Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Origins and evolution of antibiotic resistance

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Antibiotic resistance is ancient

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Call of the wild: antibiotic resistance genes in natural environments

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Antibiotics for Emerging Pathogens

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The shared antibiotic resistome of soil bacteria and human pathogens

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

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Multidrug-resistance efflux pumps ? not just for resistance

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Aminoglycoside modifying enzymes

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Structures of the Bacterial Ribosome at 3.5 A Resolution

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Structure of the 70S Ribosome Complexed with mRNA and tRNA

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Recognition of Cognate Transfer RNA by the 30 <i>S</i> Ribosomal Subunit

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The Structure of the Eukaryotic Ribosome at 3.0 Å Resolution

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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

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Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

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Update on acquired tetracycline resistance genes

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The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit

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Origins and evolution of antibiotic resistance.

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Bacterial resistance to antibiotics: Enzymatic degradation and modification

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Structure of the A Site of <i>Escherichia coli</i> 16 <i>S</i> Ribosomal RNA Complexed with an Aminoglycoside Antibiotic

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Where will new antibiotics come from?

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Intermediate states in the movement of transfer RNA in the ribosome

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The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics

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Structures of the human and Drosophila 80S ribosome

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The bacterial ribosome as a target for antibiotics

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STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY

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Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3

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The structures of four macrolide antibiotics bound to the large ribosomal subunit.

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Crystal Structure of the Eukaryotic 40 S Ribosomal Subunit in Complex with Initiation Factor 1

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The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome

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Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance

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Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.

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Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

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HOW ANTIBIOTIC-PRODUCING ORGANISMS AVOID SUICIDE

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Spontaneous Intersubunit Rotation in Single Ribosomes

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Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit

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A new understanding of the decoding principle on the ribosome

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Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

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Crystal Structure of the Eukaryotic 60 S Ribosomal Subunit in Complex with Initiation Factor 6

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Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites

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The A-Z of bacterial translation inhibitors

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

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Revisiting the structures of several antibiotics bound to the bacterial ribosome

Bulkley, D., Innis, C. A., Blaha, G., & Steitz, T. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008685107 · Cited by 308 · see citing works

Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit

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An Elongation Factor G-Induced Ribosome Rearrangement Precedes tRNA-mRNA Translocation

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Loss of a conserved 7‐methylguanosine modification in 16S rRNA confers low‐level streptomycin resistance in bacteria

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Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.

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Structural Basis of the Translational Elongation Cycle

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Structural insights into peptide bond formation

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The Site of Action of Oxazolidinone Antibiotics in Living Bacteria and in Human Mitochondria

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Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling

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Antibiotics in the clinical pipeline in 2011

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Structure of a cation-bound multidrug and toxic compound extrusion transporter

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Identification of Two Distinct Hybrid State Intermediates on the Ribosome

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Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

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Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

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Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome

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Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

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Tigecycline Is Modified by the Flavin-Dependent Monooxygenase TetX

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Structural basis for TetM-mediated tetracycline resistance

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Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

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The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome

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Functional, biophysical, and structural bases for antibacterial activity of tigecycline

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Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

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Linezolid, the first oxazolidinone antibacterial agent

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Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

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Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides

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Structure of ratcheted ribosomes with tRNAs in hybrid states

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Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

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Programmed drug‐dependent ribosome stalling

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Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

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Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic

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A steric block in translation caused by the antibiotic spectinomycin.

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Selective Protein Synthesis by Ribosomes with a Drug-Obstructed Exit Tunnel

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Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

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Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)

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The ribosome as a molecular machine: the mechanism of tRNA–mRNA movement in translocation

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Structural basis for hygromycin B inhibition of protein biosynthesis.

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Structures of a Na + -coupled, substrate-bound MATE multidrug transporter

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The antibiotic viomycin traps the ribosome in an intermediate state of translocation

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Coordinated conformational and compositional dynamics drive ribosome translocation

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Catalysis of Ribosomal Translocation by Sparsomycin

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The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation

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Allosteric control of the ribosome by small-molecule antibiotics

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Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

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Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors

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