The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells
Open accessAbstract
The distinction between innate and adaptive immunity is one of the basic tenets of immunology. The co-operation between these two arms of the immune system is a major determinant of the resistance or susceptibility of the host following pathogen invasion. Hence, this interactive co-operation between cells of the innate and adaptive immunity is of significant interest to immunologists. The sub-population of CD4+ T cells with regulatory phenotype (regulatory T cells; Tregs), which constitute a part of the adaptive immune system, have been widely implicated in the regulation of the immune system and maintenance of immune homeostasis. In the last two decades, there has been an explosion in research describing the role of Tregs and their relevance in several immunopathologies ranging from inflammation to cancer. The majority of these studies focus on the role of Tregs on the cells of the adaptive immune system. Recently, there is significant interest in the role of Tregs on cells of the innate immune system. In this review, we examine the literature on the role of Tregs in immunology. Specifically, we focus on the emerging knowledge of Treg interaction with dendritic cells, macrophages and neutrophils which are classical innate immune cells. We highlight this interaction as an important link between innate and adaptive immune systems which also indicate the far-reaching role of Tregs in the regulation of immune responses and maintenance of self-tolerance and immune homeostasis.
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Cites
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“Currently, there is significant interest in the role of regulatory macrophages (Mregs) in inflammation and cancer and the crosstalk between Tregs and Mregs.”
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“Additionally, they demonstrated the significant role of Tregs in maintenance of transplantation tolerance by showing that depletion of Tregs leads to heightened rejection of allogeneic skin grafts (19).”
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Cited by
Treg Heterogeneity, Function, and Homeostasis
Shevyrev, D., & Tereshchenko, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03100 · Cited by 404
The vicious circle of stasis, inflammation, and fibrosis in lymphedema
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Bilal, M., Ashraf, S., & Zhao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931458 · Cited by 58
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Metadata
- Authors
- Okeke, E. B., & Uzonna, J. E.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-04-09
- Volume
- 10
- Pages
- 680-680
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2935887347
- Cited by
- 264
- References
- 175
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- gold
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- Okeke, E. B., & Uzonna, J. E. (2019). The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.00680
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
