The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Hyaluronan – A Functional and Structural Sweet Spot in the Tissue Microenvironment
Open accessAbstract
Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture, physical properties, and matrix composition result in changes in biomechanical and biochemical cellular signaling. The dynamics of pericellular and extracellular matrices, including matrix protein, proteoglycan, and glycosaminoglycan modification are continually emerging as essential regulatory mechanisms underlying cellular and tissue function. Nevertheless, the impact of matrix organization on inflammation and immunity in particular and the consequent effects on tissue healing and disease outcome are arguably under-studied aspects of adaptive stress responses. Herein, we review how the predominant glycosaminoglycan hyaluronan (HA) contributes to the structure and function of the tissue microenvironment. Specifically, we examine the evidence of HA degradation and the generation of biologically active smaller HA fragments in pathological settings in vivo. We discuss how HA fragments versus nascent HA via alternate receptor-mediated signaling influence inflammatory cell recruitment and differentiation, resident cell activation, as well as tumor growth, survival, and metastasis. Finally, we discuss how HA fragmentation impacts restoration of normal tissue function and pathological outcomes in disease.
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Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
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Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M. L., Calabro, A., Kubalak, S., Klewer, S. E., & McDonald, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10272 · Cited by 901
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
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Hyaluronan in Tissue Injury and Repair
Jiang, D., Liang, J., & Noble, P. W. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123337 · Cited by 835
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2
Scheibner, K. A., Lutz, M. A., Boodoo, S., Fenton, M. J., Powell, J. D., & Horton, M. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.1272 · Cited by 708
Hyaluronan, a Crucial Regulator of Inflammation
Petrey, A. C., & de la Motte, C. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00101 · Cited by 514
Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy
(2014) · Advances in Cancer Research · doi:10.1016/b978-0-12-800092-2.00001-0 · Cited by 204
Fibroblast migration is mediated by CD44-dependent TGFβ activation
Acharya, P. S., Majumdar, S., Jacob, M., Hayden, J., Mrass, P., Weninger, W., Assoian, R. K., & Puré, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.021683 · Cited by 157
Cited by
Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 509
Kim, B. S., Das, S., Jang, J., & Cho, D.-W. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00808 · Cited by 465
Staphylococcus aureus Secreted Toxins and Extracellular Enzymes
Tam, K., & Torres, V. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0039-2018 · Cited by 452
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 367
Amargant, F., Manuel, S. L., Tu, Q., Parkes, W. S., Rivas, F., Zhou, L. T., Rowley, J. E., Villanueva, C. E., Hornick, J. E., Shekhawat, G. S., et al. (2020) · Aging Cell · doi:10.1111/acel.13259 · Cited by 280
Metadata
- Authors
- Monslow, J., Govindaraju, P., & Puré, E.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-05-15
- Volume
- 6
- Pages
- 231-231
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W1537174520
- Cited by
- 180
- References
- 12
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- gold
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