Translation-Targeting RiPPs and Where to Find Them
Open accessAbstract
Prokaryotic translation is among the major targets of diverse natural products with antibacterial activity including several classes of clinically relevant antibiotics. In this review, we summarize the information about the structure, biosynthesis, and modes of action of translation inhibiting ribosomally synthesized and post-translationally modified peptides (RiPPs). Azol(in)e-containing RiPPs are known to target translation, and several new compounds inhibiting the ribosome have been characterized recently. We performed a systematic search for biosynthetic gene clusters (BGCs) of azol(in)e-containing RiPPs. This search uncovered several groups of clusters that likely direct the synthesis of novel compounds, some of which may be targeting the ribosome.
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Class IV lanthipeptides are characterized by multiple lanthionine rings and exert strong antimicrobial activity against several Gram-positive bacteria, including Streptococcus spp, Clostridium difficile, and Bacillus spp.
“class IV lanthipeptides are characterized by multiple lanthionine rings and exert strong antimicrobial activity against several Gram-positive bacteria, including Streptococcus spp, Clostridium difficile, and Bacillus spp. [80, 81].”
From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [80]
The Introduction’s Thiopeptides section mentions class I lanthipeptides only in passing; it does not describe class IV lanthipeptides or lanthionine rings. It reports activity against Clostridium difficile for a thiopeptide derivative, not a class IV lanthipeptide. Searches for class IV, lanthionine rings, and the named bacteria found no passage supporting the attributed claim; the indexed copy has no page numbers. (LLM, conf=0.76)
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Agolino, G., Cristofolini, M., Ronsivalle, M. A., Cattivelli, A., Tagliazucchi, D., Caggia, C., Solieri, L., & Randazzo, C. L. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10810-0 · Cited by 1 · see citing works
“In detail, class IV lanthip-eptides are characterized by multiple lanthionine rings and exert strong antimicrobial activity against several Gram-positive bacteria, including Streptococcus spp, Clostridium difficile , and Bacillus spp. [80, 81].”
- Authors
- Travin, D. Y., Bikmetov, D., & Severinov, K.
- Affiliations
- Skolkovo Institute of Science and Technology (RU)
- Russian Academy of Sciences (RU)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Travin, Dmitrii Y.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2020-03-31
- Volume
- 11
- Pages
- 226-226
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC7136475
- OpenAlex
- W3014119863
- Cited by
- 19
- References
- 99
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Russian Science Foundation (19-14-00266)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- ribosomally synthesized and post-translationally modified peptides, protein synthesis inhibition, biosynthetic gene clusters, antibiotic biosynthesis, antibacterial natural products, prokaryotic translation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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