The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns
Open accessAbstract
Macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage-associated and pathogen-associated molecular patterns. In this review, we cover the discovery and molecular characterization of these C-type lectin receptors, and highlight recent advances in the understanding of their roles in orchestrating the response of the immune system to bacterial and fungal infection, and damaged self. We also discuss the identification and structure-activity relationships of activating ligands, particularly trehalose dimycolate and related mycobacterial glycolipids, which have significant potential in the development of TH1/TH17 vaccination strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For direct recognition of apoptotic material by efferocytes an array of receptors, which mediate tethering and/or engulfment, include CR3 and CR4, CD36, CD91 [low density lipoprotein receptor-related protein (LRP)], and other scavenging receptors (SR-A), vitronectin receptor (αvβ3) and αvβ5integrin as well as Mincle, which also recognizes the M. tuberculosis cell wall lipid TDM (134).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [134]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fitzgerald, M., Hayward, I. P., Thomas, A. C., Campbell, J. H., & CAMPBELL, G. R. (1995) · Cited by 2,552
Signalling through C-type lectin receptors: shaping immune responses
Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,449
The C‐type lectin‐like domain superfamily
Zelensky, A. N., & Gready, J. E. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05031.x · Cited by 1,411
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Ishikawa, E., Ishikawa, T., Morita, Y. S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T., Akira, S., Yoshikai, Y., & Yamasaki, S. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091750 · Cited by 794
Mincle is an ITAM-coupled activating receptor that senses damaged cells
Yamasaki, S., Ishikawa, E., Sakuma, M., Hara, H., Ogata, K., & Saito, T. (2008) · Nature Immunology · doi:10.1038/ni.1651 · Cited by 740
Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E. M., Stenger, S., Andersen, P. L., Ruland, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904013 · Cited by 497
Engineering galactose-binding activity into a C-type mannose-binding protein
Drickamer, K. (1992) · Nature · doi:10.1038/360183a0 · Cited by 477
C-type lectin receptors orchestrate antifungal immunity
Hardison, S. E., & Brown, G. D. (2012) · Nature Immunology · doi:10.1038/ni.2369 · Cited by 460
Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells
Moody, D. B., Reinhold, B. B., Guy, M. R., Beckman, E. M., Frederique, D. E., Furlong, S. T., Ye, S., Reinhold, V. N., Sieling, P. A., Modlin, R. L., et al. (1997) · Science · doi:10.1126/science.278.5336.283 · Cited by 441
Wells, C. A., Salvage-Jones, J., Li, X., Hitchens, K., Butcher, S., Murray, R. Z., Beckhouse, A. G., Lo, Y.-L.-S., Manzanero, S., Cobbold, C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7404 · Cited by 434
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia
Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805177106 · Cited by 425
Werninghaus, K., Babiak, A., Groß, O., Hölscher, C., Dietrich, H., Agger, E. M., Mages, J., Mócsai, A., Schoenen, H., Finger, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081445 · Cited by 319
A Novel LPS-Inducible C-Type Lectin Is a Transcriptional Target of NF-IL6 in Macrophages
Matsumoto, M., Tanaka, T., Kaisho, T., Sanjo, H., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.5039 · Cited by 284
Th17 cytokines and mucosal immunity
Dubin, P. J., & Kolls, J. K. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00703.x · Cited by 276
Ishikawa, T., Itoh, F., Yoshida, S., Saijo, S., Matsuzawa, T., Gonoi, T., Saito, T., Okawa, Y., Shibata, N., Miyamoto, T., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.03.008 · Cited by 247
Wüthrich, M., Deepe, G. S., & Klein, B. S. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074958 · Cited by 234
Miyake, Y., Toyonaga, K., Mori, D., Kakuta, S., Hoshino, Y., Oyamada, A., Yamada, H., Ono, K.-I., Suyama, M., Iwakura, Y., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.010 · Cited by 230
The adaptor molecule CARD9 is essential for tuberculosis control
Dorhoi, A., Desel, C., Yeremeev, V., Pradl, L., Brinkmann, V., Mollenkopf, H., Hanke, K., Groß, O., Ruland, J., & Kaufmann, S. H. E. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20090067 · Cited by 210
Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL
Furukawa, A., Kamishikiryo, J., Mori, D., Toyonaga, K., Okabe, Y., Toji, A., Kanda, R., Miyake, Y., Ose, T., Yamasaki, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312649110 · Cited by 168
Lee, W., Kang, J.-S., Yan, J.-J., Lee, M. S., Jeon, B., Cho, S.-N., & Kim, Y.-J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002614 · Cited by 160
Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity
Wevers, B. A., Kaptein, T. M., Willems, E., Theelen, B., Boekhout, T., Geijtenbeek, T. B. H., & Gringhuis, S. I. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.008 · Cited by 159
Sousa, M. G. T., Reid, D. M., Schweighoffer, E., Tybulewicz, V. L. J., Ruland, J., Langhorne, J., Yamasaki, S., Taylor, P. R., de Almeida, S. R., & Brown, G. D. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.005 · Cited by 150
Lee, R. T., Hsu, T.-L., Huang, S. K., Hsieh, S.-L., Wong, C., & Lee, Y. C. (2010) · Glycobiology · doi:10.1093/glycob/cwq193 · Cited by 149
The Dectin-2 family of C-type lectins in immunity and homeostasis
Graham, L. M., & Brown, G. D. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.010 · Cited by 140
Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle
Feinberg, H., Jégouzo, S. A. F., Rowntree, T. J. W., Guan, Y., Brash, M. A., Taylor, M. E., Weis, W. I., & Drickamer, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497149 · Cited by 137
Flornes, L. M., Bryceson, Y. T., Spurkland, A., Lorentzen, J. C., Dissen, E., & Fossum, S. (2004) · Immunogenetics · doi:10.1007/s00251-004-0714-x · Cited by 128
C-type lectin Mincle is an activating receptor for pathogenic fungus
Yamasaki, S. (2009) · Medical Entomology and Zoology · Cited by 124
Graham, L. M., Gupta, V. V., Schäfer, G., Reid, D. M., Kimberg, M., Dennehy, K. M., Hornsell, W. G., Guler, R., Campanero‐Rhodes, M. A., Palma, A. S., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.384164 · Cited by 121
Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans
Bugarc̀ić, A., Hitchens, K., Beckhouse, A. G., Wells, C. A., Ashman, R. B., & Blanchard, H. (2008) · Glycobiology · doi:10.1093/glycob/cwn046 · Cited by 116
Lobato‐Pascual, A., Saether, P. C., Fossum, S., Dissen, E., & Daws, M. R. (2013) · European Journal of Immunology · doi:10.1002/eji.201343752 · Cited by 113
Mincle is a long sought receptor for mycobacterial cord factor
Matsunaga, I., & Moody, D. B. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20092533 · Cited by 96
Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke
Suzuki, Y., Nakano, Y., Mishiro, K., Takagi, T., Tsuruma, K., Nakamura, M., Yoshimura, S., Shimazawa, M., & Hara, H. (2013) · Scientific Reports · doi:10.1038/srep03177 · Cited by 93
The human C‐type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor
Arce, I., Martínez‐Muñoz, L., Roda‐Navarro, P., & Fernández‐Ruiz, E. (2003) · European Journal of Immunology · doi:10.1002/eji.200324230 · Cited by 87
Hattori, Y., Morita, D., Fujiwara, N., Mori, D., Nakamura, T., Harashima, H., Yamasaki, S., & Sugita, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.566489 · Cited by 87
Mincle is not essential for controlling Mycobacterium tuberculosis infection
Heitmann, L., Schoenen, H., Ehlers, S., Lang, R., & Hölscher, C. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.06.005 · Cited by 84
Cloning of a Novel C-type Lectin Expressed by Murine Macrophages
Balch, S. G., McKnight, A. J., Seldin, M. F., & Gordon, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18656 · Cited by 79
Mincle polarizes human monocyte and neutrophil responses to Candida albicans
Vijayan, D., Radford, K. J., Beckhouse, A. G., Ashman, R. B., & Wells, C. A. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2012.24 · Cited by 72
Lang, R. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00005 · Cited by 69
C-type lectin receptor Clec4d plays a protective role in resolution of Gram-negative pneumonia
Steichen, A. L., Binstock, B. J., Mishra, B. B., & Sharma, J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1212622 · Cited by 67
On One Leg: Trehalose Monoesters Activate Macrophages in a Mincle‐Dependent Manner
Stocker, B. L., Khan, A. A., Chee, S. H., Kamena, F., & Timmer, M. S. M. (2014) · ChemBioChem · doi:10.1002/cbic.201300674 · Cited by 61
Mincle and human B cell function
Kawata, K., Illarionov, P. A., Yang, G., Kenny, T. P., Zhang, W., Tsuda, M., Ando, Y., Leung, P. S. C., Ansari, A. A., & Gershwin, M. E. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.04.004 · Cited by 41
Balch, S. G., Greaves, D. R., Gordon, S., & McKnight, A. J. (2002) · European Journal of Immunogenetics · doi:10.1046/j.1365-2370.2002.00266.x · Cited by 35
The Second Stroke Audit of Catalonia Shows Improvements in Many, but Not all Quality Indicators
Abilleira, S., Ribera, A., Sánchez, E., Tresserras, R., & Gallofré, M. (2012) · International Journal of Stroke · doi:10.1111/j.1747-4949.2011.00638.x · Cited by 32
Rat Macrophage C-Type Lectin Is an Activating Receptor Expressed by Phagocytic Cells
Lobato‐Pascual, A., Saether, P. C., Dahle, M. K., Gaustad, P., Dissen, E., Fossum, S., & Daws, M. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057406 · Cited by 22
Signaling while eating: MCL is coupled with M incle
Yamasaki, S. (2013) · European Journal of Immunology · doi:10.1002/eji.201344131 · Cited by 21
Characterization of the Receptors for Mycobacterial Cord Factor in Guinea Pig
Toyonaga, K., Miyake, Y., & Yamasaki, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088747 · Cited by 12
When PRRs Collide: Mincle Meddles with Dectin and Toll
Rivera, A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.013 · Cited by 7
The immune receptor Mincle mediates ischemic stroke-induced injury
Manzanero, S., Hsieh, Y., Gelderblom, M., Wells, C. A., & Arumugam, T. V. (2012) · International Journal of Stroke · Cited by 3
Oral Presentations in Order of Conference Program
McCann, C., Fogg, L., Purdy, S. C., Talmage, A., & Leão, S. (2012) · International Journal of Stroke · doi:10.1111/j.1747-4930.2012.00907.x · Cited by 1
Flagged first, then by citations
Cited by
Sorted by citations
Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989
Some methods of estimating the inbreeding coefficient.
Li, C. C., & Horvitz, D. G. (1953) · Europe PMC (PubMed Central) · Cited by 559
C-type lectins: their network and roles in pathogen recognition and immunity
Mayer, S., Raulf, M., & Lepenies, B. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1523-7 · Cited by 263
Pathogenic Fungal Infection in the Lung
Li, Z., Lu, G., & Meng, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01524 · Cited by 184
Lee, H.-J., Woo, Y., Hahn, T., Jung, Y. M., & Jung, Y. (2020) · Microorganisms · doi:10.3390/microorganisms8091298 · Cited by 181
Metadata
- Authors
- Richardson, M. B., & Williams, S. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Williams, Spencer J.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014-06-23
- Volume
- 5
- Pages
- 288-288
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4066366
- OpenAlex
- W2005183346
- Cited by
- 138
- References
- 49
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 17 · 2015: 9 · 2014: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Australian Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- Mincle, C-type lectin receptors, pattern recognition receptors, damage-associated molecular patterns, pathogen-associated molecular patterns, trehalose dimycolate, mycobacterial glycolipids, bacterial infection, fungal infection, structure-activity relationship, innate immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
