Cited by 139Immune Response and InflammationImmune responses and vaccinationsImmunotherapy and Immune Responses

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

Open access

Richardson, Mark B., Williams, Spencer J.·2014·Frontiers in Immunology

DOI 10.3389/fimmu.2014.00288PMC PMC4066366

Open this paper in CoChat — free account Open PDF

Abstract

Macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle) comprise part of an extensive repertoire of pattern recognition receptors with the ability to sense damage-associated and pathogen-associated molecular patterns. In this review, we cover the discovery and molecular characterization of these C-type lectin receptors, and highlight recent advances in the understanding of their roles in orchestrating the response of the immune system to bacterial and fungal infection, and damaged self. We also discuss the identification and structure-activity relationships of activating ligands, particularly trehalose dimycolate and related mycobacterial glycolipids, which have significant potential in the development of TH1/TH17 vaccination strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2014.00288

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Immunol. Cell Biol.
Fitzgerald, M., Hayward, I. P., Thomas, A. C., Campbell, J. H., & CAMPBELL, G. R. (1995) · Cited by 2,552
Signalling through C-type lectin receptors: shaping immune responses
Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,449
The C‐type lectin‐like domain superfamily
Zelensky, A. N., & Gready, J. E. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05031.x · Cited by 1,411
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Ishikawa, E., Ishikawa, T., Morita, Y. S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T., Akira, S., Yoshikai, Y., & Yamasaki, S. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091750 · Cited by 794
Mincle is an ITAM-coupled activating receptor that senses damaged cells
Yamasaki, S., Ishikawa, E., Sakuma, M., Hara, H., Ogata, K., & Saito, T. (2008) · Nature Immunology · doi:10.1038/ni.1651 · Cited by 740
Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate
Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E. M., Stenger, S., Andersen, P. L., Ruland, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904013 · Cited by 497
Engineering galactose-binding activity into a C-type mannose-binding protein
Drickamer, K. (1992) · Nature · doi:10.1038/360183a0 · Cited by 477
C-type lectin receptors orchestrate antifungal immunity
Hardison, S. E., & Brown, G. D. (2012) · Nature Immunology · doi:10.1038/ni.2369 · Cited by 460
Structural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells
Moody, D. B., Reinhold, B. B., Guy, M. R., Beckman, E. M., Frederique, D. E., Furlong, S. T., Ye, S., Reinhold, V. N., Sieling, P. A., Modlin, R. L., et al. (1997) · Science · doi:10.1126/science.278.5336.283 · Cited by 441
The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans
Wells, C. A., Salvage-Jones, J., Li, X., Hitchens, K., Butcher, S., Murray, R. Z., Beckhouse, A. G., Lo, Y.-L.-S., Manzanero, S., Cobbold, C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7404 · Cited by 434

Flagged first, then by citations

Show all 49 references

Sorted by citations

Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989
Some methods of estimating the inbreeding coefficient.
Li, C. C., & Horvitz, D. G. (1953) · Europe PMC (PubMed Central) · Cited by 559
C-type lectins: their network and roles in pathogen recognition and immunity
Mayer, S., Raulf, M., & Lepenies, B. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1523-7 · Cited by 263
Pathogenic Fungal Infection in the Lung
Li, Z., Lu, G., & Meng, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01524 · Cited by 184
Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection
Lee, H.-J., Woo, Y., Hahn, T., Jung, Y. M., & Jung, Y. (2020) · Microorganisms · doi:10.3390/microorganisms8091298 · Cited by 181
The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation
Lv, L. L., Tang, P. M., Li, C. J., You, Y. K., Li, J., Huang, X., Ni, J., Feng, M., Liu, B., & Lan, H.-Y. (2016) · Kidney International · doi:10.1016/j.kint.2016.10.020 · Cited by 170
Diabetic retinopathy and dysregulated innate immunity
Xu, H., & Chen, M. (2017) · Vision Research · doi:10.1016/j.visres.2017.04.013 · Cited by 144
The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy
Chaurasia, S. S., Lim, R. R., Parikh, B. H., Wey, Y. S., Tun, S. B. B., Wong, T. Y., Luu, C. D., Agrawal, R. V., Ghosh, A., Mortellaro, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21198-z · Cited by 141
Quercetin protects against cisplatin‐induced acute kidney injury by inhibiting Mincle/Syk/NF‐κB signaling maintained macrophage inflammation
Tan, R., Wang, C., Deng, C., Zhong, X., Yan, Y., Luo, Y., Lan, H., He, T., & Wang, L. (2019) · Phytotherapy Research · doi:10.1002/ptr.6507 · Cited by 125
Curcumin relieved cisplatin-induced kidney inflammation through inhibiting Mincle-maintained M1 macrophage phenotype
Tan, R.-Z., Liu, J., Zhang, Y.-Y., Wang, H.-L., Li, J.-C., Liu, Y.-H., Zhong, X., Zhang, Y.-W., Yan, Y., Lan, H.-Y., et al. (2019) · Phytomedicine · doi:10.1016/j.phymed.2018.09.210 · Cited by 122
The Dietary Flavonoid Kaempferol Mediates Anti‐Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets
Kim, S. H., Park, J. G., Lee, J., Yang, W. S., Park, K. W., Kim, H. G., Yi, Y., Baek, K., Sung, N. Y., Hossen, M. J., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/904142 · Cited by 109
Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages
Fu, Y., & Harrison, R. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662063 · Cited by 118
Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity
Patin, E. C., Orr, S. J., & Schaible, U. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00861 · Cited by 101
Emerging roles of protein mannosylation in inflammation and infection
Loke, I., Kolarich, D., Packer, N. H., & Thaysen‐Andersen, M. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.004 · Cited by 100
Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate
Kostarnoy, A. V., Gancheva, P. G., Lepenies, B., Ильдарович, Т. А., Dzharullaeva, A. S., Polyakov, N. B., Grumov, D. A., Egorova, D. A., Kulibin, A. Y., Bobrov, M. A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611665114 · Cited by 88
Peroxiredoxin 1 aggravates acute kidney injury by promoting inflammation through Mincle/Syk/NF-κB signaling
Li, S., Zhang, Y., Lu, R., Lv, X., Lei, Q., Tang, D., Dai, Q., Deng, Z., Liao, X., Tu, S., et al. (2023) · Kidney International · doi:10.1016/j.kint.2023.04.013 · Cited by 89
Human Lectins, Their Carbohydrate Affinities and Where to Find Them
Raposo, C. D. D. C. B. G., Canelas, A. B., & Barros, M. T. (2021) · Biomolecules · doi:10.3390/biom11020188 · Cited by 82
Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors
Ostrop, J., & Lang, R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601665 · Cited by 85
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease
Magdaleno, F., Blajszczak, C. C., & Nieto, N. (2017) · Biomolecules · doi:10.3390/biom7010009 · Cited by 75
Sensing Lipids with Mincle: Structure and Function
Williams, S. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01662 · Cited by 74
Self-citation
CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis
Lee, J., Boyce, S., Powers, J., Baer, C. E., Sassetti, C. M., & Behar, S. M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008621 · Cited by 70
Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy
Sharma, A., Simonson, T. J., Jondle, C. N., Mishra, B. B., & Sharma, J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix072 · Cited by 61
Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle
van der Peet, P. L., Gunawan, C., Torigoe, S., Yamasaki, S., & Williams, S. J. (2015) · Chemical Communications · doi:10.1039/c5cc00085h · Cited by 56
Self-citation
JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism
Huang, W. C., Wang, B.-O., Hou, Y., Fu, Y., Cui, S., Zhu, J., Zhan, X.-Y., Li, R., Tang, W., Wu, J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158571 · Cited by 55
Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy
Devi, S., Rajakumara, E., & Ahmed, N. (2015) · Scientific Reports · doi:10.1038/srep15049 · Cited by 54
Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands
Braganza, C. D., Teunissen, T., Timmer, M. S. M., & Stocker, B. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01940 · Cited by 54
Innate and Adaptive Immune Response to Fungal Products and Allergens
Williams, P. B., Barnes, C. S., Portnoy, J. M., Barnes, C., Baxi, S., Grimes, C., Horner, W. E., Kennedy, K., Larenas‐Linnemann, D. E., Levetin, E., et al. (2016) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.11.016 · Cited by 56
Lipidated Brartemicin Analogues Are Potent Th1-Stimulating Vaccine Adjuvants
Foster, A. J., Nagata, M., Lu, X., Lynch, A. T., Omahdi, Z., Ishikawa, E., Yamasaki, S., Timmer, M. S. M., & Stocker, B. L. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01468 · Cited by 53
Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling
Walton, E. M., Cronan, M. R., Cambier, C. J., Rossi, A., Marass, M., Foglia, M. D., Brewer, W. J., Poss, K. D., Stainier, D. Y. R., Bertozzi, C. R., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.09.004 · Cited by 52
The laminated layer: Recent advances and insights into Echinococcus biology and evolution
Díaz, Á., Fernández, C., Pittini, Á., Seoane, P. I., Allen, J. E., & Casaravilla, C. (2015) · Experimental Parasitology · doi:10.1016/j.exppara.2015.03.019 · Cited by 53
Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships
Richardson, M. B., Torigoe, S., Yamasaki, S., & Williams, S. J. (2015) · Chemical Communications · doi:10.1039/c5cc04773k · Cited by 48
Self-citation
Targeting Macrophage Polarization for Reinstating Homeostasis following Tissue Damage
Du, Q., Dickinson, A., Nakuleswaran, P., Maghami, S., Alagoda, S., Hook, A. L., & Ghaemmaghami, A. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137278 · Cited by 52
Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia
Lim, J., Lee, J. J., Lee, S.-K., Kim, S., Eum, S., & Eoh, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105800118 · Cited by 49
Artesunate relieves acute kidney injury through inhibiting macrophagic Mincle‐mediated necroptosis and inflammation to tubular epithelial cell
Lei, X., Tan, R., Jia, J., Wu, S., Wen, C., Lin, X., Wang, H., Shi, Z., Li, B., Kang, Y. M., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16833 · Cited by 43
Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from Lactobacillus plantarum and identification of its ability to signal through Mincle
Shah, S., Nagata, M., Yamasaki, S., & Williams, S. J. (2016) · Chemical Communications · doi:10.1039/c6cc05631h · Cited by 45
Self-citation
The cell surface adhesins of Mycobacterium tuberculosis
Vinod, V., Vijayrajratnam, S., Vasudevan, A. K., & Biswas, R. (2019) · Microbiological Research · doi:10.1016/j.micres.2019.126392 · Cited by 45
Radiotherapy as a Backbone for Novel Concepts in Cancer Immunotherapy
Kabiljo, J., Harpain, F., Carotta, S., & Bergmann, M. M. (2019) · Cancers · doi:10.3390/cancers12010079 · Cited by 48
Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
Patin, E. C., Willcocks, S., Orr, S. J., Ward, T. H., Lang, R., & Schaible, U. E. (2016) · Innate Immunity · doi:10.1177/1753425916636671 · Cited by 44
A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shock
Braga, D., Barcella, M., Herpain, A., Aletti, F. M., Kistler, E. B., Pinto, B. B., Bendjelid, K., & Barlassina, C. (2019) · Critical Care · doi:10.1186/s13054-019-2670-8 · Cited by 43
Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat
Wang, Y., Yin, J., Wang, C., Hu, H., Li, X., Xue, M., Liu, J., Cheng, W., Wang, Y., Li, Y., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13890 · Cited by 43
SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury
Lv, L., Wang, C., Li, Z., Cao, J.-Y., Zhong, X., Ye, F., Chen, J., Tang, T., Ni, H.-F., Wu, Q., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04131-7 · Cited by 41
A Fun-Guide to Innate Immune Responses to Fungal Infections
Burgess, T. B., Condliffe, A. M., & Elks, P. M. (2022) · Journal of Fungi · doi:10.3390/jof8080805 · Cited by 44
Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia
Chinthamani, S., Settem, R. P., Honma, K., Kay, J., & Sharma, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173394 · Cited by 37
BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury
He, X., Huang, Y., Liu, Y., Zhang, X., Yue, P., Ma, X., Miao, Z., Long, X., Yang, Y., Wan, X., et al. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5060 · Cited by 39
SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury
Zhang, J., Jiang, J., Wang, B., Wang, Y., Qian, Y., Suo, J., Li, Y., & Peng, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111564 · Cited by 38
Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns
Gartlan, K. H., Krashias, G., Wegmann, F., Hillson, W. R., Scherer, E. M., Greenberg, P. D., Eisenbarth, S. C., Moghaddam, A. E., & Sattentau, Q. J. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.03.025 · Cited by 34
Lipid length and iso-branching of trehalose diesters influences Mincle agonist activity
Khan, A., Kodar, K., Timmer, M. S. M., & Stocker, B. L. (2017) · Tetrahedron · doi:10.1016/j.tet.2017.11.076 · Cited by 33
Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation
Kerscher, B., Dambuza, I. M., Christofi, M., Reid, D. M., Yamasaki, S., Willment, J. A., & Brown, G. D. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.03.007 · Cited by 32
Time-Course Study of the Transcriptome of Peripheral Blood Mononuclear Cells (PBMCs) from Sheep Infected with Fasciola hepatica
Rojas, C. A. Á., Scheerlinck, J. Y., Ansell, B. R. E., Hall, R. S., Gasser, R. B., & Jex, A. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159194 · Cited by 31
Nonulosonic acids contribute to the pathogenicity of the oral bacterium Tannerella forsythia
Bloch, S., Tomek, M. B., Friedrich, V., Messner, P., & Schäffer, C. (2019) · Interface Focus · doi:10.1098/rsfs.2018.0064 · Cited by 28
Medicinal Plant Leaf Extract From Sage and Lemon Verbena Promotes Intestinal Immunity and Barrier Function in Gilthead Seabream (Sparus aurata)
Salomón, R., Reyes‐López, F. E., Tort, L., Firmino, J. P., Sarasquete, C., Ortiz-Delgado, J. B., Quintela, J. C., Pinilla-Rosas, J. M., Vallejos‐Vidal, E., & Gisbert, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670279 · Cited by 27
Immune transcriptome reveals the mincle C-type lectin receptor acts as a partial replacement for TLR4 in lipopolysaccharide-mediated inflammatory response in barramundi ( Lates calcarifer )
Zoccola, E., Kellie, S., & Barnes, A. C. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.01.010 · Cited by 28
Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN
Cramer, J. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00238d · Cited by 26
Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection
Brewer, W. J., Xet-Mull, A. M., Yu, A., Sweeney, M. I., Walton, E. M., & Tobin, D. M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111817 · Cited by 24
Mincle suppresses Toll-like receptor 4 activation
Greco, S. H., Mahmood, S. K., Vahle, A., Ochi, A., Batel, J., Deutsch, M., Barilla, R., Seifert, L., Pachter, H. L., Daley, D., et al. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0515-185r · Cited by 23
Research progress on Mincle as a multifunctional receptor
Huang, X., Yu, Q., Zhang, L., & Jiang, Z. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109467 · Cited by 23
Impact of Asialoglycoprotein Receptor and Mannose Receptor Deficiency on Murine Plasma N-glycome Profiles
Svecla, M., Nour, J., Bladergroen, M. R., Nicolardi, S., Zhang, T., Beretta, G., Wuhrer, M., Norata, G. D., & Falck, D. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100615 · Cited by 23
The liposome of trehalose dimycolate extracted from M. bovis BCG induces antitumor immunity via the activation of dendritic cells and CD8+ T cells
Shiga, M., Miyazaki, J., Tanuma, K., Nagumo, Y., Yoshino, T., Kandori, S., Negoro, H., Kojima, T., Tanaka, R., Okiyama, N., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-02870-2 · Cited by 22
Innate Immune Responses to Fungal Allergens
Portnoy, J. M., Williams, P. B., & Barnes, C. S. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0643-4 · Cited by 23
Macrophage-inducible C-type lectin activates B cells to promote T cell reconstitution in heart allograft recipients
Hasgur, S., Yamamoto, Y., Fan, R., Nicosia, M., Gorbacheva, V., Zwick, D. B., Araki, M., Fairchild, R. L., & Valujskikh, A. (2022) · American Journal of Transplantation · doi:10.1111/ajt.17033 · Cited by 20
Mincle-binding DNA aptamer demonstrates therapeutic potential in a model of inflammatory bowel disease
Stephens, M., Keane, K., Roizes, S., Liao, S., & von der Weid, P. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.05.026 · Cited by 20
Immune sensing of microbial glycolipids and related conjugates by T cells and the pattern recognition receptors MCL and Mincle
Smith, D. G. M., & Williams, S. J. (2015) · Carbohydrate Research · doi:10.1016/j.carres.2015.11.009 · Cited by 20
Self-citation
Tachypleus tridentatus Lectin Enhances Oncolytic Vaccinia Virus Replication to Suppress In Vivo Hepatocellular Carcinoma Growth
Li, G., Cheng, J., Mei, S., Wu, T., & Ye, T. (2018) · Marine Drugs · doi:10.3390/md16060200 · Cited by 19
BAY61‐3606 protects kidney from acute ischemia/reperfusion injury through inhibiting spleen tyrosine kinase and suppressing inflammatory macrophage response
Tan, R., Li, J., Liu, J., Lei, X., Zhong, X., Wang, C., Yan, Y., Ye, L. L., Duan, D. D., Lan, H., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000261rrr · Cited by 20
Understanding Host Immunity and the Gut Microbiota Inspires the New Development of Vaccines and Adjuvants
Yakabe, K., Uchiyama, J., Akiyama, M., & Kim, Y. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020163 · Cited by 18
Inflammasome as an Effective Platform for Fibrosis Therapy
Chen, T., Xiao, F., Li, N., Shan, S., Qi, M., Wang, Z., Zhang, S., Wei, W., & Sun, W. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s304180 · Cited by 17
Cholesteryl 6- O -acyl-α-glucosides from diverse Helicobacter spp. signal through the C-type lectin receptor Mincle
Smith, D. G. M., Ito, E., Yamasaki, S., & Williams, S. J. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob01776k · Cited by 16
Self-citation
Synthetic β-1,2-Mannosyloxymannitol Glycolipid from the Fungus Malassezia pachydermatis Signals through Human Mincle
van der Peet, P. L., Gunawan, C., Watanabe, M., Yamasaki, S., & Williams, S. J. (2019) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.9b00544 · Cited by 16
Self-citation
Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
Fallarini, S., Papi, F., Licciardi, F., Natali, F., Lombardi, G., Maestrelli, F., & Nativi, C. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.2c00383 · Cited by 15
Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle
van der Peet, P. L., Nagata, M., Shah, S., White, J. M., Yamasaki, S., & Williams, S. J. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob01781a · Cited by 15
Self-citation
Lectins of Mycobacterium tuberculosis – rarely studied proteins
Kolbe, K., Veleti, S. K., Reiling, N., & Lindhorst, T. (2019) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.15.1 · Cited by 13
Mechanisms of Immunomodulatory and Membranotropic Activity of Trehalolipid Biosurfactants (a Review)
Kuyukina, M. S., Kochina, O. A., Гейн, С. В., Ившина, И. Б., & Черешнев, В. А. (2020) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683820030072 · Cited by 15
Targeting strategies of liposomal subunit vaccine delivery systems to improve vaccine efficacy
Yu, R., Mai, Y., Zhao, Y., Hou, Y., Liu, Y., & Yang, J. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1547734 · Cited by 14
Macrophage-Inducible C-Type Lectin Signaling Exacerbates Acetaminophen-Induced Liver Injury by Promoting Kupffer Cell Activation in Mice
Zhao, J., Kim, J.-W., Zhou, Z., Qi, J., Tian, W., Lim, C. W., Han, K. M., & Kim, B. (2020) · Molecular Pharmacology · doi:10.1124/molpharm.120.000043 · Cited by 14
Candida albicans steryl 6- O -acyl-α- d -mannosides agonize signalling through Mincle
Nguyen, T. A. T., Hosono, Y., Shimizu, T., Yamasaki, S., & Williams, S. J. (2020) · Chemical Communications · doi:10.1039/d0cc06263d · Cited by 13
Self-citation
Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study
Roh, T., Ju, S., Park, S. Y., Ahn, Y., Chung, J., Nakano, M., Ryu, G., Kim, Y. J., Kim, G., Choi, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56524-3 · Cited by 16
Association between CLEC4E gene polymorphism of mincle and pulmonary tuberculosis infection in a northern Chinese population
Kabuye, D., Chu, Y., Lao, W., Jin, G., & Kang, H. (2019) · Gene · doi:10.1016/j.gene.2019.05.011 · Cited by 13
Cord factor as an invisibility cloak? A hypothesis for asymptomatic TB persistence
Hunter, R. L., Hwang, S., Jagannath, C., & Actor, J. K. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.09.023 · Cited by 13
Ovine C-type lectin receptor hFc-fusion protein library – A novel platform to screen for host-pathogen interactions
Lindenwald, D. L., Monteiro, J. T., Rautenschlein, S., Meens, J., Jung, K., Becker, S. C., & Lepenies, B. (2020) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2020.110047 · Cited by 10
Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas
Sarad, K., Stefańska, M., Kraszewska, I., Szade, K., Sluimer, J. C., Błyszczuk, P., Dulak, J., & Jaźwa, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1249379 · Cited by 10
Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease
Bäckdahl, L., Aoun, M., Norin, U., & Holmdahl, R. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008788 · Cited by 10
β‐Glucan receptors on IL‐4 activated macrophages are required for hookworm larvae recognition and trapping
Bouchery, T., Volpe, B., Doolan, R., Coakley, G., Moyat, M., Bieren, J. E., Wickramasinghe, L. C., Hibbs, M. L., Sotillo, J., Camberis, M., et al. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12536 · Cited by 7
Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines
Tima, H. G., Huygen, K., & Romano, M. (2016) · Expert Review of Vaccines · doi:10.1080/14760584.2016.1187067 · Cited by 8
Design of potent Mincle signalling agonists based on an alkyl β-glucoside template
Smith, D. G. M., Hosono, Y., Nagata, M., Yamasaki, S., & Williams, S. J. (2020) · Chemical Communications · doi:10.1039/d0cc00670j · Cited by 8
Self-citation
Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis
Chen, X., Zhi, L.-J., Chen, J., Li, R., & Long, K. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2024.1456535 · Cited by 10
A c-type lectin HcLec1 with dual function of immunology and mineralization from the freshwater oyster (Hyriopsis cumingii Lea)
Chen, X., Shen, X., Liu, S., Li, W., Wang, H., Li, J., & Bai, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1530732 · Cited by 7
Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate
Hanna, C. C., Maxwell, J. W. C., Ismanto, H. S., Ashhurst, A. S., Artner, L. M., Rudrawar, S., Britton, W. J., Yamasaki, S., & Payne, R. J. (2022) · Chemical Communications · doi:10.1039/d2cc02100e · Cited by 7
DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering
Sandys, O., Stokkers, P. C. F., & Velde, A. A. T. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08523-5 · Cited by 9
Pathogen-Sensing by Mincle: Function and Molecular Aspects
Nagata, M., Omahdi, Z., & Yamasaki, S. (2016) · Springer eBooks · doi:10.1007/978-4-431-56015-9_2 · Cited by 7
Legionella pneumophila modulates macrophage functions through epigenetic reprogramming via the C-type lectin receptor Mincle
Stegmann, F., Diersing, C., & Lepenies, B. (2024) · iScience · doi:10.1016/j.isci.2024.110700 · Cited by 7
Elevated macrophage-inducible C-type lectin expression in the synovial tissue of patients with rheumatoid arthritis
Takata, K., Takano, S., Miyagi, M., Mukai, M., Iwase, D., Aikawa, J., Ohashi, Y., Inoue, G., Takaso, M., & Uchida, K. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2021.111471 · Cited by 6
Probing Isosteric Replacement for Immunoadjuvant Design: Bis-Aryl Triazole Trehalolipids are Mincle Agonists
Foster, M. J., Dangerfield, E. M., Timmer, M. S. M., Stocker, B. L., & Wilkinson, B. L. (2024) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.4c00100 · Cited by 6
Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement
Bhimreddy, M., Rushton, E., Kopke, D. L., & Broadie, K. S. (2021) · Journal of Cell Science · doi:10.1242/jcs.257592 · Cited by 6
From the banal to the bizarre: unravelling immune recognition and response to microbial lipids
Burchill, L., & Williams, S. J. (2021) · Chemical Communications · doi:10.1039/d1cc06003a · Cited by 6
Self-citation
Recognition of Tumor Nidogen-1 by Neutrophil C-Type Lectin Receptors
Sionov, R. V., Lamagna, C., & Granot, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10040908 · Cited by 6
Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages
Moriya, M., Uchida, K., Takano, S., Iwase, D., Inoue, G., Muaki, M., Tazawa, R., Aikawa, J., Sekiguchi, H., & Takaso, M. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2020.103411 · Cited by 6
Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-γ/IL-17 release in bladder cancer treatment
Guallar-Garrido, S., Campo-Pérez, V., Pérez‐Trujillo, M., Cabrera, C., Senserrich, J., Sánchez‐Chardi, A., Rabanal, R. M., Gómez‐Mora, E., Noguera-Ortega, E., Luquin, M., et al. (2022) · OncoImmunology · doi:10.1080/2162402x.2022.2051845 · Cited by 6
Purification of Tannerella forsythia Surface-Layer (S-Layer) Proteins
Chinthamani, S., Settem, R. P., Honma, K., Nakajima, T., & Sharma, A. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0939-2_13 · Cited by 6
Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-gamma/IL-17 release in bladder cancer treatment
Guallar-Garrido, S., Campo-Pérez, V., Pérez‐Trujillo, M., Cabrera, C., Senserrich, J., Sánchez‐Chardi, A., Rabanal Prados, R. M. (. M., Gómez‐Mora, E., Noguera-Ortega, E., Luquin, M., et al. (2022) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 5
Mammalian Pattern Recognition Receptors (PRRs) Involved in Recognition of Fungi
Sey, E. A., Willment, J. A., & Brown, G. D. (2024) · The mycota · doi:10.1007/978-3-031-64853-3_8 · Cited by 4

Authors: Richardson, M. B., & Williams, S. J.
Affiliations: The University of Melbourne (AU)
Corresponding author: Williams, Spencer J.
ORCID: Richardson, Mark B.
Williams, Spencer J.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2014-06-23
Volume: 5
Pages: 288-288
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2014.00288
PMC: PMC4066366
OpenAlex: W2005183346
Cited by: 138
References: 49
Citations by year: 2026: 6 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 16 · 2021: 19 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 12 · 2016: 17 · 2015: 9 · 2014: 1
FWCI: 1.27
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders: Australian Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: Mincle, C-type lectin receptors, pattern recognition receptors, damage-associated molecular patterns, pathogen-associated molecular patterns, trehalose dimycolate, mycobacterial glycolipids, bacterial infection, fungal infection, structure-activity relationship, innate immunity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks