The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Treg Heterogeneity, Function, and Homeostasis
Open accessAbstract
T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in providing homeostasis and activation of conventional T-cells is well-known; however, for Tregs, this area is understudied. In the last two decades, evidence has accumulated to confirm the importance of the TCR in Treg homeostasis and antigen-specific immune response regulation. In this review, we describe the current view of Treg subset heterogeneity, homeostasis and function in the context of TCR involvement. Recent studies of the TCR repertoire of Tregs, combined with single-cell gene expression analysis, revealed the importance of TCR specificity in shaping Treg phenotype diversity, their functions and homeostatic maintenance in various tissues. We propose that Tregs, like conventional T-helper cells, act to a great extent in an antigen-specific manner, which is provided by a specific distribution of Tregs in niches.
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Cites
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Cited by
Alvarez-Mon, M. A., Gomez-Lahoz, A. M., Orozco, A., Lahera, G., Sosa-Reina, M. D., Diaz, D., Albillos, A., Quintero, J., Molero, P., Monserrat, J., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.591962 · Cited by 44
CAR-Treg cell therapies and their future potential in treating ocular autoimmune conditions
Abraham, A. R., Maghsoudlou, P., Copland, D. A., Nicholson, L. B., & Dick, A. D. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1184937 · Cited by 20
“Once activated, Tregs have several antigen non-specific mechanisms of action, these include but are not limited to: release of inhibitory cytokines (IL-10, IL-35, TGF-b) (6, 12); consumption of IL-2 inhibiting T-effector cell differentiation and function (13); expression of PD-1 and PD-L1 inhibiting T-cell proliferati…”
BackgroundInfluentialJu, B., Zhu, L., Wang, J., Zheng, J., Hao, Z., Luo, J., Zhang, J., Hu, N., An, Q., Feng, X., et al. (2022) · BMC Immunology · doi:10.1186/s12865-022-00517-0 · Cited by 14
Sedaghat, N., & Etemadifar, M. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103341 · Cited by 13
Metadata
- Authors
- Shevyrev, D., & Tereshchenko, V.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-01-14
- Volume
- 10
- Pages
- 3100-3100
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2999475127
- Cited by
- 404
- References
- 121
- FWCI
- 17.85
- Type
- journal article
- Language
- en
- Open access
- gold
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