The DOI matches its Crossref record; 218 of the 220 references it cites were found in a registry or an index.
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Open accessAbstract
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis incidence increases with age in both post-menopausal women and aging men. Among other important contributing factors to bone fragility observed in osteoporosis, that also affect the elderly population, are metabolic disturbances observed in obesity and Type 2 Diabetes (T2D). These metabolic complications are associated with impaired bone homeostasis and a higher fracture risk. Expansion of the Bone Marrow Adipose Tissue (BMAT), at the expense of decreased bone formation, is thought to be one of the key pathogenic mechanisms underlying osteoporosis and bone fragility in obesity and T2D. Our review provides a summary of mechanisms behind increased Bone Marrow Adiposity (BMA) during aging and highlights the pre-clinical and clinical studies connecting obesity and T2D, to BMA and bone fragility in aging osteoporotic women and men.
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“As aging-related osteoporosis typically features low bone mass, microarchitectural alterations and bone marrow adipose tissue expansion40–42, our findings suggest that AD mice at a younger age recapitulate an aged skeletal phenotype.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [40]
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Flagged first, then by citations
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Research works printed but not linked: 4
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Cited by
Sorted by citations
Links among Obesity, Type 2 Diabetes Mellitus, and Osteoporosis: Bone as a Target
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Endocrinal metabolic regulation on the skeletal system in post-menopausal women
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Background
Metadata
- Authors
- Ali, D., Tencerova, M., Figeac, F., Kassem, M., & Jafari, A.
- Affiliations
- University of Southern Denmark (DK)
- University of Copenhagen (DK)
- Corresponding author
- Ali, Dalia
- Jafari, Abbas
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2022-09-15
- Volume
- 13
- Pages
- 981487-981487
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC9520254
- OpenAlex
- W4295942629
- Cited by
- 122
- References
- 220
- Citations by year
- 2026: 25 · 2025: 42 · 2024: 43 · 2023: 10 · 2022: 2
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- Funders
- Olav Thon Stiftelsen
- Grantová Agentura České Republiky
- Novo Nordisk Fonden
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- osteoporosis, bone marrow adipose tissue, bone marrow adiposity, obesity, type 2 diabetes, aging, bone fragility, bone homeostasis, bone formation, fracture risk, postmenopausal women, older men
- MeSH terms
- Aged, Aging, Bone Marrow, Diabetes Mellitus, Type 2, Female, Humans, Male, Obesity, Osteoporosis, Adiposity, Fractures, Bone
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