Plasmacytoid Dendritic Cells Are Largely Dispensable for the Pathogenesis of Experimental Inflammatory Bowel Disease
Open accessAbstract
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by an aberrant immune response to microbial components of the gastrointestinal tract. Plasmacytoid dendritic cells (pDCs) are innate immune cells specialized in the production of type I interferons and were recently implicated in the pathogenesis of autoimmune disorders such as lupus and scleroderma. While pDCs were shown to infiltrate intestinal mucosa of IBD patients and proposed to participate in intestinal inflammation, their net contribution to the disease remains unclear. We addressed this question by targeting the pDC-specific transcription factor TCF4 (E2-2) in experimental IBD caused by deficiency of Wiskott-Aldrich syndrome protein (WASP) or of interleukin-10 (IL-10). Monoallelic Tcf4 deletion, which was previously shown to abrogate experimental lupus, did not affect autoimmunity manifestations or colitis in WASP-deficient animals. Furthermore, conditional biallelic Tcf4 targeting resulted in a near-complete pDC ablation, yet had no effect on the development of colitis in IL-10-deficient mice. Our results suggest that, in contrast to other inflammatory and autoimmune diseases, pDCs do not play a major role in the pathogenesis of intestinal inflammation during IBD.
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DC cluster 2 may have contained plasmacytoid DCs.
“The plasmacytoid DC-specific TFs such as Tcf4 and Runx2 were more active in DC cluster 2 than other DC clusters 22-24 ; thus, DC cluster 2 may have contained plasmacytoid DCs.”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [22]
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CORTES. Thermal & Mechanical Analysis of Tees
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The Immunomodulatory Effects of Arsenic Trioxide in Autoimmunity and Alloreactivity
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Fibroblasts restrain gut inflammation by IGF1-dependent regulation of innate lymphocytes
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- Authors
- Sawai, C. M., Serpas, L., Neto, A. G., Jang, G., Rashidfarrokhi, A., Kolbeck, R., Sanjuan, M. A., Reizis, B., & Sisirak, V.
- Affiliations
- Université de Bordeaux (FR)
- New York University (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Reizis, Boris
- Sisirak, Vanja
- ORCID
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-10-25
- Volume
- 9
- Pages
- 2475-2475
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC6209677
- OpenAlex
- W2896993572
- Cited by
- 20
- References
- 68
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Cancer Research Institute
- National Institutes of Health (AI072571)
- National Institute of General Medical Sciences (T32GM007308)
- National Institute of Allergy and Infectious Diseases (R01AI072571, T32AI100853, R37AI072571)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- plasmacytoid dendritic cells, inflammatory bowel disease, colitis, TCF4, IL-10 deficiency, type I interferon, intestinal inflammation, autoimmunity
- MeSH terms
- Transcription Factor 4, Animals, Colitis, Dendritic Cells, Humans, Immunity, Innate, Lupus Nephritis, Male, Mice, Inbred C57BL, Inflammatory Bowel Diseases, Interleukin-10, Mice, Knockout, Models, Animal, Wiskott-Aldrich Syndrome Protein, Mice
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