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Cited by 137Lymphatic System and DiseasesImmune cells in cancerImmunotherapy and Immune Responses

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Lymph Node Subcapsular Sinus Macrophages as the Frontline of Lymphatic Immune Defense

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Louie, Dante Alexander Patrick, Liao, Shan·2019·Frontiers in Immunology
DOI 10.3389/fimmu.2019.00347PMC PMC6413714
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Abstract

Lymphatic vessels collect and transport lymph and pathogens to the draining lymph node (LN) to generate proper immune protection. A layer of macrophages that strategically line the LN subcapsular sinus (SCS) is directly exposed to the afferent lymph and are denoted as SCS macrophages. These macrophages are the frontline of immune defense that interact with lymph-borne antigens. The importance of these macrophages in limiting the spread of pathogens has been demonstrated in both viral and bacterial infection. In anti-microbial responses, these macrophages can directly or indirectly activate other LN innate immune cells to fight against pathogens, as well as activate T cells or B cells for adaptive immunity. As the first layer of immune cells embracing the tumor-derived antigens, SCS macrophages also actively participate in cancer immune regulation. Recent studies have shown that the LNs' SCS macrophage layer is interrupted in disease models. Despite their importance in fighting the spread of pathogens and in activating anti-tumor immunity, the mechanism and the immunological functional consequences for their disruption are not well-understood. Understanding the mechanism of these macrophages will enhance their capability for therapeutic targeting.

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Metadata

Authors
Louie, D. A. P., & Liao, S.
Affiliations
University of Calgary (CA)
Corresponding author
Liao, Shan
ORCID
Liao, Shan
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2019-02-28
Volume
10
Pages
347-347
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2019.00347
PMC
PMC6413714
OpenAlex
W2912270719
Cited by
137
References
1
Citations by year
2026: 6 · 2025: 27 · 2024: 19 · 2023: 21 · 2022: 21 · 2021: 22 · 2020: 17 · 2019: 3
FWCI
1.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
subcapsular sinus macrophages, lymph nodes, afferent lymph, innate immunity, adaptive immunity, T cell activation, B cell activation, antitumor immunity, viral infection, bacterial infection, therapeutic targeting
MeSH terms
Animals, Disease Susceptibility, Humans, Immunity, Innate, Lymph Nodes, Macrophages, Phenotype, Biomarkers, Host-Pathogen Interactions

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