Cited by 152Effects and risks of endocrine disrupting chemicalsAdipokines, Inflammation, and Metabolic DiseasesImmunotoxicology and immune responses

Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health

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Bansal, Amita, Henao-Mejia, Jorge, Simmons, Rebecca A·2018·Endocrinology

Abstract

The incidence of metabolic disorders like type 2 diabetes and obesity continues to increase. In addition to the well-known contributors to these disorders, such as food intake and sedentary lifestyle, recent research in the exposure science discipline provides evidence that exposure to endocrine-disrupting chemicals like bisphenol A and phthalates via multiple routes (e.g., food, drink, skin contact) also contribute to the increased risk of metabolic disorders. Endocrine-disrupting chemicals (EDCs) can disrupt any aspect of hormone action. It is becoming increasingly clear that EDCs not only affect endocrine function but also adversely affect immune system function. In this review, we focus on human, animal, and in vitro studies that demonstrate EDC exposure induces dysfunction of the immune system, which, in turn, has detrimental effects on metabolic health. These findings highlight how the immune system is emerging as a novel player by which EDCs may mediate their effects on metabolic health. We also discuss studies highlighting mechanisms by which EDCs affect the immune system. Finally, we consider that a better understanding of the immunomodulatory roles of EDCs will provide clues to enhance metabolic function and contribute toward the long-term goal of reducing the burden of environmentally induced diabetes and obesity.

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Crossref · 10.1210/en.2017-00882

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  • There is accumulating evidence from human and animal studies that shows associations between exposure to organic pollutants and other widely diffused toxins and an increased risk of metabolic diseases, including obesity.

    “There is accumulating evidence from human and animal studies that shows associations between exposure to organic pollutants and other widely diffused toxins to an increased risk of metabolic diseases, including obesity [104].”

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Authors
Bansal, A., Henao-Mejia, J., & Simmons, R. A.
Affiliations
  • Children's Hospital of Philadelphia (US)
  • Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Corresponding author
  • Bansal, Amita
  • Simmons, Rebecca A
Venue
Endocrinology
Published
2017-11-14
Volume
159
Issue
1
Pages
32-45
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2770607980
Cited by
152
References
131
Citations by year
2026: 12 · 2025: 22 · 2024: 16 · 2023: 19 · 2022: 18 · 2021: 29 · 2020: 19 · 2019: 10 · 2018: 7
FWCI
1.03
Type
journal article
Language
en
Open access
Locations
  • Endocrinology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Environmental Health Sciences (ES023284, ES013508, CEET-ES-013508-05)
  • National Institutes of Health (R21AI128060, R21DK111755, R01HL136572)
  • Pew Charitable Trusts
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
endocrine disruptors, immune dysfunction, immunomodulation, metabolic health, type 2 diabetes, obesity, bisphenol A, phthalates, environmental exposure, metabolic disorders
MeSH terms
Animals, Environmental Exposure, Humans, Immune System, Immune System Diseases, Global Health, Prevalence, Environmental Illness, Health Transition, Endocrine Disruptors

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