The DOI matches its Crossref record; 104 of the 107 references it cites were found in a registry or an index.
Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders
Open accessAbstract
Macrophages play a paramount role in immunity and inflammation-associated diseases, including infections, cardiovascular diseases, obesity-associated metabolic imbalances, and cancer. Compelling evidence from studies of recent years demonstrates that macrophages are heterogeneous and undergo heterogeneous phenotypic changes in response to microenvironmental stimuli. The M1 killer type response and the M2 repair type response are best known, and are two extreme examples. Among other markers, inducible nitric oxide synthase and type-I arginase (Arg-I), the enzymes that are involved in l-arginine/nitric oxide (NO) metabolism, are associated with the M1 and M2 phenotype, respectively, and therefore widely used as the markers for characterization of the two macrophage phenotypes. There is also a type-II arginase (Arg-II), which is expressed in macrophages and prevalently viewed as having the same function as Arg-I in the cells. In contrast to Arg-I, little information on the role of Arg-II in macrophage inflammatory responses is available. Emerging evidence, however, suggests that differential roles of Arg-I and Arg-II in regulating macrophage functions. In this article, we will review recent developments on the functional roles of the two arginase isoforms in regulation of macrophage inflammatory responses by focusing on their impact on the pathogenesis of cardiovascular diseases and metabolic disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“ARG1 in myeloid cells mainly functions as an enzyme to hydrolyze arginine to produce ornithine as part of the urea cycle, which both promotes tissue repair through generation of polyamines and collagens, and also reduces nitric oxide production from inducible nitric oxide synthase through decreasing intracellular arginine availability (76–78).”
From Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions (2020) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · cited 1×
“, macrophage plasticity, in response to specific signals as a consequence of adaptation to local tissue environmental cues (6, 7).”
BackgroundMacrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 3×
“, macrophage plasticity, in response to specific signals as a consequence of adaptation to local tissue environmental cues (6, 7).”
BackgroundTumor-Associated Macrophages: From Mechanisms to Therapy
Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · cited 1×
“Later on, it was characterized that M1 macrophages are more easily activated by LPS to produce cytotoxic NO via iNOS, whereas M2 macrophages generate little NO but more ornithine from the same substrate l-arginine via arginase (15).”
BackgroundAlternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733
Flagged first, then by citations
3 of the 107 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–291 of 291
Blinova, G. A., Yarygin, K. N., & Kholodenko, I. V. (2024) · Biomedical Chemistry Research and Methods · doi:10.18097/bmcrm00221 · Cited by 5
Boo, H., Park, S. J., Noh, M., Min, H., Jeong, L. S., & Lee, H. (2020) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2019.162 · Cited by 5
“The mRNA expression of M2 macrophage-associated markers, including Arg1 [encoding arginase 1, an M2 macrophage-specific marker (Yang and Ming, 2014)] and Mrc1 [encoding mannose receptor Ctype 1 (also known as CD206), a receptor highly expressed in M2 macrophages (Zhang et al.”
BackgroundAmino Acid Metabolism and Autophagy in Atherosclerotic Cardiovascular Disease
Wu, Y., Avcilar-Kücükgöze, I., Santovito, D., & Atzler, D. (2024) · Biomolecules · doi:10.3390/biom14121557 · Cited by 5
“ARG1 is highly expressed in AAM, and used as an AAM marker, whereas ARG2 may have pro-inflammatory properties and promotes a CAM phenotype [56].”
Ren, Y., Cui, Y., Wang, Z., Luo, Y., Jin, J., Yuan, Y., Li, X., Zhang, Y., Cao, N., Li, X., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08364-8 · Cited by 4
Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemia
Vonderohe, C. E., Stoll, B., Didelija, I. C., Nguyen, T. C., Mohammad, M. A., Jones‐Hall, Y., Cruz, M. A., Marini, J. C., & Burrin, D. G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1400574 · Cited by 4
Jiménez, A., Herrera‐González, A., Organista‐Juárez, D., Estudillo, E., Velasco, I., Guerrero‐Vargas, N. N., Guzmán‐Ruiz, M. A., & Guevara‐Guzmán, R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00319 · Cited by 5
Hansakon, A., & Angkasekwinai, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111995 · Cited by 4
Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac agingPreprint
Potenza, D. M., Cheng, X., Ajalbert, G., Brenna, A., Giraud, M., Frobert, A., Cook, S., Mertz, K. D., Yang, Z., & Ming, X. (2024) · eLife · doi:10.7554/elife.94794 · Cited by 4
“ARG1 is indeed associated with M2- anti-inflammatory macrophages ( Yang and Ming, 2014 ), while ARG2 (but not ARG1) along with NOS2 is enhanced in pro-inflammatory macrophages upon LPS stimulation as shown in the previous study ( Ming et al., 2012 ) and also confirmed in our present study.”
Kadyrov, F. F., Koenig, A. L., Amrute, J. M., Dun, H., Li, W., Weinheimer, C. J., Nigro, J. M., Kovacs, A., Bredemeyer, A. L., Lai, L., et al. (2022) · doi:10.1101/2022.08.04.502542 · Cited by 3
Combination of single-cell and bulk RNA-seq reveals changes in the immune landscape in osteomyelitis
Zhu, Z., Jing, X., Chen, J., Li, S., Tan, J., Zeng, J., & Jin, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1746323 · Cited by 3
Screening and identification of the hub genes in severe acute pancreatitis and sepsis
Yang, S.-J., Luo, Y., Chen, B.-H., & Zhan, L.-H. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1425143 · Cited by 3
Jiang, M., Hu, P.-P., Li, W., Ma, J., Luo, W., Cai, M.-S., Lin, C.-X., Xie, C., Zhang, J., & Ji, J. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01546-25 · Cited by 4
“Regarding arginase, previous studies have shown that elevated arginase activity can lead to decreased NO levels, potentially impairing the ability of macrophages and other immune cells to kill bacteria, which supports our findings (41–43).”
Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury
Gill, N. B., Dowker-Key, P. D., Hubbard, K. N., Voy, B. H., Whelan, J. N., Hedrick, M. S., & Bettaieb, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087345 · Cited by 3
“Although the exact molecular mechanisms are yet to be determined, it has been proposed that G-Rg3 prevents LPS-induced loss of arginase-1 and COX-2 activation [66], which are both key enzymes in the process of M2 differentiation and polarization [67,68].”
BackgroundThe role of CRMP4 in LPS-induced neuroinflammation
Asahina, R., Takahashi, M., Takano, H., Yao, R., Abe, M., Goshima, Y., & Ohshima, T. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149094 · Cited by 3
Pokushalov, E., Kudlay, D. A., Revkov, N., Shcherbakova, A., Johnson, M., & Miller, R. (2025) · Veterinary Sciences · doi:10.3390/vetsci12090919 · Cited by 3
“The ARG1/iNOS ratio—an established read-out of M2 dominance—increased by +0.46 ± 0.18 under the thrice-weekly regimen and +0.29 ± 0.15 under the twice-weekly regimen, versus +0.07 ± 0.12 with placebo (linear trend p 0.001) [24].”
InfluentialAntimicrobial and Innate Immune Tolerance Mechanisms in Biofilms
Sandvik, E. L., Borgogna, T. R., & Stewart, P. S. (2022) · Springer series on biofilms · doi:10.1007/978-3-031-10992-8_2 · Cited by 3
NO Signaling Defects in Hypertension
Fleming, I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00023-5 · Cited by 3
Casella, C., Kiles, F., Urquhart, C., Michaud, D. S., Kirwa, K., & Corlin, L. (2023) · medRxiv · doi:10.1101/2023.09.30.23296386 · Cited by 3
“macrophage pathways linking L-arginine metabolism to inflammation and immunity [198].”
BackgroundCurcumin as a Stabilizer of Macrophage Polarization during Plasmodium Infection
Cordeiro, M. C. C., Tomé, F. D., Arruda, F. D. S., Fonseca, S. G., Nagib, P. R. A., & Celes, M. R. N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102505 · Cited by 3
Yakhshimurodov, U. R., Yamashita, K., Miki, K., Kawamura, T., Saito, S., & Miyagawa, S. (2025) · Biology Methods and Protocols · doi:10.1093/biomethods/bpaf020 · Cited by 2
“This study revealed that the use of Mcsf for the first 3days and the addition of Il4 for the other two days produced CD11b þ / CD206 þ /F4/80 þ and Fizz1 -overexpressing [20] mBMNCs-M2 and CD68 þ [25] and Arg1 -overexpressing [26] rBMNCs-M2 cells from mice and rats BMNCs.”
Beadell, B., & Wong‐Beringer, A. (2025) · mBio · doi:10.1128/mbio.02124-25 · Cited by 2
“…is induced by the antiinflammatory cytokine, IL-10, acting on JAK/STAT pathways to curb hyperinflammation in macrophages, while arginase one production is increased to prioritize arginine as a substrate for downstream production of proline and polyamines to be utilized in tissue repair (45, 46).”
A vicious cycle inducer in gastric pathogenesis: implication of Helicobacter pylori
Rajaei, A., Mahdavi, P., Chimehrad, R., Zakeri, M., Sadeghloo, Z., & Mojarad, E. N. (2026) · Archives of Microbiology · doi:10.1007/s00203-025-04662-z · Cited by 3
“…phagosomes, disrupts the NADPH oxidase system, forms megasomes, and blocks phagosome– lysosome fusion, thereby surviving oxidative and degrada - tive stresses (Choli-Papadopoulou et al. 2011; Salama et al. 2013; Chaturvedi et al. 2004; Butcher et al. 2017; Das et al. 2010 ; Yang and Ming 2014).”
Ravi, S., Martin, L. C., Kumaresan, M., Mani, J. S., Manikandan, B., & Ramar, M. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106951 · Cited by 2
Alveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4
Ponessa, J. J., Jianya, P., Schroeter, M. N., Sawhney, A., Chavan, K., Inclan-Rico, J. M., Espinosa, V., Chen, F., Shubin, N. J., Lung, T. W. F., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117315 · Cited by 2
Liu, J., Li, Z., Chen, X., Zhang, K., Zhu, X., & Yuan, B. (2026) · Regenerative Biomaterials · doi:10.1093/rb/rbag085 · Cited by 2
“…surface marker) participates in injured tissue recognition, extracellular matrix remodeling and anti-inflammatory microenvironment establishment [39]; ARG (M2 intracellular gene) promotes collagen synthesis and tissue repair via arginine metabolism, a core indicator of M2 pro-repair function [40].”
Li, Z.-Z., Wang, X., Ma, L., Wang, H., Xu, J., Zhou, X., Liu, Y., & Guo, J.-R. (2020) · Journal of International Medical Research · doi:10.1177/0300060520947872 · Cited by 38
“Expression of iNOS and Arg-1 are key markers associated with M1 and M2 phenotypes, respectively.(6) For measurement of T helper 1 (Th1) and regulatory T cells (Treg) cells, antimouse CD4 FITC (Abcam) was added and cells were incubated for 30 min at 4 C.”
BackgroundInfluentialRetractedTumor starvation by L-arginine deprivation
Fried, R., Carlton, R. M., & Fried, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824013-7.00005-5 · Cited by 2
C57BL/6 Peritoneal Macrophage Exosomes Improve Antileishmanial Functions of the RAW264.7 Cells
Gandomkar, H., Changaei, M., Hosseini, M. M., Soudi, S., & Hosseini, A. Z. (2024) · Parasite Immunology · doi:10.1111/pim.13069 · Cited by 2
“Considering Arg is primarily expressed in M2 macrophages and participates in the hydrolysis of L-arginine to urea and L-ornithine, it is commonly used as a marker to characterise this phenotype [39].”
An, J., Choi, M., Kim, S., Yoon, H., Jang, A., Lee, S., & Rhim, T. (2025) · Biomaterials Research · doi:10.34133/bmr.0136 · Cited by 2
Marchisio, L., Gaudillat, Q., Muller, J., Zedet, A., Tissot, M., Harakat, D., Sénéjoux, F., Rolin, G., Cardey, B., Girard, C., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117376 · Cited by 2
Shynkevych, V. І., & Кайдашев, І. П. (2019) · Zaporozhye Medical Journal · doi:10.14739/2310-1210.2019.1.155863 · Cited by 2
Majaw, T., & Sharma, R. (2017) · Journal of Biosciences · doi:10.1007/s12038-017-9683-8 · Cited by 2
Arginase: A Prospective Regulator of Oxidative Stress During Microbial Pathogenesis
Bhattacharjee, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8763-0_6 · Cited by 2
Kim, M. K., Jang, S., Namkoong, S., Lee, J. W., Park, Y., Kim, S. H., Lee, S. R., & Sohn, E. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1911.11003 · Cited by 2
“In contrast, M2 macrophages (repair type cells), which are induced by IL-4, IL-13, or glucocorticoid exposure, are involved in inflammation resolution via the secretion of anti-inflammatory cytokines (IL-10 and transforming growth factor-β) and arginase-1, which is involved in ornithine production [8].”
BackgroundMa’arif, B., Muslikh, F. A., Anggraini, W., Taek, M. M., Laswati, H., & Agil, M. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021.v13s4.43855 · Cited by 2
“Continuous M1 polarity state activation of microglia cells can cause prolonged inflammation and induces hippocampal neuron cell death leading to decreased cognitive function [7-9].”
BackgroundGahramanova, M., Ostapchuk, A. M., Molozhava, O. S., Svyatetska, V., Rudyk, M. P., Hurmach, Y., Gorbach, O. I., & Skivka, L. M. (2022) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2020-0098 · Cited by 2
Salivary arginase activity after mechanical-chemical therapy
de Castro, M. V. M., Cortelli, S. C., Rodrigues, E., MORAES, A. D., Costa, F. O., Máximo, P. D. M., & Cortelli, J. R. (2018) · Revista de Odontologia da UNESP · doi:10.1590/1807-2577.09118 · Cited by 2
Heng, C. K. M., Darlyuk‐Saadon, I., Liao, W., Mohanam, M. P., Gan, P. X. L., Gilad, N., Chan, C. C. M. Y., Plaschkes, I., Wong, W. S. F., & Engelberg, D. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108425 · Cited by 1
“%) of AM Φ expressed upregulated levels of Arg1, a marker suggesting M2-like polarization (32), compared to 1.27% of AM Φ in p38 a SFTPC-homo mice not expressing p38 a D176A+F327S (Fig.”
InfluentialKL‐12 Peptide Targets Peri‐Implantitis via Dual Antibacterial and Immunomodulatory Effects
Qin, J., Yang, S., Meng, W., Zhou, Z., Yu, Z., & Zhang, X. (2025) · Oral Diseases · doi:10.1111/odi.15401 · Cited by 2
“Arg-1 is a hallmark of M2 macrophages and plays an essential role in promoting tissue repair (Yang and Ming 2014), as it catalyzes the conversion of L-arginine to ornithine—a molecule known to promote tissue repair (Mills et al. 2000; Morris Jr. 2007).”
Kanayasu‐Toyoda, T., Tanaka, T., Yoshihara, K., Matsumura, G., Hayashi, K., Okura, H., Matsuyama, A., Uchida, E., & Yamaguchi, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-18702-7 · Cited by 1
“Both IDO1 21,22 and ARG1 23,24 which contribute to anti-inflammatory activity, were expressed at high levels in both MIL4-MACs and MACs, as demonstrated by flow cytometry (Fig.”
NK cell hyperactivation drives macrophage repolarization and limits M2 bias in pemphigus vulgaris
Hooda, V., Singh, A., Khandpur, S., Arava, S., Madan, T., & Sharma, A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1774059 · Cited by 1
“…the M2 phenotype in vitro , characterized by increased arginase which may cause suppression of nitric oxide, thereby promoting anti-in fl ammatory responses in addition to tissue repair supported by enhanced CD206 expression, hence, indicating their biological signi fi cance in PV pathogenesis (57).”
Yang, Z., Ming, X., & Potenza, D. M. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1880662 · Cited by 1
“While Arg1 is associated with anti-inflammatory functions of the macrophages (Yang and Ming, 2014), Arg2 has been shown to be pro-inflammatory and plays a role in cardiovascular diseases and aging (Ming et al., 2012; Yepuri et al., 2012; Huang et al., 2021; Zhu et al., 2023; Potenza et al., 2025).”
InfluentialSung, J. J., Digholkar, G., & Pearson, R. M. (2026) · Small · doi:10.1002/smll.74914 · Cited by 2
“Because Arg1 [ 28 ] and Hmgn1 [ 29 ] are associated with macrophage functional polarization and chromatin-mediated transcriptional regulation, respectively, these findings suggest that TCNP engages immune regulatory programs that are mechanistically distinct from glucocorticoid signaling.”
Barone, L. J., Cardoso, N., Mansilla, F. C., Castillo, M., & Capozzo, A. V. (2023) · Virulence · doi:10.1080/21505594.2023.2283899 · Cited by 1
Tang, X., Liu, W., Liang, J., Zhu, X., Ge, X., Fang, D., Ling, L., Yuan, F., Zeng, K., Chen, Q., et al. (2024) · Inflammation · doi:10.1007/s10753-024-02152-w · Cited by 1
“Arg1, a key anti-inflammatory M2 marker in myeloid cells, hydrolyzes arginine to produce ornithine, reducing nitric oxide production and promoting inflammation resolution and tissue repair [14, 15].”
Holland, S. D. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2450-19.2020 · Cited by 1
“Arginase-1 catalyzes the conversion of L-arginine to L-orinthine, which limits the availability of the substrate required to produces nitrous oxide, this ultimately shifts immune cells from a proinflammatory to pro-reparative phenotype (for review, see Yang and Ming, 2014).”
BackgroundRole of Macrophages in Ocular Surface Fibrosis
Corpuz, A. (2022) · Chapman University Digital Commons (Chapman University) · doi:10.36837/chapman.000407 · Cited by 1
Zhao, F., Sharma, D., Sharma, A., Hu, L., Chen, T.-A., Voon, S., Bayless, K. J., Goldman, J., & Walsh, A. J. (2022) · Research Square · doi:10.21203/rs.3.rs-2325499/v1 · Cited by 1
Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac agingPreprint
Potenza, D. M., Cheng, X., Ajalbert, G., Brenna, A., Giraud, M., Frobert, A., Cook, S., Mertz, K. D., Yang, Z., & Ming, X. (2025) · eLife · doi:10.7554/elife.94794.2 · Cited by 1
Cancer and Inflammation : Role of Macrophages and Monocytes
Hedbrant, A. (2015) · Diva portal (Dalarna University Library)
Hedbrant, A. (2015)
Terapia génica anti-inflamatoria en el abordaje de la neurodegeneración dopaminérgica motora
Lockhart, E. F. (2020) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/97168
Leishmaniasis cutánea de evolución crónica
Mauret, M. B. P., Ulloa, F. C., & Bayancela, B. B. (2021) · Piel · doi:10.1016/j.piel.2020.06.004
Adventitia and perivascular adipose tissue—the integral unit in vascular disease
Yang, Z., & Ming, X. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198755777.003.0020
Chronic Chlamyida Infections in Males: Impacts on Testicular Function and Spermatogenesis
Bryan, E. R. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.119158
Mizuno, N., Shiga, S., & Yanagawa, Y. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4163673
Immunometabolic Processes of Macrophages in Disease States
Otieno, F. O. (2023) · Physiology · doi:10.5772/intechopen.109936 · Cited by 1
A High-Throughput Colorimetric Microplate Assay for Determination of Plasma Arginase Activity
Smith, N. J., Maddahfar, M., Gunasegaran, B., McGuire, H. M., & Groth, B. F. D. S. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2942-0_29
Macrophage migration is differentially regulated by distinct ECM componentsPreprint
Stinson, M. W., Laurenson, A. J., & Rotty, J. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.27.538597
“In addition, there are many disease states that manifest alongside chronic inflammation, which may be due in part to dysregulated macrophage polarization.[6-10] A better understanding of how the surrounding microenvironment elicits distinct macrophage functions may give an additional avenue to target”
BackgroundIrisin modulates bone marrow derived macrophage polarization towards M2 profile in high fat fed mice
Magalhães-Santos, J., Simões, R. L., Caldas, C. A., Neto, S. R. M., Barja‐Fidalgo, T. C., Bouskela, E., & Castiglione, R. C. (2023) · Concilium · doi:10.53660/clm-2386-23s13
Влияние триметазидина на метаболизм L-аргинина в лейкоцитах и панкреасе в АС- режиме химиотерапии
Алчуджян, Н. Х., Оганнисян, М. Р., Мовсесян, Н. О., Минасян, Г. Г., & Авагимян, А. А. (2023) · Medical Science of Armenia · doi:10.54503/0514-7484-2023-63.4-49
Yu, H., Jia, X.-Y., Gao, L., Huyan, T., Gou, J., Gong, C.-L., & Gu, L. (2024) · Acta Astronautica · doi:10.1016/j.actaastro.2024.03.056
Metabolic Regulation of Inflammation
Siddiqui, S. I., Chowdhury, S., & Trivedi, A. K. (2024) · Springer eBooks · doi:10.1007/978-981-97-0157-5_8
Durán-Rodríguez, A. T., Almeida, M. P. O., Ferreira, F. B., Lozano-Trujillo, L. A., Gomes, A. D. O., Cariaco, Y., & Silva, N. M. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.03.004
The Design and Manipulation Principles of Immunomodulatory Biomaterials
Gao, R., Zhang, Y., Gao, Y., & Feng, Z. (2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781837675739-00024
Al-Ghunmieen, E. M., Shatanawi, A., Al-Akhras, F. M., Oweidat, K. A., & Alzayadneh, E. M. (2025) · Journal of Asthma and Allergy · doi:10.2147/jaa.s505962
Immunohistochemical characterization of cells of the mononuclear phagocyte system in the mouse
Bertola, L., Valenti, A. G., Cappelleri, A., Canesi, S., Scanziani, E., Recordati, C., & Minoli, L. (2025) · Veterinary Pathology · doi:10.1177/03009858251352581
“9,121,151 Based on morphology, it was possible to discriminate between granulocytes (ie, small round cells with polylobate nuclei) and mononuclear phagocytes (ie, larger cells up to 20 µm in diameter with round to oval nuclei with variable morphology ranging from round to spindle/stellate).”
王, 衍. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15102954
Han, W., Pu, H., Li, S., Liu, Y., Zhao, Y., Xu, M., Chen, C., Wu, Y., Yang, T., Ye, Q., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26607454
Han, W., Pu, H., Li, S., Liu, Y., Zhao, Y., Xu, M., Chen, C., Wu, Y., Yang, T., Ye, Q., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26607451
Balaji, A., Karagiannis, S. N., & McCraw, A. J. (2026) · Allergy · doi:10.1111/all.70249
Noureddine, M., Chang, L., El-Ayache, F., Laghlali, G., Burgess, E. R., Gruneberg, L., Warang, P., Jiang, K., Vandekerckhove, J., Nijhuis, H., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-5760877/v2
Delannoy, C. P. (2017) · theses.fr (ABES) · doi:10.70675/79f16539z1e95z4d83z8d69ze5de14e8bfe1
Chaumonnot, K. (2020) · theses.fr (ABES) · doi:10.70675/af1ab439z66b0z4e99z854dz1e5d91f17f0a
Etude de la transmission intercellulaire du VIH-1 vers les macrophages par fusion cellule-cellule
Mascarau, R. (2022) · theses.fr (ABES) · doi:10.70675/2e3aacaazcd4fz49a5zb350zcd4933447d78
Rodrigues‐Braz, D. (2023) · theses.fr (ABES) · doi:10.70675/b5ea077fz3ec6z4238z8e5ez326aeef1629e
Meena, S. S., Kosgei, B. K., Soko, G. F., Zheng, W., Yu, S., Hu, C., Zhong, Y., Li, B., Wang, L., Mwaiselage, J. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.07.716739
Titus, A. S. C. L. S., Biswas, A. S., Srinivasan, V., Surya, V., Appalaneni, R., Chen, S., Saxena, R., 蔡琪, Truong, L. D., & Mohan, C. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70220
Chavez, B., Sikirzhytski, V., Lim, C., Chatzistamou, I., & Kiaris, H. (2026) · Cancer Biology & Therapy · doi:10.1080/15384047.2026.2688479
4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages
Kang, Y. J. (2026) · Immunology · doi:10.1111/imm.70173
“Although SLC7A2 plays a role in the production of nitric oxide (NO) by inducible NO synthase, increased arginase 1 levels result in the hydrolysis of arginine into ornithine and urea, limiting the production of NO and driving macrophages towards an anti-inflammatory M2 phenotype [31–33].”
Clements, C. M., Mazzei, M., Blimbaum, S., Hay, A. M., Cendali, F. I., Dzieciątkowska, M., Fortis, S. P., Reisz, J. A., Ransegnola, B. P., McNamara, C. A., et al. (2026) · Blood Red Cells & Iron · doi:10.1016/j.brci.2026.100119
Qi, A., Li, Z., Zhou, J., Yuan, H., Zhu, H., & Zhu, B. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.128885
Dai, C., Wang, Z.-H., Guo, M.-H., & Zou, L. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118533
Metadata
- Authors
- Yang, Z., & Ming, X.-F.
- Affiliations
- University of Fribourg (CH)
- Corresponding author
- Yang, Zhihong
- Ming, Xiu-Fen
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014-10-27
- Volume
- 5
- Pages
- 533-533
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4209887
- OpenAlex
- W2018261122
- Cited by
- 290
- References
- 107
- Citations by year
- 2026: 20 · 2025: 31 · 2024: 32 · 2023: 39 · 2022: 30 · 2021: 29 · 2020: 40 · 2019: 23 · 2018: 15 · 2017: 16 · 2016: 5 · 2015: 10
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science Foundation (120435, 310030)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310000-120435/1, 141070, 120435, 310000, 310030)
- Schweizerische Herzstiftung
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- macrophage polarization, M1/M2 macrophage phenotype, inducible nitric oxide synthase, macrophage inflammation, cardiovascular disease, metabolic disorders, obesity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
