Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.
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Abstract
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and last out to at least one month post-injury. To investigate a mechanism underlying impaired lymphatic function in TBI, we examined how increased intracranial pressure (ICP) influences the meningeal lymphatics. We demonstrate that increased ICP can contribute to meningeal lymphatic dysfunction. Moreover, we show that pre-existing lymphatic dysfunction before TBI leads to increased neuroinflammation and negative cognitive outcomes. Finally, we report that rejuvenation of meningeal lymphatic drainage function in aged mice can ameliorate TBI-induced gliosis. These findings provide insights into both the causes and consequences of meningeal lymphatic dysfunction in TBI and suggest that therapeutics targeting the meningeal lymphatic system may offer strategies to treat TBI.
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In a mild closed-skull TBI model, meningeal lymphatic drainage is impaired likely due to increases in intracranial pressure, accompanied by lymphatic morphological changes, and lymphangiogenesis was observed up to 2 weeks following TBI without increased lymphatic function.
“In a mild closed-skull TBI model, meningeal lymphatic drainage is impaired likely due to increases in intracranial pressure, accompanied by lymphatic morphological changes”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Bolte et al., 2020
Pre-existing defects in meningeal lymphatics cause worsened neuroinflammation following TBI, and stimulating meningeal lymphatic vessel outgrowth via VEGF-C administration had decreased levels of gliosis.
“pre-existing defects in meningeal lymphatics causes worsened neuroinflammation following TBI”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Bolte et al., 2020
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Increased glymphatic system activity in patients with mild traumatic brain injury
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- Authors
- Bolte, A. C., Dutta, A. B., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Ennerfelt, H. E., Shapiro, D., Nguyen, B. H., Frost, E. L., Lammert, C. R., Kipnis, J., & Lukens, J. R.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Lukens, John R.
- ORCID
- Venue
- Nature Communications
- Published
- 2020-09-10
- Volume
- 11
- Issue
- 1
- Pages
- 4524-4524
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC7483525
- OpenAlex
- W3084255308
- Cited by
- 357
- References
- 83
- Citations by year
- 2026: 52 · 2025: 60 · 2024: 83 · 2023: 67 · 2022: 59 · 2021: 32 · 2020: 4
- FWCI
- 17.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Multiple Sclerosis Society (FG-1707-28590)
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- traumatic brain injury, meningeal lymphatic drainage, lymphatic dysfunction, intracranial pressure, neuroinflammation, cognitive impairment, gliosis, aging, meningeal lymphatic system
- MeSH terms
- Glymphatic System, Dependovirus, Animals, Brain Injuries, Disease Models, Animal, Female, Genetic Vectors, Gliosis, Humans, Male, Meninges, Vascular Endothelial Growth Factor C, Mice
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