The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Emerging Roles for the Immune System in Traumatic Brain Injury
Open accessAbstract
Traumatic brain injury (TBI) affects an ever-growing population of all ages with long-term consequences on health and cognition. Many of the issues that TBI patients face are thought to be mediated by the immune system. Primary brain damage that occurs at the time of injury can be exacerbated and prolonged for months or even years by chronic inflammatory processes, which can ultimately lead to secondary cell death, neurodegeneration, and long-lasting neurological impairment. Researchers have turned to rodent models of TBI in order to understand how inflammatory cells and immunological signaling regulate the post-injury response and recovery mechanisms. In addition, the development of numerous methods to manipulate genes involved in inflammation has recently expanded the possibilities of investigating the immune response in TBI models. As results from these studies accumulate, scientists have started to link cells and signaling pathways to pro- and anti-inflammatory processes that may contribute beneficial or detrimental effects to the injured brain. Moreover, emerging data suggest that targeting aspects of the immune response may offer promising strategies to treat TBI. This review will cover insights gained from studies that approach TBI research from an immunological perspective and will summarize our current understanding of the involvement of specific immune cell types and cytokines in TBI pathogenesis.
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Citations
Cites
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Cited by
Huang, S., Ge, X., Yu, J., Han, Z., Yin, Z., Li, Y., Chen, F., Wang, H., Zhang, J., & Lei, P. (2018) · The FASEB Journal · doi:10.1096/fj.201700673r · Cited by 388
Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.
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Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H., & Zheng, J. C. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101694 · Cited by 202
Parihar, V. K., Maroso, M., Syage, A., Allen, B. D., Angulo, M. C., Soltesz, I., & Limoli, C. L. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.03.009 · Cited by 127
Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
Park, T.-Y., Jeon, J., Lee, N., Kim, J., Song, B., Kim, J.-H., Lee, S.-K., Liu, D., Cha, Y., Kim, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06300-4 · Cited by 128
Metadata
- Authors
- McKee, C. A., & Lukens, J. R.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2016-12-05
- Volume
- 7
- Pages
- 556-556
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2560167144
- Cited by
- 263
- References
- 38
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- gold
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