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Cited by 440

The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.

DPP4 in diabetes

Open access
Röhrborn, Diana·2015·Frontiers in Immunology
DOI 10.3389/fimmu.2015.00386
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Abstract

Dipeptidyl-peptidase 4 (DPP4) is a glycoprotein of 110 kDa, which is ubiquitously expressed on the surface of a variety of cells. This exopeptidase selectively cleaves N-terminal dipeptides from a variety of substrates, including cytokines, growth factors, neuropeptides, and the incretin hormones. Expression of DPP4 is substantially dysregulated in a variety of disease states including inflammation, cancer, obesity, and diabetes. Since the incretin hormones, glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GIP), are major regulators of post-prandial insulin secretion, inhibition of DPP4 by the gliptin family of drugs has gained considerable interest for the therapy of type 2 diabetic patients. In this review, we summarize the current knowledge on the DPP4-incretin axis and evaluate most recent findings on DPP4 inhibitors. Furthermore, DPP4 as a type II transmembrane protein is also known to be cleaved from the cell membrane involving different metalloproteases in a cell-type-specific manner. Circulating, soluble DPP4 has been identified as a new adipokine, which exerts both para- and endocrine effects. Recently, a novel receptor for soluble DPP4 has been identified, and data are accumulating that the adipokine-related effects of DPP4 may play an important role in the pathogenesis of cardiovascular disease. Importantly, circulating DPP4 is augmented in obese and type 2 diabetic subjects, and it may represent a molecular link between obesity and vascular dysfunction. A critical evaluation of the impact of circulating DPP4 is presented, and the potential role of DPP4 inhibition at this level is also discussed.

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Metadata

Authors
Röhrborn, D.
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2015
Volume
6
Pages
386-386
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2015.00386
OpenAlex
W1507910610
Cited by
440
References
196
FWCI
22.78
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: DPP4 in diabetes. https://app.cochat.ai/papers/10.3389/fimmu.2015.00386
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Röhrborn, D. (2015). DPP4 in diabetes. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2015.00386

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