acute Gastric Injury Induced by Ethanol
Chen, X., Zhao, Y., Liu, K., Li, Z., Tan, X., Wang, Y., Gao, N., Liu, C., Fang, X., & Wang, Y. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.697879 · Cited by 29 · see citing works
Simulated gastrointestinal digestion of walnut protein yields anti-inflammatory peptides
Xia, W., Gao, Y., Fang, X., Jin, L., Liu, R., Wang, L.-S., Deng, Y., Gao, J., Yang, H., Wu, W., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.138646 · Cited by 28 · see citing works
Gastric ghrelin cells in obese patients are hyperactive
Castorina, S., Barresi, V., Luca, T., Privitera, G., Geronimo, V. D., Lezoche, G., Cosentini, I., Vincenzo, A. D., Barbatelli, G., Giordano, A., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00711-3 · Cited by 28 · see citing works
Ali, B. H., Za’abi, M. A., Suleimani, Y. M. A., Manoj, P., Ali, H. A., Ribeiro, D. A., & Nemmar, A. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01844-y · Cited by 27 · see citing works
Yang, B., Li, K., Niu, M., Wei, J., Zhao, S., Jia, C., & Xu, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132905 · Cited by 25 · see citing works
Campo, A., Dufour, S., & Rousseau, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1056939 · Cited by 23 · see citing works
Zhang, S., Okuhara, Y., Iijima, M., Takemi, S., Sakata, I., Kaiya, H., Teraoka, H., & Kitazawa, T. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113294 · Cited by 21 · see citing works
Self-citationHamel, J. F., Sabbagh, C., Alvès, A., Regimbeau, J. M., Vignaud, T., & Venara, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-86699-w · Cited by 20 · see citing works
Minding the gut: extending embodied cognition and perception to the gut complex
Boem, F., Greslehner, G. P., Konsman, J. P., & Chiu, L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1172783 · Cited by 17 · see citing works
Zheng, X., Chen, Z., Zhuang, W., Zhang, J., He, J., Xie, Y., & Chen, J. (2022) · Animals · doi:10.3390/ani12243496 · Cited by 16 · see citing works
Zhang, Q., Huang, L., Leng, B. S., Li, Y., Jiao, N., Jiang, S., Yang, W., & Yuan, X. (2021) · Toxins · doi:10.3390/toxins13100736 · Cited by 16 · see citing works
Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis
Zhang, Y., Zhang, Y., Li, M., Tian, J., & Tong, X. (2024) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm23100 · Cited by 13 · see citing works
Ji, X., Qiao, Y., Zheng, W., Jiang, H., & Yao, W. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112656 · Cited by 13 · see citing works
Zhang, M., Gui-zhi, W., Zhang, J., & Chang-qin, H. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116529 · Cited by 13 · see citing works
Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04227-x · Cited by 11 · see citing works
“In addition, ginger may raise circulating concentrations of ghrelin, which stimulates GI motility in mammals [39, 40].”
BackgroundMaltodextrin alleviates constipation induced by loperamide hydrochloride in mice
Zhen, Y., Chen, Q., Ren, Y., Shi, J., Xu, Z., Xue, Y., & Geng, Y. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105675 · Cited by 11 · see citing works
Grape seed powder increases gastrointestinal motility
Choi, N.-R., Kim, J., Kwon, M., Lee, J.-R., Kim, S. C., Lee, M. J., Choi, W., & Kim, B. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.72529 · Cited by 11 · see citing works
Akinmurele, O. J., Sonibare, M. A., Elujoba, A. A., Ogunlakin, A. D., Yeye, E. O., Gyebi, G. A., Ojo, O. A., & Alanzi, A. R. (2023) · Molecules · doi:10.3390/molecules28207069 · Cited by 11 · see citing works
Zhang, S., Teraoka, H., Kaiya, H., & Kitazawa, T. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113649 · Cited by 11 · see citing works
Self-citationScrabbling the Nutraceutical Potential of Berries in Gastrointestinal Disorders: A Review
Rakha, A., Rasheed, H., Rabail, R., Muntaha, S. T., Fatima, I., Noreen, R., & Aadil, R. M. (2023) · Food Reviews International · doi:10.1080/87559129.2023.2224427 · Cited by 10 · see citing works
Dietary Stimuli, Intestinal Bacteria and Peptide Hormones Regulate Female Drosophila Defecation Rate
Kotronarou, K., Charalambous, A., Evangelou, A., Georgiou, O., Demetriou, A., & Apidianakis, Y. (2023) · Metabolites · doi:10.3390/metabo13020264 · Cited by 10 · see citing works
Zhang, W., Wang, X., Yin, S., Wang, Y., Li, Y., & Ding, Y. (2024) · European Journal of Nutrition · doi:10.1007/s00394-024-03401-2 · Cited by 9 · see citing works
Moreira, G. M., Aguiar, G. L., Meneses, J. A. M., Nascimento, K. B., Ramírez-Zamudio, G. D., Costa, T. C., Duarte, M. D. S., Casagrande, D. R., & Gionbelli, M. P. (2024) · Journal of Animal Science · doi:10.1093/jas/skae328 · Cited by 9 · see citing works
Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen
Ontai, A., Hamchand, R., Crawford, J. M., & Goodman, A. L. (2023) · mBio · doi:10.1128/mbio.01907-23 · Cited by 8 · see citing works
Chen, S., Zhu, L.-J., Zhi, Y., Wu, H.-S., Li, L.-Z., Li, B., Shen, S., Lv, G., & Wang, K.-G. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207325666220827152654 · Cited by 8 · see citing works
Álvarez, C., Alvarado, J. F., Farías, M., Cárcamo, C. B., Flores, H., Guzmán, F., Martín, S. S., Varas, J., Messina, S., Acosta, F., et al. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739468 · Cited by 8 · see citing works
Neto, J. A. D. O. N., Yariwake, V. Y., Câmara, N. O. S., & Andrade‐Oliveira, V. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1248757 · Cited by 6 · see citing works
Revealing the biological features of the axolotl pancreas as a new research model
Ma, H., Peng, G., Hu, Y., Lu, B., Zheng, Y., Wu, Y., Feng, W., Shi, Y., Pan, X., Li, S., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1531903 · Cited by 6 · see citing works
Jalleh, R. J., Wu, T., Umapathysivam, M. M., Young, R. L., Jones, K. L., Marathe, C. S., Rayner, C. K., Plummer, M. P., & Horowitz, M. (2026) · Physiological Reviews · doi:10.1152/physrev.00009.2025 · Cited by 6 · see citing works
Mocanu, V. (2020) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2020.298 · Cited by 6 · see citing works
Kaneoke, Y., Donishi, T., & Terada, M. (2020) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2020.10.012 · Cited by 5 · see citing works
Zhang, S., Kaiya, H., & Kitazawa, T. (2022) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2022.114140 · Cited by 5 · see citing works
Self-citationRabahi, S., Maurin, L., Marachlian, E., Guendel, F., Mikdache, A., Quintero-Castillo, K., Donato, V. D., Riou-Ramon, J., Kurup, A. J., Salloum, Y., et al. (2026) · Science · doi:10.1126/science.adr1707 · Cited by 4 · see citing works
Zhang, S., Kaiya, H., Teraoka, H., & Kitazawa, T. (2021) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2021.113897 · Cited by 4 · see citing works
Self-citationGoudsward, H. J., Ruiz-Velasco, V., Stella, S., Herold, P. B., & Holmes, G. M. (2024) · Molecular Pharmacology · doi:10.1124/molpharm.124.000957 · Cited by 4 · see citing works
Identification of Motilin in Japanese Fire Bellied NewtPreprint
Matsumoto, M., Takemi, S., Sakai, T., & Sakata, I. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4019826 · Cited by 4 · see citing works
Chong, J., Zhou, Y., Li, Z., Li, X., Zhang, J., Cao, H., Ma, J., Ge, L., Zhong, H., & Sun, J. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1610956 · Cited by 3 · see citing works
Loganathan, T., Dyke, J., & Volkoff, H. (2025) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2025.111935 · Cited by 3 · see citing works
Azuma, M., Konno, N., Sakata, I., Koshimizu, T., & Kaiya, H. (2024) · Cell and Tissue Research · doi:10.1007/s00441-024-03896-5 · Cited by 3 · see citing works
Self-citationRomash, I. B. (2019) · Mental Health Global Challenges Journal · doi:10.32437/mhgcj-2019(0).70 · Cited by 3 · see citing works
The role of ghrelin in normal and pathological conditions
Щербак, В. А., Ishchenko, N. A., Михайловна, Щ. Н., & Ta, A. (2023) · Medical news of the North Caucasus · doi:10.14300/mnnc.2023.18099 · Cited by 2 · see citing works
Lozano‐Villegas, K. J., Herrera‐Sánchez, M. P., Rondón‐Barragán, I. S., & Rodríguez‐Hernández, R. (2025) · Animals · doi:10.3390/ani15213127 · Cited by 2 · see citing works
Shree, D., Patra, C. N., & Sahoo, B. M. (2022) · Nanoscience & Nanotechnology-Asia · doi:10.2174/2210681212666220707141136 · Cited by 2 · see citing works
The Intervening Touch of Mentality: Food Seeking in Frogs and Whitehead’s Philosophy of Organism
Miller, G. L. (2021) · Process Studies · doi:10.5406/processstudies.50.2.0155 · Cited by 2 · see citing works
Hu, J., Zhang, Y., Zheng, S., Chen, G.-R., Lin, Y., Kang, D., Lin, Z., & Yao, P. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.05.070 · Cited by 2 · see citing works
Galligan, T. M., Temkin, A. M., & Hale, M. D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824464-7.00010-6 · Cited by 2 · see citing works
Ngernsoungnern, P., Rungsawang, P., Janthaweera, A., Duangsuwan, P., Saowakon, N., Sritangos, P., & Ngernsoungnern, A. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102348 · Cited by 2 · see citing works
Shen, Q., Zhu, Y., Xu, W., Tang, M., Xie, H., Chen, J. D. Z., & Wu, G. (2024) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2024.06.503 · Cited by 2 · see citing works
Ige, A. O., Ayoola, O. I., Oladejo, E., Adele, B. O., Ola, O. O., & Adewoye, E. O. (2021) · Research Journal of Health Sciences · doi:10.4314/rejhs.v10i1.4 · Cited by 2 · see citing works
Effect of laser acupuncture on adhesive small bowel obstruction
Shih, C.-H., Hsieh, T.-M., Wu, B.-Y., & Liu, C. (2021) · Medicine · doi:10.1097/md.0000000000025035 · Cited by 2 · see citing works
Yang, L., Li, H., Jin, Y. H., He, Y., Mei, L., & Jin, C. (2021) · Peptides · doi:10.1016/j.peptides.2021.170574 · Cited by 2 · see citing works
Hormonal control of the digestive system
Jönsson, E., & Olsson, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90801-6.00074-4 · Cited by 2 · see citing works
Osadchuk, M. A., Mironova, E. D., & Kireeva, N. V. (2024) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-217-9-68-74 · Cited by 1 · see citing works
Effect of fractal quality of Indian classical music on autonomic function
Sanyal, P., Roy, K., Chakrabarty, S., Chandran, D. S., & Deepak, K. K. (2024) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2024.106242 · Cited by 1 · see citing works
Physiological roles of ghrelin in the regulation of gastrointestinal motility in vertebrates
Zhang, S., Kaiya, H., & Kitazawa, T. (2025) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2025.114698 · Cited by 1 · see citing works
Self-citationOverviews of avian neuropeptides and peptides
Wang, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819770-7.00046-3 · Cited by 1 · see citing works
Romash, I. B., Mishchuk, V. G., Romash, I. R., Krasilych, I., Romash, N. I., Вус, В., & Kolinko, Y. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202202103 · Cited by 1 · see citing works
Molecular cloning and analysis of the ghrelin/GHSR system in Xenopus tropicalis
Wada, R., Takemi, S., Matsumoto, M., Iijima, M., Sakai, T., & Sakata, I. (2022) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2022.114167 · Cited by 1 · see citing works
Zhang, S., Kaiya, H., & Kitazawa, T. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114384 · Cited by 1 · see citing works
Self-citationJose, S. P., Ratheesh, M., Sreevallabhan, S., Rajan, S., Krishnakumar, I. M., & Sukumaran, S. (2024) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2024.100117 · Cited by 1 · see citing works
The sui generis gut of the hagfish: a focal point of hagfish physiology
Weinrauch, A. M., & Glover, C. N. (2025) · Journal of Experimental Biology · doi:10.1242/jeb.249851 · Cited by 1 · see citing works
The Physiology and Pharmacology of Diabetic Gastropathy Management
Dolan, R. D., Rohani, T. S., Muttineni, D., & Mashimo, H. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00045-1 · Cited by 1 · see citing works
Li, H., Yang, L., Jin, Y. H., & Jin, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.770430 · Cited by 1 · see citing works
Choi, N. R., Kim, J. N., Lee, M., & Kim, B. J. (2022) · Applied Sciences · doi:10.3390/app12094175 · Cited by 1 · see citing works
Maternal, Fetal, and Neonatal Nutrition Has Lifelong Implications
Maheshwari, A., & Swanson, J. R. (2022) · Clinics in Perinatology · doi:10.1016/j.clp.2022.03.001
Raimundo, E. K. D. M., de Carvalho, L. C., Sousa, M., Veras, A. G., Lima, M., Amoroso, L., Artoni, S., & da Silva, E. P. (2023) · Brazilian Journal of Poultry Science · doi:10.1590/1806-9061-2022-1705
Ritchison, G. (2023) · Fascinating life sciences · doi:10.1007/978-3-031-14852-1_8
Al-Hayder, M. N., Neamah, N. F., & Abed, R. I. (2023) · AIP conference proceedings · doi:10.1063/5.0162045
Oliinyk, T. M., Rozova, K. V., Kovalchuk, O. I., Raskaliei, T. Y., Раскалєй, В. Б., & Khmelnytska, Y. K. (2023) · Bulletin of Problems Biology and Medicine · doi:10.29254/2077-4214-2023-4-171-42-47
Case Report: Toxic megacolon secondary to chronic constipation and cocaine consumption
Dimas, B., Hernández, G., Peralta, I., Godínez-Vidal, A. R., Gutiérrez, G., & Cruz, F. (2024) · Frontiers in Surgery · doi:10.3389/fsurg.2024.1434523
Heard, J. C., Ilanga, M. A. P., & Cho, E. (2025) · Springer eBooks · doi:10.1007/978-3-031-78409-5_1
Rabahi, S., Marachlian, E., Guendel, F., Mikdache, A., Quintero-Castillo, K., Maurin, L., Donato, V. D., Kurup, A. J., Salloum, Y., Gros, G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.25.650580
Scanes, C. G., Jaszcza, K., & Pierzchała, K. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1553474
Intrinsic factors with sanogenic impact on the digestion process in the small intestine
Şeptiţchi, V., & Leorda, A. (2025) · Integrare prin cercetare și inovare. Științe exacte și ale naturii · doi:10.59295/spd2024n.48
Al-Beltagi, M., Saeed, N., Bediwy, A., & Elbeltagi, R. (2025) · World Journal of Methodology · doi:10.5662/wjm.v15.i4.102408
Feher, J. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-820476-4.00069-2
Jiang, W.-L., Hu, X.-Y., Zheng, H.-X., Nan, M.-H., Li-zhe, L., Tian-xu, W., Li, J.-L., & Bai, C.-C. (2026) · World Journal of Diabetes · doi:10.4239/wjd.v17.i3.119126
Zhai, P. C., Xu, D.-C., Guo, Y., & Zhang, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1701847
Microbial-derived mediators of the gut–brain axis: Implications for neurological disorders
Abady, M. M., Shawky, A. M., & Mohammed, D. M. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110394
Comprehensive Analysis of miRNAs, mRNAs, and lncRNAs in Intestines of Breast‐ and Formula‐Fed Pigs
Huang, Y., Xu, L., Huang, Y., Yan, Q., He, H., & Zhang, J. (2026) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.70072
İnan, C. M., Duman, E., Canbolat, E., BOZDAĞ, A. N. S., & Çapraz, M. (2026) · BMC Gastroenterology · doi:10.1186/s12876-026-05062-3
- Authors
- Kitazawa, T., & Kaiya, H.
- Affiliations
- Rakuno Gakuen University (JP)
- National Cerebral and Cardiovascular Center Research Institute (JP)
- Corresponding author
- Kitazawa, Takio
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-17
- Volume
- 10
- Pages
- 278-278
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6533539
- OpenAlex
- W2946699235
- Cited by
- 91
- References
- 151
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 15 · 2023: 19 · 2022: 14 · 2021: 15 · 2020: 5 · 2019: 3
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (23570081, 26440174, 26440169)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gastrointestinal motility, motilin, ghrelin, energy homeostasis, GHS-R1a, postprandial motility, smooth muscle contractility, appetite regulation, phylogenetic distribution, fish, birds, mammals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
