The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity
Open accessAbstract
Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell receptor signaling in the development and functioning of adaptive immunity. Growing evidence also suggests multiple roles for BTK in mononuclear cells of the innate immune system, especially in dendritic cells and macrophages. For example, BTK has been shown to function in Toll-like receptor-mediated recognition of infectious agents, cellular maturation and recruitment processes, and Fc receptor signaling. Most recently, BTK was additionally identified as a direct regulator of a key innate inflammatory machinery, the NLRP3 inflammasome. BTK has thus attracted interest not only for gaining a more thorough basic understanding of the human innate immune system but also as a target to therapeutically modulate innate immunity. We here review the latest developments on the role of BTK in mononuclear innate immune cells in mouse versus man, with specific emphasis on the sensing of infectious agents and the induction of inflammation. Therapeutic implications for modulating innate immunity and critical open questions are also discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849
BRUTON, O. C. (1952) · Pediatrics · doi:10.1542/peds.9.6.722 · Cited by 1,492
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis
Di Paolo, J. A., Huang, T., Balazs, M., Barbosa, J., Barck, K. H., Bravo, B. J., Carano, R. A. D., Darrow, J., Davies, D. R., DeForge, L. E., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.481 · Cited by 340
BTKbase: the mutation database for X-linked agammaglobulinemia
Väliaho, J., Smith, C. I. E., & Vihinen, M. (2006) · Human Mutation · doi:10.1002/humu.20410 · Cited by 196
The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation
Volmering, S., Block, H., Boras, M., Lowell, C. A., & Zarbock, A. (2016) · Immunity · doi:10.1016/j.immuni.2015.11.011 · Cited by 98 · cited 1×
“In mice, Btk deficiency also correlated with reduced monocyte/macrophage numbers (33) but favored granulopoiesis (34, 35).”
BackgroundGarstkiewicz, M., Strittmatter, G. E., Grossi, S., Sand, J., Fenini, G., Werner, S., French, L. E., & Beer, H. (2017) · European Journal of Immunology · doi:10.1002/eji.201646665 · Cited by 72 · cited 12×
“Whether BTK also plays a role in the alternative NLRP3 inflammasome dependent on caspase-11 remains to be investigated.”
BackgroundInfluential
Cited by
Inhibition of Bruton tyrosine kinase in patients with severe COVID-19
Roschewski, M., Lionakis, M. S., Sharman, J. P., Roswarski, J., Goy, A., Monticelli, M. A., Roshon, M., Wrzesinski, S. H., Desai, J. V., Zarakas, M. A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abd0110 · Cited by 357
Reich, D. S., Arnold, D. L., Vermersch, P., Bar-Or, A., Fox, R. J., Matta, A., Turner, T., Wallström, E., Zhang, X., Mareš, M., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00237-4 · Cited by 204
Microglia in multiple sclerosis: protectors turn destroyers
Yong, V. W. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.023 · Cited by 185
Bat genomes illuminate adaptations to viral tolerance and disease resistance
Morales, A. E., Dong, Y., Brown, T., Baid, K., Kontopoulos, D. G., Gonzalez, V., Huang, Z., Ahmed, A.-W., Bhuinya, A., Hilgers, L., et al. (2025) · Nature · doi:10.1038/s41586-024-08471-0 · Cited by 78
Bruton’s tyrosine kinase inhibition in multiple sclerosis
Schneider, R., & Oh, J. (2022) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-022-01229-z · Cited by 47
Metadata
- Authors
- Weber, A. N. R., Bittner, Z., Liu, X., Dang, T.-M., Radsak, M. P., & Brunner, C.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2017-11-08
- Volume
- 8
- Pages
- 1454-1454
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2766697888
- Cited by
- 269
- References
- 6
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity. https://app.cochat.ai/papers/10.3389/fimmu.2017.01454
- The paper
- Weber, A. N. R., Bittner, Z., Liu, X., Dang, T.-M., Radsak, M. P., & Brunner, C. (2017). Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2017.01454
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
