Innate Immune Programing by Endotoxin and Its Pathological Consequences

Exploring the full spectrum of macrophage activation

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

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Trained Immunity: A Memory for Innate Host Defense

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Epigenetic Alterations Induced by Bacterial Lipopolysaccharides

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Dysregulation of Hyaluronan Homeostasis During White Matter Injury

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Indoor ozone and particulate matter modify the association between airborne endotoxin and schoolchildren's lung function

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Vitamin D3 alters Toll-like receptor 4 signaling in monocytes of pregnant women at risk for preeclampsia.

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Repeated exposure of male mice to low doses of lipopolysaccharide: Dose and time dependent development of behavioral sensitization and tolerance in an automated light–dark anxiety test

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Assessment of sulfamethoxazole toxicity to marine mussels (Mytilus galloprovincialis): Combine p38-MAPK signaling pathway modulation with histopathological alterations

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Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?

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Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults

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Multi-breed genome-wide association studies across countries for electronically recorded behavior traits in local dual-purpose cows

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Hypomethylation of IL1RN and NFKB1 genes is linked to the dysbalance in IL1β/IL-1Ra axis in female patients with type 2 diabetes mellitus

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Influence of iRoot SP and mineral trioxide aggregate on the activation and polarization of macrophages induced by lipopolysaccharide

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A Novel Lipopolysaccharide Recognition Mechanism Mediated by Internalization in Teleost Macrophages

Lu, X., Ning, Y.-J., Liu, H., Nie, L., & Chen, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02758 · Cited by 22

The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathology: A role for the neuroimmune system and epigenetics

Coleman, L. G., Crews, F. T., & Vetreno, R. P. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.08.001 · Cited by 26

Exogenous heat shock proteins HSPA1A and HSPB1 regulate TNF ‐α, IL ‐1β and IL ‐10 secretion from monocytic cells

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High Mobility Group Box 1 and TLR4 Signaling Pathway in Gnotobiotic Piglets Colonized/Infected with L. amylovorus, L. mucosae, E. coli Nissle 1917 and S. Typhimurium

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Link between mast cells and bacteria: Antimicrobial defense, function and regulation by cytokines

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PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF‐κB pathway

Zhao, J., Yan, S., Zhu, X., Bai, W., Li, J., & Liang, C. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29343 · Cited by 20

Low-Dose LPS Induces Tolerogenic Treg Skewing in Asthma

Ding, F., Liu, B., Niu, C. S., Wang, T., Wang, Y., Geng, G., Tian, D., Dai, J., & Fu, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02150 · Cited by 20

Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits

Lee, J., Geng, S., Li, S., & Li, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.627036 · Cited by 24

Differential antibacterial response of chicken granulosa cells to invasion by Salmonella serovars

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Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models

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Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism

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Photocrosslinked Dextran-Based Hydrogels as Carrier System for the Cells and Cytokines Induce Bone Regeneration in Critical Size Defects in Mice

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Profile of Histone H3 Lysine 4 Trimethylation and the Effect of Lipopolysaccharide/Immune Complex-Activated Macrophages on Endotoxemia

Ruenjaiman, V., Butta, P., Leu, Y., Pongpanich, M., Leelahavanichkul, A., Kueanjinda, P., & Palaga, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02956 · Cited by 17

Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity

Loh, M. K., Stickling, C. P., Schrank, S., Hanshaw, M., Ritger, A. C., Dilosa, N., Finlay, J., Ferrara, N. C., & Rosenkranz, J. A. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06308-8 · Cited by 17

Repeated lipopolysaccharide exposure causes corticosteroid insensitive airway inflammation via activation of phosphoinositide-3-kinase δ pathway

Ueda, K., Nishimoto, Y., Kimura, G., Masuko, T., Barnes, P. J., Ito, K., & Kizawa, Y. (2016) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.07.020 · Cited by 17

The Role of p38 and CK2 Protein Kinases in the Response of RAW 264.7 Macrophages to Lipopolysaccharide

Glushkova, O. V., Parfenyuk, S. B., Novoselova, T. V., Khrenov, M. O., Lunin, S. M., & Novoselova, E. G. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918060123 · Cited by 17

Defective cytokine production early after multiple traumas: Modulation in severe sepsis

Paraschos, M. D., Patrani, M., Pistiki, A. C., Katsenos, C., Τσαγανός, Θ., Netea, M. G., Giamarellos‐Bourboulis, E. J., & Mandragos, K. E. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.021 · Cited by 17

Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation

Palmer, C. D., Romero-Tejeda, M., Sirignano, M., Sharma, S., Allen, T. M., Altfeld, M., & Jost, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501888 · Cited by 16

Chromatin Remodeling in Monocyte and Macrophage Activation

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Redox-sensitive high mobility group box 1 (HMGB1) is a multifunctional regulator of cellular senescence, inflammation, and immunosuppression: Impact on the aging process

Salminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102926 · Cited by 15

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

Kalliara, E., Kardyńska, M., Bagnall, J., Spiller, D. G., Müller, W., Rückerl, D., Biswas, S. K., Śmieja, J., & Paszek, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947213 · Cited by 15

Cross-talk between insulin signalling and LPS responses in mouse macrophages

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Innate immune reconstitution with suppression of HIV-1

Scully, E. P., Lockhart, A. A. K., García-Beltrán, W. F., Palmer, C. D., Musante, C. D., Rosenberg, E. S., Allen, T. M., Chang, J. J., Bosch, R. J., & Altfeld, M. A. (2016) · JCI Insight · doi:10.1172/jci.insight.85433 · Cited by 15

Alteration in the concentrations of Interleukin-7 (IL-7), Interleukin-10 (IL-10) and Granulocyte Colony Stimulating Factor (G-CSF) in alcohol-dependent individuals without liver disease, during detoxification therapy

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Apocynin inhibits Toll-like receptor-4-mediated activation of NF-κB by suppressing the Akt and mTOR pathways

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Phenylbutyrate facilitates homeostasis of non-resolving inflammatory macrophages

Rahtes, A., Pradhan, K., Sarma, M., Xie, D., Lu, C., & Li, L. (2019) · Innate Immunity · doi:10.1177/1753425919879503 · Cited by 16

Toll-like receptor signaling induces a temporal switch towards a resolving lipid profile in monocyte-derived macrophages

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Human αS1-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex

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An Early Neutrophil Recruitment into the Infectious Site Is Critical for Bacterial Lipoprotein Tolerance–Afforded Protection against Microbial Sepsis

Chen, W., Zhao, S., Ita, M., Li, Y., Ji, J., Jiang, Y., Redmond, H. P., Wang, J. H., & Liu, J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801602 · Cited by 14

LPS stimulation during HCV infection induces MMP/TIMP1 imbalance in macrophages

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NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment

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Enhanced autophagy promotes the clearance of Pseudomonas aeruginosa in diabetic rats with wounds

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Prenatal immune stimulation alters the postnatal acute phase and metabolic responses to an endotoxin challenge in weaned beef heifers,

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Programming and memory dynamics of innate leukocytes during tissue homeostasis and inflammation

Lee, C., Geng, S., Zhang, Y., Rahtes, A., & Li, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.6mr0117-027rr · Cited by 13

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

Gan, Y.-Q., Cai, Y.-W., Liang, X., Wang, L., Shi, F., Sun, N., Li, Y., Xu, R., Hu, B., Zha, Q., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1631152 · Cited by 11

Role of TGF-β and p38 MAPK in TSG-6 Expression in Adipose Tissue-Derived Stem Cells In Vitro and In Vivo

Kwon, H. Y., Yoon, Y., Hong, J.-E., Rhee, K., Sohn, J. H., Jung, P. Y., Kim, M. Y., Baik, S. K., Ryu, H., & Eom, Y. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010477 · Cited by 11

NCSTN mutations in hidradenitis suppurativa/acne inversa do not influence cytokine production by peripheral blood mononuclear cells

Xu, H., He, Y., Hui, Y., Xiao, X., Zhang, X., Li, C., & Wang, B. (2016) · British Journal of Dermatology · doi:10.1111/bjd.15076 · Cited by 11

Regulatory Effect of JAK2/STAT3 on the Immune Function of Endotoxin-tolerant Dendritic Cells and its Involvement in Acute Liver Failure

Chen, Y., Hou, C., Yang, N., Yang, Y., Chen, Y., Kong, D., Jiang, Y., Lin, M., Zheng, S., Li, S., et al. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00175 · Cited by 11

The Mechanism of Lipopolysaccharide’s Effect on Secretion of Endometrial Mucins in Female Mice during Pregnancy

Lu, D., Hu, W., Tian, T., Wang, M., Zhou, M., & Wu, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179972 · Cited by 11

An Update on the Study of the Molecular Mechanisms Involved in Autophagy during Bacterial Pathogenesis

Rahman, M. A., Sarker, A., Ayaz, M., Shatabdy, A. R., Haque, N., Jalouli, M., Rahman, M. H., Mou, T. J., Dey, S. K., Apu, E. H., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12081757 · Cited by 11

Dynamic modulation of innate immunity programming and memory

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TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity

Wang, J., Wu, Y., Lin, R., Zhang, Y., & Li, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1297329 · Cited by 10

Signal-Strength and History-Dependent Innate Immune Memory Dynamics in Health and Disease

Geng, S., Pradhan, K., & Li, L. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_485 · Cited by 10

A new animal model for Polygonum multiflorum Thunb-induced liver injury in rats and its potential mechanisms

Fan, X., Wang, J., Xie, L., Dong, Y., Han, G., Hu, D., Liu, Y., Yuan, B., Wang, H., Wu, C., et al. (2015) · Toxicology Research · doi:10.1039/c5tx00054h · Cited by 10

Toll-interacting protein differentially modulates HIF1α and STAT5-mediated genes in fibroblasts

Kowalski, E., Geng, S., Rathes, A., Lu, R., & Li, L. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003382 · Cited by 10

Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention

Scuderi, C., & Golini, L. (2021) · Animals · doi:10.3390/ani11092584 · Cited by 14

Abnormal immune system response in the brain of women with Fibromyalgia after experimental endotoxin challenge

Mueller, C., Jordan, I. A., Jones, C. L., Lawson, P., & Younger, J. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100624 · Cited by 11

Staphylococcus aureus induces tolerance in human monocytes accompanied with expression changes of cell surface markers

Müller, M. M., Baldauf, C., Hornischer, S., Klassert, T. E., Schneegans, A., Behnert, A., Pletz, M. W., Hagel, S., & Slevogt, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1046374 · Cited by 9

Long non-coding RNA SeT and miR-155 regulate the Tnfα gene allelic expression profile

Stathopoulou, C., Kapsetaki, M., Stratigi, K., & Spilianakis, C. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184788 · Cited by 9

Enhanced Neutrophil Immune Homeostasis Due to Deletion of PHLPP

Ran, T., Zhang, Y., Diao, N., Geng, S., Chen, K., Lee, C., & Li, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02127 · Cited by 9

Variability of the innate immune response is globally constrained by transcriptional bursting

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Towards an ecological definition of sepsis: a viewpoint

Bauer, M. W., Shankar‐Hari, M., Thomas-Rüddel, D. O., & Wetzker, R. (2021) · Intensive Care Medicine Experimental · doi:10.1186/s40635-021-00427-2 · Cited by 8

Alleviation of monocyte exhaustion by BCG derivative mycolic acid

Wu, Y., Caldwell, B. A., Wang, J., Zhang, Y., & Li, L. (2024) · iScience · doi:10.1016/j.isci.2024.108978 · Cited by 9

Exploration of new models for primary dysmenorrhea treatment: low-power visible-light-activated photodynamic therapy and oral contraceptives

Wang, Y., Chen, J., Zhang, Z., Ding, X., Gan, J., Guo, Y., Liang, W., Wang, Y., Deng, Y., & Sun, A. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1388045 · Cited by 8

Periodontal Innate Immune Mechanisms Relevant to Atherosclerosis

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Low-dose hydrocortisone prolongs survival in a lethal sepsis model in adrenalectomized rats

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iTRAQ‑based proteomic analysis of endotoxin tolerance induced by lipopolysaccharide

Zhang, Q., Hu, Y., Zhang, J., & Deng, C. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10264 · Cited by 7

Neuroprotective effects of sesamol against LPS-induced spatial learning and memory deficits are mediated via anti-inflammatory and antioxidant activities in the rat brain.

Beheshtimanesh, Z., & Rajaei, Z. (2023) · PubMed Central · doi:10.22038/ajp.2022.21403 · Cited by 7

A PCR-based method for quantifying neutrophils in human nasal secretions

Morris, M. C., Khan, M. N., & Pichichero, M. E. (2017) · Journal of Immunological Methods · doi:10.1016/j.jim.2017.04.010 · Cited by 7

Sensitization of primary cultures from rat dorsal root ganglia with lipopolysaccharide (LPS) requires a robust inflammatory response

Nürnberger, F., Leisengang, S., Ott, D., Murgott, J., Gerstberger, R., Rummel, C. D., & Roth, J. (2021) · Inflammation Research · doi:10.1007/s00011-021-01534-2 · Cited by 6

Engineered Nanomicelles Delivering the Combination of Steroids and Antioxidants Can Mitigate Local and Systemic Inflammation, Including Sepsis

Rana, K., Yadav, P., Chakraborty, R., Jha, S. K., Agrawal, U., & Bajaj, A. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c14159 · Cited by 6

Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species

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Effects of succinates on the inflammatory response: a review

Lazarev, V. V., & Анчутин, П. Е. (2023) · Annals of critical care · doi:10.21320/1818-474x-2023-3-155-165 · Cited by 5

Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients

Turgunov, Y. M., Ogizbayeva, A. V., Akhmaltdinova, L., & Shakeyev, K. T. (2021) · Współczesna Onkologia · doi:10.5114/wo.2021.110051 · Cited by 5

Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles

Camera, G. D., Liu, T., Yang, W., Li, Y., Puntes, V., Gioria, S., Italiani, P., & Boraschi, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314655 · Cited by 5

Parkinson’s disease beyond the brain: implications for treatments

Naeini, S. M., Lopez, M. D., Fraser, P. E., & Tandon, A. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1600782 · Cited by 4

Endogenous humoral determinants of vascular endothelial dysfunction as triggers of acute poisoning complications

Ivnitsky, J. J., Schäfer, T. V., Rejniuk, V. L., & Головко, А. И. (2022) · Journal of Applied Toxicology · doi:10.1002/jat.4312 · Cited by 4

Uncovering Novel Biomarkers of Inflammation as Potential Screening Targets of Disease Risk in Healthcare Shift Workers: A Pilot Study

Atwater, A. Q., & Castañón‐Cervantes, O. (2023) · International Journal of Nursing and Health Care Research · doi:10.29011/2688-9501.101466 · Cited by 4

Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice

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Survival after multiple traumas is associated with improved outcomes from gram-negative sepsis: Clinical and experimental evidence

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