Cited by 120Gut microbiota and healthGastrointestinal motility and disordersDiabetes Treatment and Management

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Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease

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Masse, Karly E., Lu, Van B.·2023·Frontiers in Endocrinology

DOI 10.3389/fendo.2023.1169624PMC PMC10407565

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Abstract

The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that can influence chemosensory cells lining the gastrointestinal tract. Specifically, hormone-releasing enteroendocrine cells which express a host of receptors activated by these bacterial metabolites. This review will focus on the activation mechanisms of glucagon-like peptide-1 releasing enteroendocrine cells by the three main bacterial metabolites produced in the gut: short-chain fatty acids, secondary bile acids and indoles. Given the importance of enteroendocrine cells in regulating glucose homeostasis and food intake, we will also discuss therapies based on these bacterial metabolites used in the treatment of metabolic diseases such as diabetes and obesity. Elucidating the mechanisms gut bacteria can influence cellular function in the host will advance our understanding of this fundamental symbiotic relationship and unlock the potential of harnessing these pathways to improve human health.

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Authors: Masse, K. E., & Lu, V. B.
Affiliations: Western University (CA)
Corresponding author: Lu, Van B.
ORCID: Lu, Van B.
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2023-07-25
Volume: 14
Pages: 1169624-1169624
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2023.1169624
PMC: PMC10407565
OpenAlex: W4385251361
Cited by: 120
References: 272
Citations by year: 2026: 66 · 2025: 23 · 2024: 29 · 2023: 2
FWCI: 3.16
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: short-chain fatty acids, secondary bile acids, indole, gut microbiota metabolites, enteroendocrine cells, glucagon-like peptide-1, glucose homeostasis, food intake regulation, diabetes mellitus, obesity, metabolic disease treatment, gut microbiota, host-microbe symbiosis
MeSH terms: Gastrointestinal Microbiome, Bacteria, Bile Acids and Salts, Fatty Acids, Volatile, Humans, Indoles, Metabolic Diseases, Ecosystem, Enteroendocrine Cells

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Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease

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