The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

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The Src Family Kinases Hck and Fgr Regulate Neutrophil Responses to N -Formyl-Methionyl-Leucyl-Phenylalanine

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Neutrophils and Intravascular Immunity in the Liver during Infection and Sterile Inflammation

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Btk-dependent Rac activation and actin rearrangement following FcεRI aggregation promotes enhanced chemotactic responses of mast cells

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P-Rex1 and Vav1 Cooperate in the Regulation of Formyl-Methionyl-Leucyl-Phenylalanine–Dependent Neutrophil Responses

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The SH3 Domain of Bruton's Tyrosine Kinase Interacts with Vav, Sam68 and EWS

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CCR5 and FPR1 Mediate Neutrophil Recruitment in Endotoxin-Induced Lung Injury

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Protein tyrosine kinases in neutrophil activation and recruitment

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Critical Roles of the WASP N-Terminal Domain and Btk in LPS-Induced Inflammatory Response in Macrophages

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The Role of the Tec Kinase Bruton's Tyrosine Kinase (Btk) in Leukocyte Recruitment

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Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages

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Neutrophils to the ROScue: Mechanisms of NADPH oxidase activation and bacterial resistance

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Role of Bruton’s tyrosine kinase in B cells and malignancies

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Neutrophils as emerging therapeutic targets

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Neutrophils: New insights and open questions

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Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

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Systemic Inflammatory Response Syndrome After Surgery: Mechanisms and Protection

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Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity

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Neutrophil swarming: an essential process of the neutrophil tissue response

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Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns

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Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease

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The role of Bruton's tyrosine kinase in the immune system and disease

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Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver

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The Roles of Neutrophils in Cytokine Storms

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The Role of Myeloid-Derived Cells in the Progression of Liver Disease

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Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO)

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Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies

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Intravital microscopy in historic and contemporary immunology

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Ibrutinib induces multiple functional defects in the neutrophil response against Aspergillus fumigatus

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Tyrosine kinase signaling pathways in neutrophils

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Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

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T-cell expression of Bruton’s tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia

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Skap2 is required for β2 integrin–mediated neutrophil recruitment and functions

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NETosis: an emerging therapeutic target in renal diseases

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Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells

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Bruton’s Tyrosine Kinase Inhibition as an Emerging Therapy in Systemic Autoimmune Disease

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Chronic Recurrent Multifocal Osteomyelitis and Related Diseases—Update on Pathogenesis

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Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus

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Update on the genetics of nonbacterial osteomyelitis in humans

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Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes

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Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive

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Neutrophils—biology and diversity

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The Dual Role of Innate Immune Response in Acetaminophen-Induced Liver Injury

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BTK drives neutrophil activation for sterilizing antifungal immunity

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Neutrophils in animal models of autoimmune disease

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Inhibition of Bruton’s tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy

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The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1

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PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages

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CXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton’s tyrosine kinase

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Crucial functions of gut microbiota on gut–liver repair

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SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

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Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion

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Mechano-Redox Control of Mac-1 De-Adhesion by PDI Promotes Directional Movement Under Flow

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Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking

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PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen‐1 signalling

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Inhibitors of Bruton's tyrosine kinase as emerging therapeutic strategy in autoimmune diseases

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The Role of BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View

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Live Imaging of Innate and Adaptive Immune Responses in the Liver

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Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus

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Imaging innate immunity*

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Targeting Neutrophil β2-Integrins: A Review of Relevant Resources, Tools, and Methods

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Ibrutinib-Induced Neutrophilic Dermatosis

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The Immunomodulatory Mechanisms of BTK Inhibition in CLL and Beyond

Jiang, Q., Peng, Y., Herling, C., & Herling, M. (2024) · Cancers · doi:10.3390/cancers16213574 · Cited by 19 · see citing works

Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia

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Anti-Inflammatory and Immunomodulatory Effects of Intravenous Lidocaine in Surgery: A Narrative Review

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Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro

Carroll, D. J., Cao, Y., Bochner, B. S., & O’Sullivan, J. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.737988 · Cited by 18 · see citing works

Current Perspectives: Evidence to Date on BTK Inhibitors in the Management of Multiple Sclerosis

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The C5a-C5aR1 complement axis is essential for neutrophil recruitment to draining lymph nodes via high endothelial venules in cutaneous leishmaniasis

Prat-Luri, B., Neal, C., Passelli, K., Ganga, E., Amore, J., Firmino-Cruz, L., Petrova, T. V., Müller, A. J., & Tacchini‐Cottier, F. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110777 · Cited by 18 · see citing works

Insights on hematopoietic cell kinase: An oncogenic player in human cancer

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The relation between BTK expression and iron accumulation of myeloid cells in multiple sclerosis

Steinmaurer, A., Riedl, C. J., König, T., Testa, G., Köck, U., Bauer, J., Lassmann, H., Höftberger, R., Berger, T., Wimmer, I., et al. (2024) · Brain Pathology · doi:10.1111/bpa.13240 · Cited by 15 · see citing works

ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation

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Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

de Porto, A. P. N. A., Liu, Z., de Beer, R., Florquin, S., Roelofs, J. J. T. H., de Boer, O. J., den Haan, J. M. M., Hendriks, R. W., Veer, C. V. ′., van der Poll, T., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.723967 · Cited by 16 · see citing works

BTK inhibitor–induced defects in human neutrophil effector activity against Aspergillus fumigatus are restored by TNF-α

Vargas-Blanco, D. A., Hepworth, O. W., Basham, K. J., Simaku, P., Crossen, A. J., Timmer, K. D., Hopke, A. R., Brown, H. E., Vandal, S. R., Jensen, K. N., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.176162 · Cited by 16 · see citing works

Functional implications of neutrophil metabolism during ischemic tissue repair

Piccolo, E. B., Thorp, E. B., & Sumagin, R. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102191 · Cited by 15 · see citing works

Intravital imaging: dynamic insights into liver immunity in health and disease

Wang, Y., Heymann, F., & Peiseler, M. (2024) · Gut · doi:10.1136/gutjnl-2023-331739 · Cited by 16 · see citing works

Effect on neutrophil migration and antimicrobial functions by the Bruton's tyrosine kinase inhibitors tolebrutinib, evobrutinib, and fenebrutinib

Bondt, M. D., Renders, J., de Prado, P. P., Berghmans, N., Pörtner, N., Vanbrabant, L., de Oliveira, V. L. S., Duran, G., Baeten, P., Broux, B., et al. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae160 · Cited by 12 · see citing works

Human PLCG2 haploinsufficiency results in a novel natural killer cell immunodeficiency

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Investigational drugs for immune thrombocytopenia

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A phase I trial assessing the safety, pharmacokinetics, cerebrospinal fluid penetrance, and food effect of BTK inhibitor tolebrutinib in healthy volunteers

Cabanis, M., Nicolas, O., Vitse, O., Jan, C., Brun, P., Soubayrol, P., Smith, W. B., Turner, T. J., & Krupka, E. (2024) · Clinical and Translational Science · doi:10.1111/cts.13693 · Cited by 10 · see citing works

BTK inhibition modulates multiple immune cell populations involved in the pathogenesis of immune mediated nephritis

Chalmers, S. A., Garcia, S. J., Webb, D. S. A., Herlitz, L., Fine, J. S., Klein, E. S., Ramanujam, M., & Putterman, C. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108640 · Cited by 10 · see citing works

Gα13 Mediates Transendothelial Migration of Neutrophils by Promoting Integrin-Dependent Motility without Affecting Directionality

Chang, C. W.-J., Cheng, N., Bai, Y., Skidgel, R. A., & Du, X. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001385 · Cited by 9 · see citing works

In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis

Nagesh, P. T., Cho, Y., Zhuang, Y., Babuta, M., Ortega‐Ribera, M., Joshi, R., Brezáni, V., Patel, A., Datta, A. A., Brezáni, V., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adg1915 · Cited by 8 · see citing works

The Inhibition of Bruton Tyrosine Kinase Alleviates Acute Liver Failure via Downregulation of NLRP3 Inflammasome

Ye, B., Chen, S., Guo, H., Zheng, W., Lou, G., Liang, X., Liu, Y., Zhou, C., & Zheng, M. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2001323 · Cited by 8 · see citing works

Bruton’s tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome

Kröller, S., Wissuwa, B., Dennhardt, S., Krieg, N., Thiemermann, C., Daniel, C., Amann, K., Gunzer, F., & Coldewey, S. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1105181 · Cited by 8 · see citing works

β2-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response

Morikis, V. A., Chen, S. J., Madigan, J., Jo, M. H., Werba, L. C., Ha, T., & Simon, S. I. (2022) · Cells · doi:10.3390/cells11182822 · Cited by 7 · see citing works

Th1 Cells Rolling on Selectins Trigger DAP12-Dependent Signals That Activate Integrin αLβ2

Shao, B., Yago, T., Panicker, S. R., Zhang, N., Liu, Z., & McEver, R. P. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900680 · Cited by 6 · see citing works

Cytoskeletal regulation of dendritic cells: An intricate balance between migration and presentation for tumor therapy

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Identification of a novel Azaspirooxindolinone-based PROTAC for selective BTK degradation and enhanced anticancer activity

Rampeesa, N. K., Gundla, R., Mudasani, G., Tangallapalli, S., Anugu, S. R., Gurská, S., Sanctis, J. B. D., Džubák, P., Hajdúch, M., & Das, V. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108316 · Cited by 5 · see citing works

Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells

Montresor, A., Toffali, L., Fumagalli, L., Constantin, G., Rigo, A., Ferrarini, I., Vinante, F., & Laudanna, C. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001462 · Cited by 5 · see citing works

Association between the AKT1 single nucleotide polymorphism (rs2498786, rs2494752 and rs5811155) and microscopic polyangiitis risk in a Chinese population

Li, L., Rao, J., Lan, J., Zhu, Y., Gong, A., Chu, L., Feng, F., & Xue, C. (2023) · Molecular Genetics and Genomics · doi:10.1007/s00438-023-02012-6 · Cited by 4 · see citing works

Covalent docking-driven virtual screening of extensive small-molecule libraries against Bruton tyrosine kinase for the identification of highly selective and potent novel therapeutic candidates

Sambur, E., Oktay, L., & Durdağı, S. (2024) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2024.108762 · Cited by 4 · see citing works

A Multi-Modal Toolkit for Studying Neutrophils in Cancer and Beyond

Changirwa, D., Schlechte, J., & McDonald, B. (2021) · Cancers · doi:10.3390/cancers13215331 · Cited by 4 · see citing works

Integrin activation by two independently regulated calcium-mediated pathways is required for neutrophil recruitment

Oguama, M., Lindental, P., Clemens, R. A., Lowell, C. A., Soehnlein, O., Roth, J., Bakchoul, T., Cappenberg, A., & Zarbock, A. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02666-w · Cited by 3 · see citing works

Immunomodulating effects of antitumor drugs Bruton tyrosine kinase inhibitors and the possibility of their use in allergic and infectious diseases

Torshina, Y. S., Serebryanaya, N. B., Tv, G., Mikhaleva, M., & Волошин, С. В. (2023) · Medical Immunology (Russia) · doi:10.15789/1563-0625-ieo-2816 · Cited by 1 · see citing works

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

Olbrich, H., Schilf, P., Murthy, S., Gonther, S., Neumann, M., Hammers, C. M., Pruessmann, J. N., & Sadik, C. D. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70321 · Cited by 2 · see citing works

Leukocyte Trafficking and Hemostasis in the Mouse Fetus in vivo: A Practical Guide

Margraf, A., & Sperandio, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.632297

Bruton’s Tyrosine Kinase (BTK) Inhibitors: New Possible Good Candidates against COVID-19

(2020) · British Journal of Cancer Research · doi:10.31488/bjcr.150

Faculty Opinions recommendation of Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.

Mecsas, J. C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727294849.793562336

The Role of Myeloid-Derived Cells in the Progression of Liver Disease

(2020) · Frontiers research topics · doi:10.3389/978-2-88963-313-5

Bruton’s Tyrosine Kinase Deficiency Ameliorates Antimicrobial Host Defense during Peritonitis Induced by Pathogenic Escherichia coli

Liu, Z., Veer, C. V. ′., Hendriks, R. W., Roelofs, J. J. T. H., van der Poll, T., & de Vos, A. F. (2022) · Infection and Immunity · doi:10.1128/iai.00674-21

Inhibitors of Bruton’s tyrosine kinase interfere with neutrophil functions in vitroPreprint

Bondt, M. D., Renders, J., de Prado, P. P., Berghmans, N., Pörtner, N., Vanbrabant, L., Duran, G., Baeten, P., Broux, B., Gouwy, M., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3252455/v1

Clinical advances in immunotherapy for immune-mediated glomerular diseases

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Rilzabrutinib for persistent or chronic immune thrombocytopenia (ITP): a Bruton tyrosine kinase inhibitor that can target multiple pathophysiological pathways

Mjali, A., Audia, S., Miyakawa, Y., & Ghanima, W. (2026) · Expert Review of Hematology · doi:10.1080/17474086.2026.2672113

HVEM-LIGHT signaling promotes antibody-dependent neutrophil FcγR-mediated trogocytosis against herpes simplex virus infection

Gromisch, M. S., Kuraoka, M., Ware, C. F., Almo, S. C., & Herold, B. C. (2026) · Journal of Clinical Investigation · doi:10.1172/jci203771

Differential Effects of Zanubrutinib and Ibrutinib on Neutrophil Antifungal Functions: Insights from Live-Cell Imaging

Marteyn, B., Silvin, A., Thahouly, T., Broussaudier, N., Fauny, J., Barroso, M. V., Fontaine, T., Laribi, K., & Ghez, D. (2026) · Journal of Innate Immunity · doi:10.1159/jin/adhag001

Neutrophil degranulation and extracellular ROS production are inactivated by Yersinia pseudotuberculosis YopE through a SKAP2 independent pathway

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Effect of upadacitinib and ABBV-599 on biomarkers in SLE: results from the phase 2 SLEek study

Gaudreau, M., Catalina, M. D., Sornasse, T., Iyer, A., Filip, I., Contrepois, S., Fann, J., & Merrill, J. T. (2026) · Lupus Science & Medicine · doi:10.1136/lupus-2026-002162

The Role of the Tec Kinase Bruton's Tyrosine Kinase (Btk) in Leukocyte Recruitment

Block, H., & Zarbock, A. (2012) · International Reviews of Immunology · doi:10.3109/08830185.2012.668982 · Cited by 19 · see citing works

PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen‐1 signalling

Herter, J. M., Margraf, A., Volmering, S., Correia, B. E., Bradshaw, J. M., Bisconte, A. R., Hill, R. J., Langrish, C. L., Lowell, C. A., & Zarbock, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14090 · Cited by 25 · see citing works

Bruton's TK regulates myeloid cell recruitment during acute inflammation

Purvis, G. S. D., Aranda-Tavío, H., Channon, K. M., & Greaves, D. R. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15778 · Cited by 23 · see citing works

Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) γ2 and PI3Kγ pathways

Mueller, H., Stadtmann, A., Van Aken, H., Hirsch, E., Wang, D., Ley, K., & Zarbock, A. (2010) · Blood · doi:10.1182/blood-2009-11-254185 · Cited by 164 · see citing works

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation andneutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways

Mueller, H. W., Stadtmann, A., Van Aken, H., Wang, D., Ley, K. F., Alexander, Z., & HIRSCH, E. (2010) · Institutional Research Information System University of Turin (University of Turin)