Innate Immune Programing by Endotoxin and Its Pathological Consequences

Exploring the full spectrum of macrophage activation

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Protective and pathogenic functions of macrophage subsets

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Signaling to NF-κB by Toll-like receptors

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Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

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Trained Immunity: A Memory for Innate Host Defense

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Negative regulation of Toll-like receptor-mediated immune responses

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TLR signaling

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Endotoxin tolerance: new mechanisms, molecules and clinical significance

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Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

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Recognition of lipopolysaccharide pattern by TLR4 complexes

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Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

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CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

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The Effects Of Obesity, Smoking, And Drinking On Medical Problems And Costs

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Inflammatory markers in population studies of aging

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Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4

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C-Reactive Protein and the Prediction of Cardiovascular Events Among Those at Intermediate Risk

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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

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Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

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Endotoxin tolerance: A review

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Association of endotoxemia with carotid atherosclerosis and cardiovascular disease

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Epigenetic regulation of the alternatively activated macrophage phenotype

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Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

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Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

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Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation--United States, 2003-2005

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Endotoxemia and gut barrier dysfunction in alcoholic liver disease†

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Obesity among adults in the United States: No statistically significant change since 2003-2004

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IFN-γ Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins

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Systemic low-grade inflammation is related to both circulating and adipose tissue TNFα, leptin and IL-6 levels in obese women

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A comprehensive map of the toll‐like receptor signaling network

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Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

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Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation

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Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation

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Bruton's Tyrosine Kinase Is a Toll/Interleukin-1 Receptor Domain-binding Protein That Participates in Nuclear Factor κB Activation by Toll-like Receptor 4

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Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation

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Potential Role of Endotoxin as a Proinflammatory Mediator of Atherosclerosis

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A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese

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Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross TalkPreprint

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Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

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FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

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Characterization of Interleukin-1 Receptor-associated Kinase in Normal and Endotoxin-tolerant Cells

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Structure, function and regulation of the Toll/IL‐1 receptor adaptor proteins

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Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

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Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients

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Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice.

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Bruton’s Tyrosine Kinase Is Required for TLR2 and TLR4-Induced TNF, but Not IL-6, Production

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Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α–mediated inflammation and insulin resistance in primary human adipocytes

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LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury

Vartanian, K. B., Stevens, S. L., Marsh, B. J., Williams-Karnesky, R. L., Lessov, N. S., & Stenzel‐Poore, M. P. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-140 · Cited by 183

Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotein Cooperatively Activate Macrophages via Nuclear Factor κB and Activator Protein-1

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Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

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Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

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Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide

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Gamma Interferon and Granulocyte/Monocyte Colony-stimulating Factor Prevent Endotoxin Tolerance in Human Monocytes by Promoting Interleukin-1 Receptor-associated Kinase Expression and Its Association to MyD88 and Not by Modulating TLR4 Expression

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B Cell–Specific Loss of Lyn Kinase Leads to Autoimmunity

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Role of Epigenetics in Inflammation-Associated diseases

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Molecular Mechanism Responsible for the Priming of Macrophage Activation

Deng, H., Maitra, U., Morris, M. C., & Li, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.424390 · Cited by 134

CD14-Dependent Internalization of Bacterial Lipopolysaccharide (LPS) Is Strongly Influenced by LPS Aggregation But Not by Cellular Responses to LPS

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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-β-dependent pathways and increases expression of negative regulators of TLR signaling

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IRAK1 Serves as a Novel Regulator Essential for Lipopolysaccharide-induced Interleukin-10 Gene Expression

Huang, Y., Li, T., Sane, D. C., & Li, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410369200 · Cited by 123

Diverse microglial responses after intrahippocampal administration of lipopolysaccharide

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Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway

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Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

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Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

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Extrinsic and intrinsic control of macrophage inflammatory responses

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Resuscitation with Ringer's Ethyl Pyruvate Solution Prolongs Survival and Modulates Plasma Cytokine and Nitrite/Nitrate Concentrations in a Rat Model of Lipopolysaccharide-Induced Shock

Venkataraman, R., Kellum, J. A., Song, M., & Fink, M. P. (2002) · Shock · doi:10.1097/00024382-200212000-00004 · Cited by 104

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

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Endotoxin, TLR4 Signaling and Vascular Inflammation: Potential Therapeutic Targets in Cardiovascular Disease

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Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

Lamagna, C., Scapini, P., Ziffle, J. V., DeFranco, A. L., & Lowell, C. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300617110 · Cited by 98

A common pathway mediated through Toll-like receptors leads to T- and natural killer–cell immunosuppression

Vaknin, I., Blinder, L., Wang, L., Gazit, R., Shapira, E., Genina, O., Pines, M., Pikarsky, E., & Baniyash, M. (2007) · Blood · doi:10.1182/blood-2007-07-100404 · Cited by 98

Hck Tyrosine Kinase Regulates TLR4-Induced TNF and IL-6 Production via AP-1

Smolinska, M., Page, T. H., Urbaniak, A. M., Mutch, B. E., & Horwood, N. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100967 · Cited by 96

GSK3: an in-Toll-erant protein kinase?

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B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

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Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

Hua, Z., Gross, A. J., Lamagna, C., Ramos-Hernández, N., Scapini, P., Ji, M. H., Shao, H., Lowell, C. A., Hou, B., & DeFranco, A. L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300683 · Cited by 93

Lipopolysaccharide-induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro*

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IFN-β Production by TLR4-Stimulated Innate Immune Cells Is Negatively Regulated by GSK3-β

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Phosphatidylinositol-3 Kinase/Akt and GSK-3 Mediated Cytoprotective Effect of Epigallocatechin Gallate on Oxidative Stress-Injured Neuronal-Differentiated N18D3 Cells

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The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn

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Phosphatidylinositol 3-Kinase Activation Attenuates the TLR2-Mediated Macrophage Proinflammatory Cytokine Response to Francisella tularensis Live Vaccine Strain

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Endotoxin levels in sera of elderly individuals

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The Role of JAK-3 in Regulating TLR-Mediated Inflammatory Cytokine Production in Innate Immune Cells

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Akt Regulates Basal and Induced Processing of NF-κB2 (p100) to p52

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Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism

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Computational Approach To Characterize Causative Factors and Molecular Indicators of Chronic Wound Inflammation

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Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells

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Glycogen Synthase Kinase-3 Represses Cyclic AMP Response Element-binding Protein (CREB)-targeted Immediate Early Genes in Quiescent Cells

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Serum Amyloid A3 Binds MD-2 To Activate p38 and NF-κB Pathways in a MyD88-Dependent Manner

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Endotoxinemia and Thrombocytopenia during Neonatal Necrotizing Enterocolitis

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Cellular activation mechanisms in septic shock

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Lipopolysaccharide Improves Cardiomyocyte Survival and Function after Serum Deprivation*

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Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

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Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

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Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress

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The CD14 differentiation antigen mediates the development of endotoxin responsiveness during differentiation of mononuclear phagocytes

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IRAK-M Regulates Chromatin Remodeling in Lung Macrophages during Experimental Sepsis

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Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF-κB Activation in Macrophages

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Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury

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Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14

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TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia

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Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation--United States, 2003-2005.

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Low‐Grade Endotoxemia Contributes to Chronic Inflammation in Hemodialysis Patients: Examination With a Novel Lipopolysaccharide Detection Method

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An Alanine-to-Proline Mutation in the BB-Loop of TLR3 Toll/IL-1R Domain Switches Signalling Adaptor Specificity from TRIF to MyD88

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LPS induces late cardiac functional protection against ischemia independent of cardiac and circulating TNF-α

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PYK2 interacts with MyD88 and regulates MyD88-mediated NF-κB activation in macrophages

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Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis

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Exacerbation of Allergen-Induced Eczema in TLR4- and TRIF-Deficient Mice

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LUNG EFFECTS DURING A GENERALIZED SHWARTZMAN REACTION AND THERAPEUTIC INTERVENTION WITH DEXAMETHASONE OR VITAMIN E

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Pre-treatment with low-dose endotoxin prolongs survival from experimental lethal endotoxic shock: Benefit for lethal peritonitis by Escherichia coli

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Effects of LPS-mediated bystander activation in the innate immune system

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A Novel IRAK1–IKKε Signaling Axis Limits the Activation of TAK1–IKKβ Downstream of TLR3

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Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.

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Cell Death Triggered by Yersinia enterocolitica Identifies Processing of the Proinflammatory Signal Adapter MyD88 as a General Event in the Execution of Apoptosis

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Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes

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Advances in the understanding and treatment of sepsis-induced immunosuppression

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New insights into the multidimensional concept of macrophage ontogeny, activation and function

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Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

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An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

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The endotoxin hypothesis of neurodegeneration

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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of LPS (INM9P.453)

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Dynamic Modulation of Innate Immune Response by Varying Dosages of Lipopolysaccharide (LPS) in Human Monocytic Cells

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Dynamic programming and memory of monocytes by varying signal strengths of innate stimulants

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Dynamic Programming of Innate Immunity in Health and Disease

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Inverse relationship between LPS concentration and monocyte and DC inflammatory response

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