Editorial: Developmental Programming of Metabolic Diseases
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Many chronic diseases share a similar pathogenesis involving the interaction of genetic and environmental factors.
“Many of these chronic diseases share a similar pathogenesis involving the interaction of genetic and environmental factors [4,5,6].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [5]
The editorial states that genetic predisposition and environmental exposures are important factors in chronic disease and discusses mechanisms relevant to several metabolic diseases (Editorial: Developmental Programming of Metabolic Diseases; page not provided). It does not establish that these diseases share a similar pathogenesis specifically involving an interaction between genetic and environmental factors. (LLM, conf=0.82)
Experimental — accuracy not yet measuredMultiple lines of evidence support the maladaptive response of human populations to rapidly changing nutritional, physical, psychological and cultural environments in the modern world.
“Multiple lines of evidence support the maladaptive response of human populations to rapidly changing nutritional, physical, psychological and cultural environments, in the modern world [5,11,14,75].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [5]
The editorial’s main text (page unavailable) reports that maternal nutritional and other early-life environmental exposures can adversely affect offspring metabolic health. It does not address rapidly changing modern environments or establish maladaptive responses across human populations to physical, psychological, and cultural changes. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe susceptibility alleles may be activated or functionally enhanced by a range of maternal and environmental factors.
“In addition, the susceptibility alleles may be “activated” or “functionally enhanced” by a range of maternal and environmental factors, as is usually presumed to be the case in PCOS [5,14,102].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [5]
The editorial says genetic predisposition and maternal or environmental exposures are important to chronic disease risk, and that in utero exposures can perturb fetal metabolic programming (Editorial: Developmental Programming of Metabolic Diseases; page not provided). It does not say that those exposures activate or enhance susceptibility alleles, or discuss that mechanism in PCOS. (LLM, conf=0.83)
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Cites
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Self-citationMouse Models of Diabetes, Obesity and Related Kidney Disease
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Self-citationMaternal obesity increases the risk of metabolic disease and impacts renal health in offspring
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Self-citationMetformin and Fibrosis: A Review of Existing Evidence and Mechanisms
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Self-citationEffect of GLP-1 Receptor Activation on Offspring Kidney Health in a Rat Model of Maternal Obesity
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Prenatal Programming of Insulin Secretion in Intrauterine Growth Restriction
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Self-citationThe renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet
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Self-citationKCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease
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Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113 · see citing works
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
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Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · BMC Biology · doi:10.1186/s12915-024-01926-w · Cited by 8 · see citing works
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Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · Figshare · doi:10.6084/m9.figshare.26727835
- Authors
- Glastras, S. J., Valvi, D., & Bansal, A.
- Affiliations
- The University of Sydney (AU)
- Icahn School of Medicine at Mount Sinai (US)
- Australian National University (AU)
- Corresponding author
- Valvi, Damaskini
- Bansal, Amita
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2021-10-21
- Volume
- 12
- Pages
- 781361-781361
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC8566724
- OpenAlex
- W3206513536
- Cited by
- 5
- References
- 22
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 1
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- developmental programming, metabolic disorders, fetal origins of disease
- MeSH terms
- Animals, Child Development, Environmental Exposure, Female, Humans, Infant, Newborn, Metabolic Diseases, Pregnancy, Prenatal Exposure Delayed Effects
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